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Synthetic biology is an interdisciplinary field aiming to design biochemical systems with desired behaviors. To this end, molecular controllers have been developed which, when embedded into a pre-existing ambient biochemical network,…

分子网络 · 定量生物学 2019-08-29 Tomislav Plesa , Guy-Bart Stan , Thomas E. Ouldridge , Wooli Bae

This paper is concerned with the deterministic optimal control of Ito stochastic systems with random coefficients. The necessary and sufficient conditions for the unique solvability of the optimal control problem with random coefficients…

最优化与控制 · 数学 2019-03-05 Hongdan Li , Juanjuan Xu , Huanshui Zhang

Finding optimal reaction coordinates and predicting accurate kinetic rates for activated processes are two of the foremost challenges of molecular simulations. We introduce an algorithm that tackles the two problems at once: starting from a…

统计力学 · 物理学 2023-10-30 Line Mouaffac , Karen Palacio-Rodriguez , Fabio Pietrucci

Computational mechanics quantifies structure in a stochastic process via its causal states, leading to the process's minimal, optimal predictor---the $\epsilon$-machine. We extend computational mechanics to communication channels between…

统计力学 · 物理学 2016-01-27 Nix Barnett , James P. Crutchfield

Optimizing paths on networks is crucial for many applications, from subway traffic to Internet communication. As global path optimization that takes account of all path-choices simultaneously is computationally hard, most existing routing…

物理与社会 · 物理学 2013-09-05 Chi Ho Yeung , David Saad , K. Y. Michael Wong

Voltage control plays an important role in the operation of electricity distribution networks, especially with high penetration of distributed energy resources. These resources introduce significant and fast varying uncertainties. In this…

最优化与控制 · 数学 2018-11-07 Pan Li , Baihong Jin , Dai Wang , Baosen Zhang

Scattering from a compound barrier, one composed of a number of distinct non-overlapping sub-barriers, has a number of interesting and subtle mathematical features. If one is scattering classical particles, where the wave aspects of the…

数学物理 · 物理学 2012-02-23 Petarpa Boonserm , Matt Visser

Stochastic Model Predictive Control has proved to be an efficient method to plan trajectories in uncertain environments, e.g., for autonomous vehicles. Chance constraints ensure that the probability of collision is bounded by a predefined…

系统与控制 · 电气工程与系统科学 2021-05-17 Tim Brüdigam , Fulvio di Luzio , Lucia Pallottino , Dirk Wollherr , Marion Leibold

Bertrand et al. introduced a model of parameterised systems, where each agent is represented by a finite state system, and studied the following control problem: for any number of agents, does there exist a controller able to bring all…

形式语言与自动机理论 · 计算机科学 2023-06-22 Thomas Colcombet , Nathanaël Fijalkow , Pierre Ohlmann

We show how the theory of the critical behaviour of $d$-dimensional polymer networks of arbitrary topology can be generalized to the case of networks confined by hyperplanes. This in particular encompasses the case of a single polymer chain…

数学物理 · 物理学 2020-08-26 Bertrand Duplantier , Anthony J Guttmann

A paradigm put forth by E. Schr\"odinger in 1931/32, known as Schr\"odinger bridges, represents a formalism to pose and solve control and estimation problems seeking a perturbation from an initial control schedule (in the case of control),…

最优化与控制 · 数学 2023-07-12 Yongxin Chen , Tryphon T. Georgiou , Michele Pavon

The nucleation of bubbles in first-order phase transitions is traditionally characterised by the critical bubble: defined as the saddle-point solution of the Euclidean action that separates collapsing from expanding field configurations.…

高能物理 - 唯象学 · 物理学 2026-03-05 Tomasz P. Dutka

Resources such as bandwidth and energy are limited in many wireless communications use cases, especially when large numbers of sensors and fusion centers need to exchange information frequently. One opportunity to overcome resource…

系统与控制 · 电气工程与系统科学 2025-10-14 Eva Julia Schmitt , Benjamin Noack

We study the problem of estimating the value function of discrete-time switched systems under arbitrary switching. Unlike the switched LQR problem, where both inputs and mode sequences are optimized, we consider the case where switching is…

最优化与控制 · 数学 2026-02-05 Léa Ninite , Adrien Banse , Guillaume O. Berger , Raphaël M. Jungers

When a chemical reaction is driven by an external field, the transition state that the system must pass through as it changes from reactant to product -for example, an energy barrier- becomes time-dependent. We show that for periodic…

化学物理 · 物理学 2015-05-01 Galen T. Craven , Thomas Bartsch , Rigoberto Hernandez

Stochastic reaction networks is a powerful class of models for the representation a wide variety of population models including biochemistry. The control of such networks has been recently considered due to their important implications for…

最优化与控制 · 数学 2024-09-23 Corentin Briat , Mustafa Khammash

In this paper, we consider the stochastic optimal control problem for the interacting particle system. We obtain the stochastic maximum principle of the optimal control system by introducing a generalized backward stochastic differential…

概率论 · 数学 2025-05-14 Andrey A. Dorogovtsev , Yuecai Han , Kateryna Hlyniana , Yuhang Li

In this note we propose a method based on artificial neural network to study the transition between states governed by stochastic processes. In particular, we aim for numerical schemes for the committor function, the central object of…

机器学习 · 计算机科学 2018-03-01 Yuehaw Khoo , Jianfeng Lu , Lexing Ying

We model the joint distribution of choice probabilities and decision times in binary choice tasks as the solution to a problem of optimal sequential sampling, where the agent is uncertain of the utility of each action and pays a constant…

神经元与认知 · 定量生物学 2015-05-14 Drew Fudenberg , Philipp Strack , Tomasz Strzalecki

Simulations with an adaptive time-dependent bias, such as metadynamics, enable an efficient exploration of the conformational space of a system. However, the dynamic information of the system is altered by the bias. With infrequent…