相关论文: Knowledge-Driven New Drug Recommendation

Drug repurposing is more relevant than ever due to drug development's rising costs and the need to respond to emerging diseases quickly. Knowledge graph embedding enables drug repurposing using heterogeneous data sources combined with…

Repurposing existing drugs to treat new diseases is a cost-effective alternative to de novo drug development, but there are millions of potential drug-disease combinations to be considered with only a small fraction being viable. In silico…

Few-shot classification consists of learning a predictive model that is able to effectively adapt to a new class, given only a few annotated samples. To solve this challenging problem, meta-learning has become a popular paradigm that…

Few-shot learning aims at leveraging knowledge learned by one or more deep learning models, in order to obtain good classification performance on new problems, where only a few labeled samples per class are available. Recent years have seen…

In recent decades, traditional drug research and development have been facing challenges such as high cost, long timelines, and high risks. To address these issues, many computational approaches have been suggested for predicting the…

Interaction between pharmacological agents can trigger unexpected adverse events. Capturing richer and more comprehensive information about drug-drug interactions (DDI) is one of the key tasks in public health and drug development.…

Graph neural networks (GNNs) can efficiently process text-attributed graphs (TAGs) due to their message-passing mechanisms, but their training heavily relies on the human-annotated labels. Moreover, the complex and diverse local topologies…

Despite the advances made in visual object recognition, state-of-the-art deep learning models struggle to effectively recognize novel objects in a few-shot setting where only a limited number of examples are provided. Unlike humans who…

Solving cold-start problems is indispensable to provide meaningful recommendation results for new users and items. Under sparsely observed data, unobserved user-item pairs are also a vital source for distilling latent users' information…

We address the medication recommendation problem, which aims to recommend effective medications for a patient's current visit by utilizing information (e.g., diagnoses and procedures) given at the patient's current and past visits. While…

The success of deep learning models is heavily tied to the use of massive amount of labeled data and excessively long training time. With the emergence of intelligent edge applications that use these models, the critical challenge is to…

Humans are capable of learning new concepts from small numbers of examples. In contrast, supervised deep learning models usually lack the ability to extract reliable predictive rules from limited data scenarios when attempting to classify…

Pharmacovigilance and clinical decision support systems utilize structured drug safety data to guide medical practice. However, existing datasets frequently depend on terminologies such as MedDRA, which limits their semantic reasoning…

The cold-start problem is quite challenging for existing recommendation models. Specifically, for the new items with only a few interactions, their ID embeddings are trained inadequately, leading to poor recommendation performance. Some…

The polypharmacy side effect prediction problem considers cases in which two drugs taken individually do not result in a particular side effect; however, when the two drugs are taken in combination, the side effect manifests. In this work,…

Computer vision-based methods have valuable use cases in precision medicine, and recognizing facial phenotypes of genetic disorders is one of them. Many genetic disorders are known to affect faces' visual appearance and geometry. Automated…

Adverse drug events are a significant source of preventable harm, which has led to the development of automated pill recognition systems to enhance medication safety. Real-world deployment of these systems is hindered by visually complex…

We study the problem of detecting adverse drug events in electronic healthcare records. The challenge in this work is to aggregate heterogeneous data types involving diagnosis codes, drug codes, as well as lab measurements. An earlier…

Medical professionals frequently work in a data constrained setting to provide insights across a unique demographic. A few medical observations, for instance, informs the diagnosis and treatment of a patient. This suggests a unique setting…

Drug-target interaction (DTI) prediction has become a foundational task in drug repositioning, polypharmacology, drug discovery, as well as drug resistance and side-effect prediction. DTI identification using machine learning is gaining…