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When the individual studies assembled for a meta-analysis report means ($\mu_C$, $\mu_T$) for their treatment (T) and control (C) arms, but those data are on different scales or come from different instruments, the customary measure of…

统计方法学 · 统计学 2023-04-18 Elena Kulinskaya , David C. Hoaglin

Methods for random-effects meta-analysis require an estimate of the between-study variance, $\tau^2$. The performance of estimators of $\tau^2$ (measured by bias and coverage) affects their usefulness in assessing heterogeneity of…

统计方法学 · 统计学 2019-03-05 Ilyas Bakbergenuly , David C. Hoaglin , Elena Kulinskaya

Meta-analysis aims to combine effect measures from several studies. For continuous outcomes, the most popular effect measures use simple or standardized differences in sample means. However, a number of applications focus on the absolute…

统计方法学 · 统计学 2023-10-03 Elena Kulinskaya , David C. Hoaglin

Methods for random-effects meta-analysis require an estimate of the between-study variance, $\tau^2$. The performance of estimators of $\tau^2$ (measured by bias and coverage) affects their usefulness in assessing heterogeneity of…

统计方法学 · 统计学 2019-04-04 Ilyas Bakbergenuly , David C. Hoaglin , Elena Kulinskaya

We study estimation and inference using data collected by reinforcement learning (RL) algorithms. These algorithms adaptively experiment by interacting with individual units over multiple stages, updating their strategies based on past…

机器学习 · 统计学 2025-10-06 Vasilis Syrgkanis , Ruohan Zhan

Researchers increasingly use meta-analysis to synthesize the results of several studies in order to estimate a common effect. When the outcome variable is continuous, standard meta-analytic approaches assume that the primary studies report…

Random-effects models are frequently used to synthesise information from different studies in meta-analysis. While likelihood-based inference is attractive both in terms of limiting properties and of implementation, its application in…

应用统计 · 统计学 2018-05-25 Sophia Kyriakou , Ioannis Kosmidis , Nicola Sartori

Random-effects models are frequently used to synthesise information from different studies in meta-analysis. While likelihood-based inference is attractive both in terms of limiting properties and of implementation, its application in…

统计方法学 · 统计学 2018-02-16 Ioannis Kosmidis , Annamaria Guolo , Cristiano Varin

We consider the setting of an aggregate data meta-analysis of a continuous outcome of interest. When the distribution of the outcome is skewed, it is often the case that some primary studies report the sample mean and standard deviation of…

Methods for random-effects meta-analysis require an estimate of the between-study variance, $\tau^2$. The performance of estimators of $\tau^2$ (measured by bias and coverage) affects their usefulness in assessing heterogeneity of…

统计方法学 · 统计学 2019-07-09 Ilyas Bakbergenuly , David C. Hoaglin , Elena Kulinskaya

Random-effects meta-analysis requires an estimate of the between-study variance, $\tau^2$. We study methods of estimation of $\tau^2$ and its confidence interval in meta-analysis of odds ratio, and also the performance of related estimators…

统计方法学 · 统计学 2019-02-20 Ilyas Bakbergenuly , David C. Hoaglin , Elena Kulinskaya

Restricted maximum likelihood (REML) estimation is a widely accepted and frequently used method for fitting linear mixed models, with its principal advantage being that it produces less biased estimates of the variance components. However,…

统计方法学 · 统计学 2025-05-15 Luca Maestrini , Francis K. C. Hui , Alan H. Welsh

This Element offers a practical guide to estimating conditional marginal effects-how treatment effects vary with a moderating variable-using modern statistical methods. Commonly used approaches, such as linear interaction models, often…

统计方法学 · 统计学 2026-05-21 Jiehan Liu , Ziyi Liu , Yiqing Xu

We consider the problem of meta-analyzing two-group studies that report the median of the outcome. Often, these studies are excluded from meta-analysis because there are no well-established statistical methods to pool the difference of…

统计方法学 · 统计学 2022-06-22 Sean McGrath , Hojoon Sohn , Russell Steele , Andrea Benedetti

Linear mixed models (LMMs) are used as an important tool in the data analysis of repeated measures and longitudinal studies. The most common form of LMMs utilize a normal distribution to model the random effects. Such assumptions can often…

统计方法学 · 统计学 2016-02-16 Hien D. Nguyen , Geoffrey J. McLachlan

Since the dawn of response surface methodology, it has been recommended that designs include replicate points, so that pure error estimates of variance can be obtained and used to provide unbiased estimated standard errors of the effects of…

统计方法学 · 统计学 2025-04-24 Steven G Gilmour , Peter Goos , Heiko Grossmann

The restricted mean survival time (RMST) difference offers an interpretable causal contrast to estimate the treatment effect for time-to-event outcomes, yet a wide range of available estimators leaves limited guidance for practice. We…

统计方法学 · 统计学 2026-03-02 Charlotte Voinot , Clément Berenfeld , Imke Mayer , Bernard Sebastien , Julie Josse

The restricted mean survival time (RMST) model has been garnering attention as a way to provide a clinically intuitive measure: the mean survival time. RMST models, which use methods based on pseudo time-to-event values and inverse…

统计方法学 · 统计学 2024-06-11 Keisuke Hanada , Masahiro Kojima

We study efficiency improvements in randomized experiments for estimating a vector of potential outcome means using regression adjustment (RA) when there are more than two treatment levels. We show that linear RA which estimates separate…

计量经济学 · 经济学 2025-01-13 Akanksha Negi , Jeffrey M. Wooldridge

A variety of problems in random-effects meta-analysis arise from the conventional $Q$ statistic, which uses estimated inverse-variance (IV) weights. In previous work on standardized mean difference and log-odds-ratio, we found superior…

统计方法学 · 统计学 2020-10-22 Elena Kulinskaya , David C. Hoaglin , Joseph Newman , Ilyas Bakbergenuly
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