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When beneficial mutations are relatively common, competition between multiple unfixed mutations can reduce the rate of fixation in well-mixed asexual populations. We introduce a one dimensional model with a steady accumulation of beneficial…

种群与进化 · 定量生物学 2013-02-19 Jakub Otwinowski , Stefan Boettcher

Domain growth is a key process in many areas of biology, including embryonic development, the growth of tissue, and limb regeneration. As a result, mechanisms for incorporating it into traditional models for cell movement, interaction, and…

定量方法 · 定量生物学 2019-12-25 Cameron A. Smith , Cécile Mailler , Christian A. Yates

In this work, we consider a diffusive two-species d-dimensional model and study it in great details. Two types of particles, with hard-core, diffuse symmetrically and cross each other. For arbitrary dimensions, we obtain the exact density,…

统计力学 · 物理学 2009-11-07 M. Mobilia , P. -A. Bares

A stochastic model, describing the growth of two competing infections on $\mathbb{R}^d$, is introduced. The growth is driven by outbursts in the infected region, an outburst in the type 1 (2) infected region transmitting the type 1 (2)…

概率论 · 数学 2015-09-24 Maria Deijfen , Olle Häggström , Jonathan Bagley

We consider a two type (red and blue or $R$ and $B$) particle population that evolves on the $d$-dimensional lattice according to some reaction-diffusion process $R+B\to 2R$ and starts with a single red particle and a density $\rho$ of blue…

概率论 · 数学 2009-01-07 A. Gaudilliere , F. R. Nardi

The directed polymerization of actin networks is an essential element of many biological processes, including cell migration. Different theoretical models considering the interplay between the underlying processes of polymerization, capping…

亚细胞过程 · 定量生物学 2013-04-16 Julian Weichsel , Krzysztof Baczynski , Ulrich S. Schwarz

We study an individual-based model in which two spatially-distributed species, characterized by different diffusivities, compete for resources. We consider three different ecological settings. In the first, diffusing faster has a cost in…

种群与进化 · 定量生物学 2016-01-27 Simone Pigolotti , Roberto Benzi

Single molecule and NMR measurements of protein dynamics increasingly uncover the complexity of binding scenarios. Here we describe an extended conformational selection model which embraces a repertoire of selection and adjustment…

生物大分子 · 定量生物学 2010-10-05 Peter Csermely , Robin Palotai , Ruth Nussinov

Identifying the mechanism of intercellular feedback regulation is critical for the basic understanding of tissue growth control in organisms. In this paper, we analyze a tissue growth model consisting of a single lineage of two cell types…

组织与器官 · 定量生物学 2021-09-22 Mao-Xiang Wang , Arthur Lander , Pik-Yin Lai

Monolayer cluster growth in far-from-equilibrium systems is investigated by applying simulation and analytic techniques to minimal hard core particle (exclusion) models. The first model (I), for post-deposition coarsening dynamics, contains…

统计力学 · 物理学 2009-11-10 F. D. A. Aarao Reis , R. B. Stinchcombe

The flow of motor proteins on a filamental track is modelled within the the framework of lattice driven diffusive systems. Motors, considered as hopping particles, perform a highly biased asymmetric exclusion process when bound to the…

统计力学 · 物理学 2007-05-23 M. Ebrahim Fouladvand , Modjtaba Salehi , Mostafa Yadegari

Biofilament-motor protein complexes are ubiquitous in biology and drive the transport of cargo vital for many fundamental cellular processes. As they move, motor proteins exert compressive forces on the filaments to which they are attached,…

生物物理 · 物理学 2024-06-12 Bethany Clarke , Yongyun Hwang , Eric Keaveny

It is increasingly common for models of shallow-layer overland flows to include equations for the evolution of the underlying bed (morphodynamics) and the motion of an associated sedimentary phase. We investigate the linear stability…

流体动力学 · 物理学 2021-07-01 Jake Langham , Mark J. Woodhouse , Andrew J. Hogg , Jeremy C. Phillips

Non-uniform rates of morphological evolution and evolutionary increases in organismal complexity, captured in metaphors like "adaptive zones", "punctuated equilibrium" and "blunderbuss patterns", require more elaborate explanations than a…

种群与进化 · 定量生物学 2020-07-01 Iaroslav Ispolatov , Evgeniia Alekseeva , Michael Doebeli

The functional relevance of regulating proteins is often limited to specific binding sites such as the ends of microtubules or actin-filaments. A localization of proteins on these functional sites is of great importance. We present a…

生物物理 · 物理学 2015-03-04 Emanuel Reithmann , Louis Reese , Erwin Frey

Cell polarization underlies many cellular processes, such as differentiation, migration, and budding. Many living cells, such as budding yeast and fission yeast, use cytoskeletal structures to actively transport proteins to one location on…

生物物理 · 物理学 2022-06-22 Harmen Wierenga , Pieter Rein ten Wolde

We use Wang-Landau and replica exchange techniques to study the effect of an increasing stiffness on the formation of secondary structures in protein-like systems. Two possible models are considered. In both models, a polymer chain is…

软凝聚态物质 · 物理学 2016-09-21 Tatjana Skrbic , Trinh X. Hoang , Achille Giacometti

We consider the statistics of density number of filaments for the propagation of a laser beam subjected to multiple filamentation in a closed area with reflecting boundaries. Dissipation arrests the catastrophic collapse of filaments,…

光学 · 物理学 2012-08-21 A. D. Bulygin

To study the compressional forces exerted by a bundle of living stiff filaments pressing on a surface, akin to the case of an actin bundle in filopodia structures, we have performed particulate Molecular Dynamics simulations of a grafted…

软凝聚态物质 · 物理学 2015-06-17 Sanoop Ramachandran , Jean-Paul Ryckaert

In the growth of bacterial colonies, a great variety of complex patterns are observed in experiments, depending on external conditions and the bacterial species. Typically, existing models employ systems of reaction-diffusion equations or…

生物物理 · 物理学 2019-11-12 Lautaro Vassallo , David Hansmann , Lidia A. Braunstein