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Neurological injuries predominantly result in loss of functioning of neurons. These neurons may regain function after particular medical therapeutics, such as Chondroitinase ABC (ChABC), that promote axon elongation by manipulating the…

最优化与控制 · 数学 2022-04-01 Cenk Demir , Shumon Koga , Miroslav Krstic

In this work, stabilization of an axonal growth in a neuron associated with the dynamics of tubulin concentration is proposed by designing a boundary control. The dynamics are given by a parabolic Partial Differential Equation (PDE) of the…

最优化与控制 · 数学 2021-09-30 Cenk Demir , Shumon Koga , Miroslav Krstic

Exploring novel strategies for the regulation of axon growth, we introduce a periodic event-triggered control (PETC) to enhance the practical implementation of the associated PDE backstepping control law. Neurological injuries may impair…

最优化与控制 · 数学 2024-05-01 Cenk Demir , Mamadou Diagne , Miroslav Krstic

A transport PDE with a spatial integral and recirculation with constant delay has been a benchmark for neural operator approximations of PDE backstepping controllers. Introducing a spatially-varying delay into the model gives rise to a gain…

系统与控制 · 电气工程与系统科学 2025-10-01 Jie Qi , Jiaqi Hu , Jing Zhang , Miroslav Krstic

The recently introduced DeepONet operator-learning framework for PDE control is extended from the results for basic hyperbolic and parabolic PDEs to an advanced hyperbolic class that involves delays on both the state and the system output…

最优化与控制 · 数学 2024-06-17 Jie Qi , Jing Zhang , Miroslav Krstic

The information of spiking neural networks (SNNs) are propagated between the adjacent biological neuron by spikes, which provides a computing paradigm with the promise of simulating the human brain. Recent studies have found that the time…

神经与进化计算 · 计算机科学 2022-05-05 Pengfei Sun , Longwei Zhu , Dick Botteldooren

We present a methodology for stabilization of general nonlinear systems with actuator dynamics governed by general, quasilinear, first-order hyperbolic PDEs. Since for such PDE-ODE cascades the speed of propagation depends on the PDE state…

最优化与控制 · 数学 2017-10-23 Nikolaos Bekiaris-Liberis , Miroslav Krstic

Deep neural networks that approximate nonlinear function-to-function mappings, i.e., operators, which are called DeepONet, have been demonstrated in recent articles to be capable of encoding entire PDE control methodologies, such as…

偏微分方程分析 · 数学 2023-08-22 Shanshan Wang , Mamadou Diagne , Miroslav Krstić

We present here the details of a backstepping transformation aiming at reformulating the dynamics of a nonlinear systems subject to unknown long input delay in a form which is suitable for Lyapunov stability analysis. The control law…

动力系统 · 数学 2013-05-24 Delphine Bresch-Pietri , Miroslav Krstic

In this paper, a delay compensation design method based on PDE backstepping is developed for a two-dimensional reaction-diffusion partial differential equation (PDE) with bilateral input delays. The PDE is defined in a rectangular domain,…

最优化与控制 · 数学 2023-07-10 Dandan Guan , Yanmei Chen , Jie Qi , Linglong Du

A backstepping-based compensator design is developed for a system of $2\times2$ first-order linear hyperbolic partial differential equations (PDE) in the presence of an uncertain long input delay at boundary. We introduce a transport PDE to…

最优化与控制 · 数学 2023-07-24 Jing Zhang , Jie Qi

We develop a delay-adaptive controller for a class of first-order hyperbolic partial integro-differential equations (PIDEs) with an unknown input delay. By employing a transport PDE to represent delayed actuator states, the system is…

偏微分方程分析 · 数学 2023-07-11 Shanshan Wang , Jie Qi , Miroslav Krstic

The effect of intrinsic channel noise is investigated for the dynamic response of a neuronal cell with a delayed feedback loop. The loop is based on the so-called autapse phenomenon in which dendrites establish not only connections to…

生物物理 · 物理学 2014-12-22 Yunyun Li , Gerhard Schmid , Peter Hanggi , Lutz Schimansky-Geier

We consider the effect of distributed delays in neural feedback systems. The avian optic tectum is reciprocally connected with the nucleus isthmi. Extracellular stimulation combined with intracellular recordings reveal a range of signal…

We introduce a dynamic event-triggering mechanism for regulating the axonal growth of a neuron. We apply boundary actuation at the soma (the part of a neuron that contains the nucleus) and regulate the dynamics of tubulin concentration and…

最优化与控制 · 数学 2024-03-19 Cenk Demir , Shumon Koga , Miroslav Krstic

Neuronal damage, in the form of both brain and spinal cord injuries, is one of the major causes of disability and death in young adults worldwide. One way to assess the direct damage occurring after a mechanical insult is the simulation of…

神经与进化计算 · 计算机科学 2024-09-20 Antonio LaTorre , Man Ting Kwong , Julián A. García-Grajales , Riyi Shi , Antoine Jérusalem , José-María Peña

Control of distributed parameter systems affected by delays is a challenging task, particularly when the delays depend on spatial variables. The idea of integrating analytical control theory with learning-based control within a unified…

人工智能 · 计算机科学 2025-01-31 Jiaqi Hu , Jie Qi , Jing Zhang

This paper introduces a novel approach to PDE boundary control design using neural operators to alleviate stop-and-go instabilities in congested traffic flow. Our framework leverages neural operators to design control strategies for traffic…

机器学习 · 计算机科学 2023-12-19 Yihuai Zhang , Ruiguo Zhong , Huan Yu

To stabilize PDEs, feedback controllers require gain kernel functions, which are themselves governed by PDEs. Furthermore, these gain-kernel PDEs depend on the PDE plants' functional coefficients. The functional coefficients in PDE plants…

系统与控制 · 电气工程与系统科学 2024-01-17 Maxence Lamarque , Luke Bhan , Yuanyuan Shi , Miroslav Krstic

Despite significant advances in understanding neuronal development, a fully quantitative framework that integrates intracellular mechanisms with environmental cues during axonal growth remains incomplete. Here, we present a unified…

神经元与认知 · 定量生物学 2025-05-26 Kyle Cheng , Udathari Kumarasinghe , Cristian Staii
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