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A treatment regime is a deterministic function that dictates personalized treatment based on patients' individual prognostic information. There is a fast-growing interest in finding optimal treatment regimes to maximize expected long-term…

统计理论 · 数学 2016-11-25 Runchao Jiang , Wenbin Lu , Rui Song , Marie Davidian

Surgery planning in patients diagnosed with brain tumor is dependent on their survival prognosis. A poor prognosis might demand for a more aggressive treatment and therapy plan, while a favorable prognosis might enable a less risky surgery…

图像与视频处理 · 电气工程与系统科学 2020-09-08 Sobia Yousaf , Syed Muhammad Anwar , Harish RaviPrakash , Ulas Bagci

Head and Neck Squamous Cell Carcinoma (HNSCC) is one of cancer type that is most distressing leading to acute pain, effecting speech and primary survival functions such as swallowing and breathing. The morbidity and mortality of HNSCC…

基因组学 · 定量生物学 2021-05-18 Saurav Mandal , Akshansh Gupta , Waribam Pratibha Chanu

Neoadjuvant chemotherapy (NAC) response prediction for triple negative breast cancer (TNBC) patients is a challenging task clinically as it requires understanding complex histology interactions within the tumor microenvironment (TME).…

计算机视觉与模式识别 · 计算机科学 2024-11-20 Qiang Li , George Teodoro , Yi Jiang , Jun Kong

Accurate survival predicting models are essential for improving targeted cancer therapies and clinical care among cancer patients. In this article, we investigate and develop a method to improve predictions of survival in cancer by…

统计方法学 · 统计学 2025-06-30 Eun Jeong Oh , Seungjun Ahn , Tristan Tham , Min Qian

Ovarian cancer is the most lethal gynecologic malignancy: around 60% of patients are diagnosed at an advanced stage, with an associated 5-year survival rate of about 30%. Early identification of non-responders to neoadjuvant chemotherapy…

Cancer has become one of the most widespread diseases in the world. Specifically, breast cancer is diagnosed more often than any other type of cancer. However, breast cancer patients and their individual tumors are often unique. Identifying…

定量方法 · 定量生物学 2016-12-06 Chenzhe Qian

We calculate measures of hierarchy in gene and tissue networks of breast cancer patients. We find that the likelihood of metastasis in the future is correlated with increased values of network hierarchy for expression networks of…

分子网络 · 定量生物学 2014-01-21 Man Chen , Michael W. Deem

To facilitate early detection of breast cancer, there is a need to develop short-term risk prediction schemes that can prescribe personalized/individualized screening mammography regimens for women. In this study, we propose a new deep…

图像与视频处理 · 电气工程与系统科学 2024-12-05 Hong Hui Yeoh , Fredrik Strand , Raphaël Phan , Kartini Rahmat , Maxine Tan

In this paper, we describe a dataset relating to cellular and physical conditions of patients who are operated upon to remove colorectal tumours. This data provides a unique insight into immunological status at the point of tumour removal,…

机器学习 · 计算机科学 2016-11-17 Chris Roadknight , Uwe Aickelin , Guoping Qiu , John Scholefield , Lindy Durrant

Adherence can be defined as "the extent to which patients take their medications as prescribed by their healthcare providers"[Osterberg and Blaschke, 2005]. World Health Organization's reports point out that, in developed countries, only…

机器学习 · 计算机科学 2018-11-30 Thomas Janssoone , Clémence Bic , Dorra Kanoun , Pierre Hornus , Pierre Rinder

First-line antiproliferatives for non-small cell lung cancer (NSCLC) have a relatively high failure rate due to high intrinsic resistance rates and acquired resistance rates to therapy. 57% patients are diagnosed in late-stage disease due…

细胞行为 · 定量生物学 2024-01-17 Benjamin Schneider , Sébastien Benzekry , Jonathan Mochel

The ability to accurately estimate risk of developing breast cancer would be invaluable for clinical decision-making. One promising new approach is to integrate image-based risk models based on deep neural networks. However, one must take…

图像与视频处理 · 电气工程与系统科学 2020-09-17 Yue Liu , Hossein Azizpour , Fredrik Strand , Kevin Smith

In order to investigate the breast cancer prediction problem on the aging population with the grades of DCIS, we conduct a tree augmented naive Bayesian network experiment trained and tested on a large clinical dataset including consecutive…

机器学习 · 统计学 2015-06-19 Ping Ren

Deep learning for regression tasks on medical imaging data has shown promising results. However, compared to other approaches, their power is strongly linked to the dataset size. In this study, we evaluate 3D-convolutional neural networks…

计算机视觉与模式识别 · 计算机科学 2018-11-13 Yannick Suter , Alain Jungo , Michael Rebsamen , Urspeter Knecht , Evelyn Herrmann , Roland Wiest , Mauricio Reyes

Prognostication for lung cancer, a leading cause of mortality, remains a complex task, as it needs to quantify the associations of risk factors and health events spanning a patient's entire life. One challenge is that an individual's…

机器学习 · 统计学 2025-08-28 Stephen Salerno , Yi Li

Brain tumor is a life-threatening problem and hampers the normal functioning of the human body. The average five-year relative survival rate for malignant brain tumors is 35.6 percent. For proper diagnosis and efficient treatment planning,…

图像与视频处理 · 电气工程与系统科学 2024-07-16 Vidhyapriya Ranganathan , Celshiya Udaiyar , Jaisree Jayanth , Meghaa P , Srija B , Uthra S

Predicting the likelihood of survival is of paramount importance for individuals diagnosed with cancer as it provides invaluable information regarding prognosis at an early stage. This knowledge enables the formulation of effective…

计算机视觉与模式识别 · 计算机科学 2024-03-19 Numan Saeed , Muhammad Ridzuan , Fadillah Adamsyah Maani , Hussain Alasmawi , Karthik Nandakumar , Mohammad Yaqub

Cancer, a leading cause of death globally, occurs due to genomic changes and manifests heterogeneously across patients. To advance research on personalized treatment strategies, the effectiveness of various drugs on cells derived from…

机器学习 · 计算机科学 2024-05-08 Kumar Shubham , Aishwarya Jayagopal , Syed Mohammed Danish , Prathosh AP , Vaibhav Rajan

Determining the extent to which a patient is benefiting from cancer therapy is challenging. Criteria for quantifying the extent of "tumor response" observed within a few cycles of treatment have been established for various types of solid…

统计方法学 · 统计学 2020-09-18 Jie Zhou , Xun Jiang , H. Amy Xia , Peng Wei , Brian P. Hobbs