相关论文: Effect of two vaccine doses in the SEIR epidemic m…
We study an optimal control problem for a non-autonomous SEIRS model with incidence given by a general function of the infective, the susceptible and the total population, and with vaccination and treatment as control variables. We prove…
This work consists of an epidemic model with vaccination coupled with an opinion dynamics. Our objective was to study how disease risk perception can influence opinions about vaccination and therefore the spreading of the disease.…
Early on during a pandemic, vaccine availability is limited, requiring prioritisation of different population groups. Evaluating vaccine allocation is therefore a crucial element of pandemics response. In the present work, we develop a…
We formalize and study the problem of optimal allocation strategies for a (perfect) vaccine in the infinite-dimensional SIS model. The question may be viewed as a bi-objective minimization problem, where one tries to minimize simultaneously…
Covid-19 has caused hundred of thousands of deaths and an economic damage amounting to trillions of dollars, creating a desire for the rapid development of vaccine. Once available, vaccine is gradually produced, evoking the question on how…
The study of epidemiological systems has generated deep interest in exploring the dynamical complexity of common infectious diseases driven by seasonally varying contact rates. Mathematical modeling and field observations have shown that,…
This paper investigates the effects of vaccination on the dynamics of infectious disease, which is spreading in a population concurrently with awareness. The model considers contributions to the overall awareness from a global information…
Modeling human behavior is essential to accurately predict epidemic spread, with behaviors like vaccine hesitancy complicating control efforts. While epidemic spread is often treated as a simple contagion, vaccine uptake may follow complex…
This study assesses the impact of COVID-19 vaccines through an epidemiological model that quantifies their role in pandemic control. We analyze an SIR-based model incorporating vaccination effects and calculate the basic reproduction…
To understand the impact of vaccination, we consider a SIVR (susceptible-infected-vaccinated-recovered) model which combines impulsive vaccination into the classical SIR model. The final size is firstly defined and estimated, and then the…
Dose optimization is a hallmark of Project Optimus for oncology drug development. The number of doses to include in a dose optimization study depends on the totality of evidence, which is often unclear in early-phase development. With equal…
We present a lattice gas cellular automaton (LGCA) to study spatial and temporal dynamics of an epidemic of SIR (susceptible-infected-removed) type. The automaton is fully discrete, i.e. space, time and number of individuals are discrete…
In this paper, we present a decision support framework for optimizing multiple aspects of vaccine distribution across a multitier cold chain network. We propose two multi-period optimization formulations within this framework: first to…
Using a stochastic Susceptible-Infected-Removed (SIR) meta-population model of disease transmission, we present analytical calculations and numerical simulations dissecting the interplay between stochasticity and the division of a…
The COVID-19 pandemic highlighted significant challenges in the allocation of vital healthcare resources. Existing epidemiological models, specifically compartmental models, aimed to predict the spread of the COVID-19 virus and its impact…
We study in a general mathematical framework the optimal allocation of vaccine in an heterogeneous population. We cast the problem of optimal vaccination as a bi-objective minimization problem min(C($\eta$),L($\eta$)), where C and L stand…
Effective strategies of vaccine prioritization are essential to mitigate the impacts of severe infectious diseases. We investigate the role of infection fatality ratio (IFR) and social contact matrices on vaccination prioritization using a…
The Covid-19 outbreak of 2020 has required many governments to develop and adopt mathematical-statistical models of the pandemic for policy and planning purposes. To this end, this work provides a tutorial on building a compartmental model…
In this paper, we present a discrete-time networked SEIR model using population flow, its derivation, and assumptions under which this model is well defined. We identify properties of the system's equilibria, namely the healthy states. We…
We formulate a generalized susceptible exposed infectious recovered (SEIR) model on a graph, describing the population dynamics of an open crowded place with an arbitrary topology. As a sample calculation, we discuss three simple cases,…