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With the covid-19 pandemic still ongoing and an enormous amount of test data available, the lessons learned over the last two years need to be developed to a point where they can provide understanding for tackling new variants and future…

种群与进化 · 定量生物学 2022-06-09 Adam Mielke

This study develops and analyzes an extended Susceptible, Infected, Hospitalized and Recovered (SIHR) model incorporating time dependent control functions to capture preventive measures (e.g., distancing, mask use) and resource limited…

种群与进化 · 定量生物学 2025-10-01 Liban Ismail , Yahyeh Souleiman , Saraless Nadarajah , Abdisalam Hassan

Understanding the dynamics of the spread of diseases within populations is critical for effective public health interventions. We extend the classical SIR model by incorporating additional complexities such as the introduction of a cure and…

种群与进化 · 定量生物学 2025-10-30 Daniel Perkins , Davis Hunter , Drake Brown , Trevor Garrity , Wyatt Pochman

Identifiability is the property in mathematical modelling that determines if model parameters can be uniquely estimated from data. For infectious disease models, failure to ensure identifiability can lead to misleading parameter estimates…

统计方法学 · 统计学 2025-06-10 Fanny Bergström , Martina Favero , Tom Britton

We consider a stochastic Susceptible-Exposed-Infected-Recovered (SEIR) epidemiological model with a contact rate that fluctuates seasonally. Through the use of a nonlinear, stochastic projection, we are able to analytically determine the…

种群与进化 · 定量生物学 2013-09-11 Eric Forgoston , Ira B. Schwartz

The simplest epidemiologic model composed by mutually exclusive compartments SIR (susceptible-infected-susceptible) is presented to describe a reality. From health concerns to situations related with marketing, informatics or even…

物理与社会 · 物理学 2016-11-09 Helena Sofia Rodrigues

The role of epidemiological models is crucial for informing public health officials during a public health emergency, such as the COVID-19 pandemic. However, traditional epidemiological models fail to capture the time-varying effects of…

统计方法学 · 统计学 2022-06-17 Adam Spannaus , Theodore Papamarkou , Samantha Erwin , J. Blair Christian

Mathematical models of infectious diseases exhibit robust dynamics such as stable endemic or a disease-free equilibrium, or convergence of the solutions to periodic epidemic waves. The present work shows that the accuracy of such dynamics…

应用统计 · 统计学 2022-05-04 Hadeel AlQadi , Majid Bani-Yaghoub

The SIR model is a classical model characterizing the spreading of infectious diseases. This model describes the time-dependent quantity changes among Susceptible, Infectious, and Recovered groups. By introducing space-depend effects such…

定量方法 · 定量生物学 2024-09-18 Md Abu Talha , Yongjia Xu , Shan Zhao , Weihua Geng

Deterministic compartmental models are predominantly used in the modeling of infectious diseases, though stochastic models are considered more realistic, yet are complicated to estimate due to missing data. In this paper we present a novel…

统计计算 · 统计学 2022-06-22 Shuying Wang , Stephen G. Walker

Forecasting transmission of infectious diseases, especially for vector-borne diseases, poses unique challenges for researchers. Behaviors of and interactions between viruses, vectors, hosts, and the environment each play a part in…

应用统计 · 统计学 2020-06-02 Stephen A Lauer , Alexandria C Brown , Nicholas G Reich

We consider Susceptible-Infected-Recovered (SIR) models on dense dynamic random graphs, in which the joint dynamics of vertices and edges are co-evolutionary, i.e., they influence each other bidirectionally. In particular, edges appear and…

Reliable estimation of spatio-temporal trends in population-level HIV incidence is becoming an increasingly critical component of HIV prevention policy-making. However, direct measurement is nearly impossible. Current, widely used models…

应用统计 · 统计学 2019-12-04 Timothy M Wolock , Seth R Flaxman , Jeffrey W Eaton

An epidemic model where disease transmission can occur either through global contacts or through local, nearest neighbor interactions is considered. The classical SIR--model describing the global interactions is extended by adding…

种群与进化 · 定量生物学 2022-02-02 Thomas Götz

We present an exact analytical solution to a one-dimensional model of the Susceptible-Infected-Recovered (SIR) epidemic type, with infection rates dependent on nearest-neighbor occupations. We use a quantum mechanical approach, transforming…

统计力学 · 物理学 2015-05-30 H. Thomas Williams , Irina Mazilu , Dan Mazilu

We study the classic Susceptible-Infected-Recovered (SIR) model for the spread of an infectious disease. In this stochastic process, there are two competing mechanism: infection and recovery. Susceptible individuals may contract the disease…

种群与进化 · 定量生物学 2012-05-08 E. Ben-Naim , P. L. Krapivsky

Infectious diseases pose significant human and economic burdens. Accurately forecasting disease incidence can enable public health agencies to respond effectively to existing or emerging diseases. Despite progress in the field, developing…

机器学习 · 计算机科学 2024-09-04 Michael Morris

As the COVID-19 pandemic evolves, reliable prediction plays an important role for policy making. The classical infectious disease model SEIR (susceptible-exposed-infectious-recovered) is a compact yet simplistic temporal model. The…

机器学习 · 计算机科学 2020-10-20 Yunling Zheng , Zhijian Li , Jack Xin , Guofa Zhou

We present a detailed set-based analysis of the well-known SIR and SEIR epidemic models subjected to hard caps on the proportion of infective individuals, and bounds on the allowable intervention strategies, such as social distancing,…

最优化与控制 · 数学 2021-11-17 Willem Esterhuizen , Jean Lévine , Stefan Streif

Retrospective cohorts can be extracted from Electronic Health Records (EHR) to study prevalence, time until disease or event occurrence and cure proportion in real world scenarios. However, EHR are collected for patient care rather than…

统计方法学 · 统计学 2026-02-03 Matilda Pitt , Robert J. B. Goudie