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Mendelian randomization uses genetic variants to make causal inferences about a modifiable exposure. Subject to a genetic variant satisfying the instrumental variable assumptions, an association between the variant and outcome implies a…

统计方法学 · 统计学 2018-04-17 Stephen Burgess , Jeremy A Labrecque

Extending (generalizing or transporting) causal inferences from a randomized trial to a target population requires ``generalizability'' or ``transportability'' assumptions, which state that randomized and non-randomized individuals are…

We provide conditions for the stochastic dominance comparisons of a risk $X$ and an associated risk $X+Z$, where $Z$ represents the uncertainty due to the environment and where $X$ and $Z$ can be dependent. The comparisons depend on both…

统计理论 · 数学 2025-03-10 Jorge Navarro , José M. Zapata

Joint misclassification of exposure and outcome variables can lead to considerable bias in epidemiological studies of causal exposure-outcome effects. In this paper, we present a new maximum likelihood based estimator for the marginal…

统计方法学 · 统计学 2019-01-16 Bas B. L. Penning de Vries , Maarten van Smeden , Rolf H. H. Groenwold

Identifying effects of actions (treatments) on outcome variables from observational data and causal assumptions is a fundamental problem in causal inference. This identification is made difficult by the presence of confounders which can be…

统计方法学 · 统计学 2012-03-19 Ilya Shpitser , Tyler VanderWeele , James M. Robins

Causal inference with observational studies often suffers from unmeasured confounding, yielding biased estimators based on the unconfoundedness assumption. Sensitivity analysis assesses how the causal conclusions change with respect to…

统计方法学 · 统计学 2024-04-01 Sizhu Lu , Peng Ding

In clinical prediction modeling, model updating refers to the practice of modifying a prediction model before it is used in a new setting. In the context of logistic regression for a binary outcome, one of the simplest updating methods is a…

应用统计 · 统计学 2022-04-12 Mohsen Sadatsafavi , Hamid Tavakoli , Abdollah Safari

Conditional effect estimation has great scientific and policy importance because interventions may impact subjects differently depending on their characteristics. Most research has focused on estimating the conditional average treatment…

统计方法学 · 统计学 2023-04-25 Alec McClean , Zach Branson , Edward H. Kennedy

Problem definition: Mining for heterogeneous responses to an intervention is a crucial step for data-driven operations, for instance to personalize treatment or pricing. We investigate how to estimate price sensitivity from…

统计方法学 · 统计学 2025-01-08 Jean Pauphilet

Historically used in settings where the outcome is rare or data collection is expensive, outcome-dependent sampling is relevant to many modern settings where data is readily available for a biased sample of the target population, such as…

统计方法学 · 统计学 2022-07-20 Amanda Coston , Edward H. Kennedy

Difference-in-differences is undoubtedly one of the most widely used methods for evaluating the causal effect of an intervention in observational (i.e., nonrandomized) settings. The approach is typically used when pre- and post-exposure…

统计方法学 · 统计学 2023-08-21 Eric Tchetgen Tchetgen , Chan Park , David Richardson

This work is devoted to the study of the probability of immunity, i.e. the effect occurs whether exposed or not. We derive necessary and sufficient conditions for non-immunity and $\epsilon$-bounded immunity, i.e. the probability of…

统计方法学 · 统计学 2023-10-12 Jose M. Peña

The association between two random variables is often of primary interest in statistical research. In this paper semiparametric models for the association between random vectors X and Y are considered which leave the marginal distributions…

统计理论 · 数学 2012-04-16 Angelika Franke , Gerhard Osius

To answer questions of "causes of effects", the probability of necessity is introduced for assessing whether or not an observed outcome was caused by an earlier treatment. However, the statistical inference for probability of necessity is…

统计方法学 · 统计学 2025-04-14 Ping Zhang , Ruoyu Wang , Wang Miao

The case$^2$ study, also referred to as the case-case study design, is a valuable approach for conducting inference for treatment effects. Unlike traditional case-control studies, the case$^2$ design compares treatment in two types of cases…

统计方法学 · 统计学 2025-03-03 Kan Chen , Ting Ye , Dylan S. Small

When epidemiologic studies are conducted in a subset of the population, selection bias can threaten the validity of causal inference. This bias can occur whether or not that selected population is the target population, and can occur even…

统计方法学 · 统计学 2019-06-07 Louisa H. Smith , Tyler J. VanderWeele

Cohort studies employ pairwise measures of association to quantify dependencies among conditions and exposures. To reliably use these measures to draw conclusions about the underlying association strengths requires that the measures be…

定量方法 · 定量生物学 2017-05-30 Venkateshan Kannan , Kristina Alexandersson , Jesper Tegner

We propose in this work an original estimator of the conditional intensity of a marker-dependent counting process, that is, a counting process with covariates. We use model selection methods and provide a non asymptotic bound for the risk…

统计理论 · 数学 2008-10-24 F. Comte , S. Gaïffas , A. Guilloux

Drawing causal inference with observational studies is the central pillar of many disciplines. One sufficient condition for identifying the causal effect is that the treatment-outcome relationship is unconfounded conditional on the observed…

统计理论 · 数学 2017-01-17 Peng Ding , Tyler VanderWeele , James Robins

In observational studies, the recorded treatment assignment is not purely random, but it is influenced by external factors such as patient characteristics, reimbursement policies, and existing guidelines. Therefore, the treatment effect can…

统计方法学 · 统计学 2024-09-02 Sara Poletto , Enrico Longato , Erica Tavazzi , Martina Vettoretti