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Prediction performance of a risk scoring system needs to be carefully assessed before its adoption in clinical practice. Clinical preventive care often uses risk scores to screen asymptomatic population. The primary clinical interest is to…

统计方法学 · 统计学 2018-06-22 Yan Yuan , Qian M. Zhou , Bingying Li , Hengrui Cai , Eric J. Chow , Gregory T. Armstrong

Learning causal effects of a binary exposure on time-to-event endpoints can be challenging because survival times may be partially observed due to censoring and systematically biased due to truncation. In this work, we present debiased…

统计方法学 · 统计学 2024-11-15 Eric R. Morenz , Charles J. Wolock , Marco Carone

Inferring treatment effects on a survival time outcome based on data from an observational study is challenging due to the presence of censoring and possible confounding. An additional challenge occurs when a unit's treatment affects the…

统计方法学 · 统计学 2025-08-13 Chanhwa Lee , Donglin Zeng , Michael Emch , John D. Clemens , Michael G. Hudgens

Estimating individualized treatment rules is a central task for personalized medicine. [zhao2012estimating] and [zhang2012robust] proposed outcome weighted learning to estimate individualized treatment rules directly through maximizing the…

统计方法学 · 统计学 2017-10-02 Yifan Cui , Ruoqing Zhu , Michael Kosorok

Although the independent censoring assumption is commonly used in survival analysis, it can be violated when the censoring time is related to the survival time, which often happens in many practical applications. To address this issue, we…

统计方法学 · 统计学 2024-08-28 Huazhen Yu , Lixin Zhang

This paper studies identification and inference in transformation models with endogenous censoring. Many kinds of duration models, such as the accelerated failure time model, proportional hazard model, and mixed proportional hazard model,…

计量经济学 · 经济学 2021-07-05 Shosei Sakaguchi

This paper considers the problem of inferring the causal effect of a variable $Z$ on a dependently censored survival time $T$. We allow for unobserved confounding variables, such that the error term of the regression model for $T$ is…

统计理论 · 数学 2024-10-02 Gilles Crommen , Jad Beyhum , Ingrid Van Keilegom

In prevalent cohort studies with delayed entry, time-to-event outcomes are often subject to left truncation where only subjects that have not experienced the event at study entry are included, leading to selection bias. Existing methods for…

统计方法学 · 统计学 2025-12-25 Yuyao Wang , Andrew Ying , Ronghui Xu

The progression-free survival ratio (PFSr) is a widely used measure in personalized oncology trials. It evaluates the effectiveness of treatment by comparing two consecutive event times - one under standard therapy and one under an…

统计方法学 · 统计学 2025-12-23 Merle Munko , Simon Mack , Marc Ditzhaus , Stefan Fröhling , Dennis Dobler , Dominic Edelmann

Censored data, where the event time is partially observed, are challenging for survival probability estimation. In this paper, we introduce a novel nonparametric fiducial approach to interval-censored data, including right-censored, current…

统计方法学 · 统计学 2021-11-30 Yifan Cui , Jan Hannig , Michael Kosorok

Self-selected samples are frequently obtained due to different levels of survey participation propensity of the survey individuals. When the survey participation is related to the survey topic of interest, propensity score weighting…

应用统计 · 统计学 2014-11-24 Sixia Chen , Jae-Kwang Kim

In a typical two-phase design, a random sample is drawn from the target population in phase 1, during which only a subset of variables is collected. In phase 2, a subsample of the phase-1 cohort is selected, and additional variables are…

统计方法学 · 统计学 2026-03-02 Sky Qiu , Susan Gruber , Pamela A. Shaw , Brian D. Williamson , Mark J. van der Laan

Population attributable fractions aim to quantify the proportion of the cases of an outcome (for example, a disease) that would have been avoided had no individuals in the population been exposed to a given exposure. This quantity thus…

A hybrid censoring scheme is a mixture of Type-I and Type-II censoring schemes. We study the estimation of parameters of weighted exponential distribution based on Type-II hybrid censored data. By applying EM algorithm, maximum likelihood…

统计理论 · 数学 2012-03-02 Akram Kohansal , Saeid Rezakhah

Causal inference is only valid when its underlying assumptions are satisfied, one of the most central being the ignorability or unconfoundedness assumption. However, this hypothesis is often unrealistic in observational studies, as some…

Survival analysis can sometimes involve individuals who will not experience the event of interest, forming what is known as the cured group. Identifying such individuals is not always possible beforehand, as they provide only right-censored…

统计方法学 · 统计学 2024-01-03 Jinqing Li , Jun Ma

In recent years, there has been growing interest in causal machine learning estimators for quantifying subject-specific effects of a binary treatment on time-to-event outcomes. Estimation approaches have been proposed which attenuate the…

统计方法学 · 统计学 2026-03-30 Matthew Pryce , Karla Diaz-Ordaz , Ruth H. Keogh , Stijn Vansteelandt

We consider generalized linear regression analysis with left-censored covariate due to the lower limit of detection. Complete case analysis by eliminating observations with values below limit of detection yields valid estimates for…

统计方法学 · 统计学 2014-12-09 Shengchun Kong , Bin Nan

In this paper, we introduce new parametric and semiparametric regression techniques for a recurrent event process subject to random right censoring. We develop models for the cumula- tive mean function and provide asymptotically normal…

统计理论 · 数学 2015-03-17 Olivier Bouaziz , Ségolen Geffray , Olivier Lopez

With the rapid development of new anti-cancer agents which are cytostatic, new endpoints are needed to better measure treatment efficacy in phase II trials. For this purpose, Von Hoff (1998) proposed the growth modulation index (GMI), i.e.…

统计方法学 · 统计学 2021-11-01 Li Chen , Mark Burkard , Jianrong Wu , Jill M. Kolesar , Chi Wang