相关论文: Knowledge-Driven New Drug Recommendation

Teaching machines to recognize a new category based on few training samples especially only one remains challenging owing to the incomprehensive understanding of the novel category caused by the lack of data. However, human can learn new…

Relation-aware graph structure embedding is promising for predicting multi-relational drug-drug interactions (DDIs). Typically, most existing methods begin by constructing a multi-relational DDI graph and then learning relation-aware graph…

Predicting interactions among heterogenous graph structured data has numerous applications such as knowledge graph completion, recommendation systems and drug discovery. Often times, the links to be predicted belong to rare types such as…

In this work we present a deep learning approach to conduct hypothesis-free, transcriptomics-based matching of drugs for diseases. Our proposed neural network architecture is trained on approved drug-disease indications, taking as input the…

Knowledge graphs (KGs), containing many entity-relation-entity triples, provide rich information for downstream applications. Although extracting triples from unstructured texts has been widely explored, most of them require a large number…

Traditional drug discovery methods are costly and time-consuming. Drug repositioning (DR) is a common strategy to overcome these issues. Recently, machine learning methods have been used extensively in DR problem. The performance of these…

In order to quickly adapt to new data, few-shot learning aims at learning from few examples, often by using already acquired knowledge. The new data often differs from the previously seen data due to a domain shift, that is, a change of the…

In medical treatment and elsewhere, it has become standard to base treatment intensity (dosage) on evidence in randomized trials. Yet it has been rare to study how outcomes vary with dosage. In trials to obtain drug approval, the norm has…

Performance of recommender systems (RS) relies heavily on the amount of training data available. This poses a chicken-and-egg problem for early-stage products, whose amount of data, in turn, relies on the performance of their RS. On the…

Drug recommendation requires a deep understanding of individual patient context, especially for complex conditions like Parkinson's disease. While LLMs possess broad medical knowledge, they fail to capture the subtle nuances of actual…

The ensemble of deep neural networks has been shown, both theoretically and empirically, to improve generalization accuracy on the unseen test set. However, the high training cost hinders its efficiency since we need a sufficient number of…

Knowledge graph (KG) enhanced recommendation has demonstrated improved performance in the recommendation system (RecSys) and attracted considerable research interest. Recently the literature has adopted neural graph networks (GNNs) on the…

High failure rates in cardiac drug development necessitate virtual clinical trials via electrocardiogram (ECG) generation to reduce risks and costs. However, existing ECG generation models struggle to balance morphological realism with…

Advancements in wearable sensor technologies and the digitization of medical records have contributed to the unprecedented ubiquity of biomedical time series data. Data-driven models have tremendous potential to assist clinical diagnosis…

Entity linking aims to link ambiguous mentions to their corresponding entities in a knowledge base, which is significant and fundamental for various downstream applications, e.g., knowledge base completion, question answering, and…

Few-shot learning aims to adapt knowledge learned from previous tasks to novel tasks with only a limited amount of labeled data. Research literature on few-shot learning exhibits great diversity, while different algorithms often excel at…

Complex or co-existing diseases are commonly treated using drug combinations, which can lead to higher risk of adverse side effects. The detection of polypharmacy side effects is usually done in Phase IV clinical trials, but there are still…

In many practical few-shot learning problems, even though labeled examples are scarce, there are abundant auxiliary datasets that potentially contain useful information. We propose the problem of extended few-shot learning to study these…

A pharmacological effect of a drug on cells, organs and systems refers to the specific biochemical interaction produced by a drug substance, which is called its mechanism of action. Drug repositioning (or drug repurposing) is a fundamental…

Knowledge graphs represent factual knowledge about the world as relationships between concepts and are critical for intelligent decision making in enterprise applications. New knowledge is inferred from the existing facts in the knowledge…