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The steady-state degree of a chemical reaction network is the number of complex steady-states, which is a measure of the algebraic complexity of solving the steady-state system. In general, the steady-state degree may be difficult to…

组合数学 · 数学 2020-04-27 Elizabeth Gross , Cvetelina Hill

An important invariant of a chemical reaction network is its maximum number of positive steady states. This number, however, is in general difficult to compute. Nonetheless, there is an upper bound on this number -- namely, a network's…

分子网络 · 定量生物学 2020-12-09 Nida Obatake , Anne Shiu , Dilruba Sofia

Chemical reaction network theory is a field of applied mathematics concerned with modeling chemical systems, and can be used in other contexts such as in systems biology to study cellular signaling pathways or epidemiology to study the…

Chemical reaction networks are often used to model and understand biological processes such as cell signaling. Under the framework of chemical reaction network theory, a process is modeled with a directed graph and a choice of kinetics,…

组合数学 · 数学 2020-12-07 Mark Curiel , Elizabeth Gross , Carlos Munoz

Many biochemical and industrial applications involve complicated networks of simultaneously occurring chemical reactions. Under the assumption of mass action kinetics, the dynamics of these chemical reaction networks are governed by systems…

动力系统 · 数学 2014-07-15 Matthew D. Johnston

We consider the problem of binomiality of the steady state ideals of biochemical reaction networks. We are interested in finding polynomial conditions on the parameters such that the steady state ideal of a chemical reaction network is…

分子网络 · 定量生物学 2021-07-08 Hamid Rahkooy , Thomas Sturm

This work addresses whether a reaction network, taken with mass-action kinetics, is multistationary, that is, admits more than one positive steady state in some stoichiometric compatibility class. We build on previous work on the effect…

分子网络 · 定量生物学 2019-08-27 AmirHosein Sadeghimanesh , Elisenda Feliu

Motivated by problems from Chemical Reaction Network Theory, we investigate whether steady state ideals of reversible reaction networks are generated by binomials. We take an algebraic approach considering, besides concentrations of…

符号计算 · 计算机科学 2020-10-22 Hamid Rahkooy , Ovidiu Radulescu , Thomas Sturm

Coupled cell systems are dynamical systems associated to a network and synchrony subspaces, given by balanced colorings of the network, are invariant subspaces for every coupled cell systems associated to that network. Golubitsky and…

动力系统 · 数学 2017-12-06 Pedro Soares

Bistability and multistationarity are properties of reaction networks linked to switch-like responses and connected to cell memory and cell decision making. Determining whether and when a network exhibits bistability is a hard and open…

代数几何 · 数学 2018-12-20 Elisenda Feliu , Martin Helmer

Steady state is an essential concept in reaction networks. Its stability reflects fundamental characteristics of several biological phenomena such as cellular signal transduction and gene expression. Because biochemical reactions occur at…

分子网络 · 定量生物学 2019-04-19 Tan Van Vu , Yoshihiko Hasegawa

It has been recently observed that the dynamical properties of mass action systems arising from many models of biochemical reaction networks can be derived by considering the corresponding properties of a related generalized mass action…

数值分析 · 数学 2014-07-22 Matthew D. Johnston

Mathematical and computational modelling of biochemical networks is often done in terms of either the concentrations of molecular species or the fluxes of biochemical reactions. When is mathematical modelling from either perspective…

分子网络 · 定量生物学 2015-12-10 Ronan M. T. Fleming , Nikos Vlassis , Ines Thiele , Michael A. Saunders

We establish that mass conserving single terminal-linkage networks of chemical reactions admit positive steady states regardless of network deficiency and the choice of reaction rate constants. This result holds for closed systems without…

分子网络 · 定量生物学 2015-03-19 Santiago Akle , Onkar Dalal , Ronan M. T. Fleming , Michael Saunders , Nicole Taheri , Yinyu Ye

Network translation has recently been used to establish steady state properties of mass action systems by corresponding the given system to a generalized one which is either dynamically or steady state equivalent. In this work we further…

动力系统 · 数学 2018-08-14 Elisa Tonello , Matthew D. Johnston

We introduce the notion of corresponding a chemical reaction network to a split network translation, and use this novel process to extend the scope of existing network-based theory for characterizing the steady state set of mass-action…

动力系统 · 数学 2021-04-09 Matthew D. Johnston

For dynamical systems arising from chemical reaction networks, persistence is the property that each species concentration remains positively bounded away from zero, as long as species concentrations were all positive in the beginning. We…

动力系统 · 数学 2016-07-29 Michael Marcondes de Freitas , Elisenda Feliu , Carsten Wiuf

Which reaction networks, when taken with mass-action kinetics, have the capacity for multiple steady states? There is no complete answer to this question, but over the last 40 years various criteria have been developed that can answer this…

动力系统 · 数学 2015-08-21 Badal Joshi , Anne Shiu

Here, steady-state reaction networks are inspected from the viewpoint of individual tagged molecules jumping among their chemical states upon the occurrence of reactive events. Such an agent-based viewpoint is useful for selectively…

化学物理 · 物理学 2022-05-16 Daniele Asnicar , Emanuele Penocchio , Diego Frezzato

The purpose of this paper is to present a network realization theory for a class of mixed quantum-classical linear stochastic systems. Two forms, the standard form and the general form, of this class of linear mixed quantum-classical…

量子物理 · 物理学 2018-05-24 Shi Wang , Hendra I. Nurdin , Guofeng Zhang , Matthew R. James
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