相关论文: Knowledge-Driven New Drug Recommendation

We tackle a novel few-shot learning challenge, which we call few-shot semantic edge detection, aiming to localize crisp boundaries of novel categories using only a few labeled samples. We also present a Class-Agnostic Few-shot Edge…

In silico drug-target interaction (DTI) prediction is an important and challenging problem in biomedical research with a huge potential benefit to the pharmaceutical industry and patients. Most existing methods for DTI prediction including…

Explainable recommendation is far from being well solved partly due to three challenges. The first is the personalization of preference learning, which requires that different items/users have different contributions to the learning of user…

Drug repositioning offers an effective solution to drug discovery, saving both time and resources by finding new indications for existing drugs. Typically, a drug takes effect via its protein targets in the cell. As a result, it is…

Modern machine learning tools have shown promise in detecting symptoms of neurological disorders. However, current approaches typically train a unique classifier for each subject. This subject-specific training scheme requires long labeled…

We consider the task of few shot link prediction on graphs. The goal is to learn from a distribution over graphs so that a model is able to quickly infer missing edges in a new graph after a small amount of training. We show that current…

Drug repurposing is an effective strategy to identify new uses for existing drugs, providing the quickest possible transition from bench to bedside. Existing methods for drug repurposing that mainly focus on pre-clinical information may…

Knowledge graphs suffer from sparsity which degrades the quality of representations generated by various methods. While there is an abundance of textual information throughout the web and many existing knowledge bases, aligning information…

Electronic Health Records (EHRs) have been increasingly used as real-world evidence (RWE) to support the discovery and validation of new drug indications. This paper surveys current approaches to EHR-based drug repurposing, covering data…

Many multi-genic systemic diseases such as neurological disorders, inflammatory diseases, and the majority of cancers do not have effective treatments yet. Reinforcement learning powered systems pharmacology is a potentially effective…

A knowledge graph (KG) consists of a set of interconnected typed entities and their attributes. Recently, KGs are popularly used as the auxiliary information to enable more accurate, explainable, and diverse user preference recommendations.…

Representation learning has overcome the often arduous and manual featurization of networks through (unsupervised) feature learning as it results in embeddings that can apply to a variety of downstream learning tasks. The focus of…

Precision medicine tailored to individual patients has gained significant attention in recent times. Machine learning techniques are now employed to process personalized data from various sources, including images, genetics, and…

In this paper, we propose a novel edge-labeling graph neural network (EGNN), which adapts a deep neural network on the edge-labeling graph, for few-shot learning. The previous graph neural network (GNN) approaches in few-shot learning have…

Although Graph Neural Networks (GNNs) have been successful in node classification tasks, their performance heavily relies on the availability of a sufficient number of labeled nodes per class. In real-world situations, not all classes have…

For Artificial Intelligence to have a greater impact in biology and medicine, it is crucial that recommendations are both accurate and transparent. In other domains, a neurosymbolic approach of multi-hop reasoning on knowledge graphs has…

Recently, contrastive learning has been applied to the sequential recommendation task to address data sparsity caused by users with few item interactions and items with few user adoptions. Nevertheless, the existing contrastive…

The appearance of a new dangerous and contagious disease requires the development of a drug therapy faster than what is foreseen by usual mechanisms. Many drug therapy developments consist in investigating through different clinical trials…

Drug similarity has been studied to support downstream clinical tasks such as inferring novel properties of drugs (e.g. side effects, indications, interactions) from known properties. The growing availability of new types of drug features…

Adverse drug events (ADEs) are a major safety issue in clinical trials. Thus, predicting ADEs is key to developing safer medications and enhancing patient outcomes. To support this effort, we introduce CT-ADE, a dataset for multilabel ADE…