相关论文: Knowledge-Driven New Drug Recommendation

Discovery gene-disease links is important in biology and medicine areas, enabling disease identification and drug repurposing. Machine learning approaches accelerate this process by leveraging biological knowledge represented in ontologies…

Deep learning techniques hold immense promise for advancing medical image analysis, particularly in tasks like image segmentation, where precise annotation of regions or volumes of interest within medical images is crucial but manually…

Anomaly detection has been considered under several extents of prior knowledge. Unsupervised methods do not require any labelled data, whereas semi-supervised methods leverage some known anomalies. Inspired by mixture-of-experts models and…

Knowledge graphs (KGs) represent connections and relationships between real-world entities. We propose a link prediction framework for KGs named Enrichment-Driven GrAph Reasoner (EDGAR), which infers new edges by mining entity-local rules.…

In the treatment of complex diseases, treatment regimens using a single drug often yield limited efficacy and can lead to drug resistance. In contrast, combination drug therapies can significantly improve therapeutic outcomes through…

Distributed representations of medical concepts have been used to support downstream clinical tasks recently. Electronic Health Records (EHR) capture different aspects of patients' hospital encounters and serve as a rich source for…

Rare genetic disease diagnosis faces critical challenges: insufficient patient data, inaccessible full genome sequencing, and the immense number of possible causative genes. These limitations cause prolonged diagnostic journeys,…

Automatic Sleep Staging study is presently done with the help of Electroencephalogram (EEG) signals. Recently, Deep Learning (DL) based approaches have enabled significant progress in this area, allowing for near-human accuracy in automated…

Embedding is a useful technique to project a high-dimensional feature into a low-dimensional space, and it has many successful applications including link prediction, node classification and natural language processing. Current approaches…

Training a neural network model that can quickly adapt to a new task is highly desirable yet challenging for few-shot learning problems. Recent few-shot learning methods mostly concentrate on developing various meta-learning strategies from…

Embedding knowledge graphs (KGs) into continuous vector spaces is a focus of current research. Combining such an embedding model with logic rules has recently attracted increasing attention. Most previous attempts made a one-time injection…

Current multi-instance learning algorithms for pathology image analysis often require a substantial number of Whole Slide Images for effective training but exhibit suboptimal performance in scenarios with limited learning data. In clinical…

The systematic discovery of effective drug combinations is a challenging problem in modern pharmacology, driven by the combinatorial growth of potential pairings and dosage configurations. Network medicine, modeling diseases and drugs as…

Many practical graph problems, such as knowledge graph construction and drug-drug interaction prediction, require to handle multi-relational graphs. However, handling real-world multi-relational graphs with Graph Neural Networks (GNNs) is…

Sequential recommendation systems model dynamic preferences of users based on their historical interactions with platforms. Despite recent progress, modeling short-term and long-term behavior of users in such systems is nontrivial and…

Knowledge graph embedding (KGE) has shown great potential in automatic knowledge graph (KG) completion and knowledge-driven tasks. However, recent KGE models suffer from high training cost and large storage space, thus limiting their…

Providing model-generated explanations in recommender systems is important to user experience. State-of-the-art recommendation algorithms - especially collaborative filtering (CF)-based approaches with shallow or deep models - usually work…

Medication recommendation is a crucial task for assisting physicians in making timely decisions from longitudinal patient medical records. However, real-world EHR data present significant challenges due to the presence of rarely observed…

One of the key challenges when developing a predictive model is the capability to describe the domain knowledge and the cause-effect relationships in a simple way. Decision rules are a useful and important methodology in this context,…

Link prediction for knowledge graphs aims to predict missing connections between entities. Prevailing methods are limited to a transductive setting and hard to process unseen entities. The recent proposed subgraph-based models provided…