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Alzheimer's disease (AD) is a serious neurodegenerative disease consisting of four stages where the illness gets progressively worse. It is of great significance to detect the gene regulatory mechanism as AD progresses and, thus, to help us…

统计方法学 · 统计学 2023-03-14 Shanjun Mao , Xiaodan Fan

Normative modeling has emerged as a pivotal approach for characterizing heterogeneity and individual variance in neurodegenerative diseases, notably Alzheimer's disease(AD). One of the challenges of cortical normative modeling is the…

图像与视频处理 · 电气工程与系统科学 2026-03-13 Jianwei Zhang , Yonggang Shi

Importance: Machine learning (ML) approaches to facial landmark localization carry great clinical potential for quantitative assessment of facial function as they enable high-throughput automated quantification of relevant facial metrics…

Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects cognitive functions such as memory, thinking, and behavior. In this disease, there is a critical phase, mild cognitive impairment, that is really…

信号处理 · 电气工程与系统科学 2024-04-02 Arezoo Borji , Taha-Hossein Hejazi , Abbas Seifi

How will my face look when I get older? Or, for a more challenging question: How will my brain look when I get older? To answer this question one must devise (and learn from data) a multivariate auto-regressive function which given an image…

图像与视频处理 · 电气工程与系统科学 2021-10-01 Tian Xia , Agisilaos Chartsias , Chengjia Wang , Sotirios A. Tsaftaris

Alzheimer's Disease destroys brain cells causing people to lose their memory, mental functions and ability to continue daily activities. It is a severe neurological brain disorder which is not curable, but earlier detection of Alzheimer's…

计算机视觉与模式识别 · 计算机科学 2017-12-21 Jyoti Islam , Yanqing Zhang

Human face aging is irreversible process causing changes in human face characteristics such us hair whitening, muscles drop and wrinkles. Due to the importance of human face aging in biometrics systems, age estimation became an attractive…

计算机视觉与模式识别 · 计算机科学 2016-01-11 Salah Eddine Bekhouche , Abdelkrim Ouafi , Abdelmalik Taleb-Ahmed , Abdenour Hadid , Azeddine Benlamoudi

Alzheimer's disease (AD) is a major neurodegenerative condition that affects millions around the world. As one of the main biomarkers in the AD diagnosis procedure, brain amyloid positivity is typically identified by positron emission…

图像与视频处理 · 电气工程与系统科学 2026-03-10 Yanxi Chen , Mohammad Farazi , Zhangsihao Yang , Yonghui Fan , Nicholas Ashton , Eric M Reiman , Yi Su , Yalin Wang

In this paper, we aim to automatically render aging faces in a personalized way. Basically, a set of age-group specific dictionaries are learned, where the dictionary bases corresponding to the same index yet from different dictionaries…

计算机视觉与模式识别 · 计算机科学 2015-10-23 Xiangbo Shu , Jinhui Tang , Hanjiang Lai , Luoqi Liu , Shuicheng Yan

Progressive diseases worsen over time and are characterised by monotonic change in features that track disease progression. Here we connect ideas from two formerly separate methodologies -- event-based and hidden Markov modelling -- to…

机器学习 · 计算机科学 2021-06-07 Peter A. Wijeratne , Daniel C. Alexander

The human face is a complex trait under strong genetic control, as evidenced by the striking visual similarity between twins. Nevertheless, heritability estimates of facial traits have often been surprisingly low or difficult to replicate.…

应用统计 · 统计学 2017-01-31 Dimosthenis Tsagkrasoulis , Pirro Hysi , Tim Spector , Giovanni Montana

Alzheimer's disease (AD), a degenerative brain condition, can benefit from early prediction to slow its progression. As the disease progresses, patients typically undergo brain atrophy. Current prediction methods for Alzheimers disease…

计算机视觉与模式识别 · 计算机科学 2025-11-27 Xin Honga , Jie Lin , Minghui Wang

In the field of face recognition, a model learns to distinguish millions of face images with fewer dimensional embedding features, and such vast information may not be properly encoded in the conventional model with a single branch. We…

计算机视觉与模式识别 · 计算机科学 2020-05-26 Yonghyun Kim , Wonpyo Park , Myung-Cheol Roh , Jongju Shin

The prediction of subjects with mild cognitive impairment (MCI) who will progress to Alzheimer's disease (AD) is clinically relevant, and may above all have a significant impact on accelerate the development of new treatments. In this…

图像与视频处理 · 电气工程与系统科学 2019-07-16 Kilian Hett , Vinh-Thong Ta , José V. Manjón , Pierrick Coupé

Dementia of Alzheimer's Type (DAT) is a complex disorder influenced by numerous factors, but it is unclear how each factor contributes to disease progression. An in-depth examination of these factors may yield an accurate estimate of…

Objectives: The objectives of this narrative review are to summarize the current state of AI applications in neuroimaging for early Alzheimer's disease (AD) prediction and to highlight the potential of AI techniques in improving early AD…

机器学习 · 计算机科学 2024-06-27 Thorsten Rudroff , Oona Rainio , Riku Klén

Nowadays, due to tremendous improvements in high performance computing, it has become easier to train Neural Networks. We intend to take advantage of this situation and apply this technology in solving real world problems. There was a need…

计算机视觉与模式识别 · 计算机科学 2019-10-15 Gururaj Awate , Sunil Bangare , G Pradeepini , S Patil

Dementia is a syndrome characterised by the decline of different cognitive abilities. Alzheimer's Disease (AD) is the most common dementia affecting cognitive domains such as memory and learning, perceptual-motion or executive function.…

计算机视觉与模式识别 · 计算机科学 2018-10-26 Juan Manuel Fernández Montenegro

Alzheimer's Disease (AD) is a progressive neurodegenerative disease. Amnestic mild cognitive impairment (MCI) is a common first symptom before the conversion to clinical impairment where the individual becomes unable to perform activities…

计算机视觉与模式识别 · 计算机科学 2017-10-16 Donghuan Lu , Karteek Popuri , Weiguang Ding , Rakesh Balachandar , Mirza Faisal Beg

With populations ageing, the number of people with dementia worldwide is expected to triple to 152 million by 2050. Seventy percent of cases are due to Alzheimer's disease (AD) pathology and there is a 10-20 year 'pre-clinical' period…

人工智能 · 计算机科学 2021-04-30 Renjie Li , Xinyi Wang , Katherine Lawler , Saurabh Garg , Quan Bai , Jane Alty