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Motivated by simulations of ultrasound-enhanced drug delivery, this work presents the numerical analysis of a mathematical model that captures the influence of ultrasound waves on the diffusivity of the drug. The system under study consists…

数值分析 · 数学 2026-03-10 Femke de Wit , Vanja Nikolić

Heating generated by high-intensity focused ultrasound waves is central to many emerging medical applications, including non-invasive cancer therapy and targeted drug delivery. In this study, we aim to gain a fundamental understanding of…

数值分析 · 数学 2025-10-03 Julio Careaga , Benjamin Dörich , Vanja Nikolić

Accurate simulation of nonlinear acoustic waves is essential for the continued development of a wide range of (high-intensity) focused ultrasound applications. This article explores mixed finite element formulations of classical strongly…

数值分析 · 数学 2022-09-08 Mostafa Meliani , Vanja Nikolić

Optimal control of nonlinear acoustic waves is relevant in many medical ultrasound technologies, ranging from cancer therapy to targeted drug delivery, where it can help guide the precise deposition of acoustic energy. In this work, we…

最优化与控制 · 数学 2025-11-20 Vanja Nikolić , Belkacem Said-Houari

We propose a self-adaptive absorbing technique for quasilinear ultrasound waves in two- and three-dimensional computational domains. As a model for the nonlinear ultrasound propagation in thermoviscous fluids, we employ Westervelt's wave…

数值分析 · 数学 2019-05-01 Markus Muhr , Vanja Nikolić , Barbara Wohlmuth

We consider an undetermined coefficient inverse problem for a nonlinear partial differential equation describing high intensity ultrasound propagation as widely used in medical imaging and therapy. The usual nonlinear term in the standard…

数值分析 · 数学 2022-04-13 Barbara Kaltenbacher , William Rundell

High-Intensity Focused Ultrasound (HIFU) waves are known to induce localized heat to a targeted area during medical treatments. In turn, the rise in temperature influences their speed of propagation. This coupling affects the position of…

偏微分方程分析 · 数学 2022-10-26 Vanja Nikolić , Belkacem Said-Houari

A time-domain numerical code based on the constitutive relations of nonlinear acoustics for simulating ultrasound propagation is presented. To model frequency power law attenuation, such as observed in biological media, multiple relaxation…

Westervelt's equation is a nonlinear wave equation that is widely used to model the propagation of sound waves in a compressible medium, with one important application being ultra-sound in human tissue. Two fundamental aspects of this…

数学物理 · 物理学 2023-06-14 Stephen C. Anco , Almudena P. Marquez , Tamara M. Garrido , Maria L. Gandarias

The Westervelt equation describes the propagation of pressure waves in continuous nonlinear and, eventually, diffusive media. The classical framework of this equation corresponds to fluid dynamics theory. This work seeks to connect this…

经典物理 · 物理学 2025-03-20 Mariano Caruso , Guillermo Rus , Juan Melchor

In this paper we show local (and partially global) in time existence for the Westervelt equation with several versions of nonlinear damping. This enables us to prove well-posedness with spatially varying $L_\infty$-coefficients, which…

偏微分方程分析 · 数学 2015-09-25 Rainer Brunnhuber , Barbara Kaltenbacher , Petronela Radu

The Westervelt equation models the propagation of nonlinear acoustic waves in a regime well-suited for applications such as medical ultrasound imaging. In this work, we prove that the nonlinear parameter, as well as the sound speed, can be…

偏微分方程分析 · 数学 2025-10-06 Mike Wendels

Nonlinear distortion of infrasonic waves through atmospheres up to thermospheric altitudes govern large-range ground-level observations of explosive noise sources, causing large differences between the near and far field. Propagation…

流体动力学 · 物理学 2024-01-29 Liam J. Tope , Jae Wook Kim , Peter Spence

Nonlinear ultrasound imaging leverages harmonic wave generation to enhance contrast and spatial resolution beyond the capabilities of conventional linear techniques. This behavior is commonly modeled by the Westervelt equation, which…

偏微分方程分析 · 数学 2026-05-25 Benjamin Rainer , Barbara Kaltenbacher

Motivated by numerical modeling of ultrasound waves, we investigate robust conforming finite element discretizations of quasilinear and possibly nonlocal equations of Westervelt type. These wave equations involve either a strong dissipation…

数值分析 · 数学 2024-11-05 Vanja Nikolić

The importance of ultrasound is well established in the imaging of human tissue. In order to enhance image quality by exploiting nonlinear effects, recently techniques such as harmonic imaging and nonlinearity parameter tomography have been…

偏微分方程分析 · 数学 2025-02-13 Barbara Kaltenbacher

This paper describes a model for nonlinear acoustic wave propagation through absorbing and weakly dispersive media, and its numerical solution by means of finite differences in time domain method (FDTD). The attenuation is based on multiple…

The goal of this work is to improve focusing of high-intensity ultrasound by modifying the geometry of acoustic lenses through shape optimization. The shape optimization problem is formulated by introducing a tracking-type cost functional…

最优化与控制 · 数学 2017-12-15 Markus Muhr , Vanja Nikolić , Barbara Wohlmuth , Linus Wunderlich

Ultrasound contrast imaging is a specialized imaging technique that applies microbubble contrast agents to traditional medical sonography, providing real-time visualization of blood flow and vessels. Gas-filled microbubbles are injected…

偏微分方程分析 · 数学 2024-12-17 Vanja Nikolić , Teresa Rauscher

Harmonic generation plays a crucial role in contrast-enhanced ultrasound, both for imaging and therapeutic applications. However, accurately capturing these nonlinear effects is computationally very demanding when using traditional…

数值分析 · 数学 2026-02-17 Vanja Nikolić , Teresa Rauscher
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