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According to the World Health Organization(WHO), malaria is estimated to have killed 627,000 people and infected over 241 million people in 2020 alone, a 12% increase from 2019. Microscopic diagnosis of blood cells is the standard testing…

图像与视频处理 · 电气工程与系统科学 2022-08-15 Rohan Sangameswaran

For two genotypes that have the same mean number of offspring but differ in the variance in offspring number, natural selection will favor the genotype with lower variance. The concept of fitness becomes cloudy under these conditions…

种群与进化 · 定量生物学 2007-05-23 Max Shpak , Stephen Proulx

Estimation of stillbirth rates globally is complicated because of the paucity of reliable data from countries where most stillbirths occur. We compiled data and developed a Bayesian hierarchical temporal sparse regression model for…

This paper investigates whether associations between birth weight and prenatal ambient environmental conditions--pollution and extreme temperatures--differ by 1) maternal education; 2) children's innate health; and 3) interactions between…

综合经济学 · 经济学 2022-04-04 Xiaoying Liu , Jere R. Behrman , Emily Hannum , Fan Wang , Qingguo Zhao

Human populations have undergone dramatic changes in population size in the past 100,000 years, including a severe bottleneck of non-African populations and recent explosive population growth. There is currently great interest in how these…

种群与进化 · 定量生物学 2013-05-10 Yuval B. Simons , Michael C. Turchin , Jonathan K. Pritchard , Guy Sella

This research examines the simultaneous influences of height and weight on longitudinally measured systolic and diastolic blood pressure in children. Previous studies have shown that both height and weight are positively associated with…

应用统计 · 统计学 2013-01-15 Hai Liu , Wanzhu Tu

Objective: Cause-of-death distributions are important for prioritising interventions. We estimated proportions, risks, and numbers of deaths (with uncertainty) for programme-relevant causes of neonatal death for 194 countries for 2000-2013,…

应用统计 · 统计学 2014-11-17 Shefali Oza , Joy E Lawn , Daniel R Hogan , Colin Mathers , Simon Cousens

Empirical birthrate estimates for pulsar binaries depend on the fraction of sky subtended by the pulsar beam: the pulsar beaming fraction. This fraction depends on both the pulsar's opening angle and the misalignment angle between its spin…

星系天体物理 · 物理学 2010-10-25 Richard O'Shaughnessy , Chunglee Kim

Perinatal epidemiology often aims to evaluate exposures on infant outcomes. When the exposure affects the composition of people who give birth to live infants (e.g., by affecting fertility, behavior, or birth outcomes), this "live birth…

统计方法学 · 统计学 2024-01-23 Shalika Gupta , Laura B. Balzer , Moses R. Kamya , Diane V. Havlir , Maya L. Petersen

A recent cohort study revealed a positive correlate between major structural birth defects in infants and a certain medication taken by pregnant women. To draw valid causal inference, an outstanding problem to overcome was the missing birth…

应用统计 · 统计学 2022-06-09 Andrew Ying , Ronghui Xu , Christina D. Chambers , Kenneth Lyons Jones

Medical machine learning algorithms are typically evaluated based on accuracy vs. a clinician-defined ground truth, a reasonable initial choice since trained clinicians are usually better classifiers than ML models. However, this metric…

机器学习 · 计算机科学 2024-05-21 Charles B. Delahunt , Courosh Mehanian , Matthew P. Horning

In observational causal inference, in order to emulate a randomized experiment, weights are used to render treatments independent of observed covariates. This property is known as balance; in its absence, estimated causal effects may be…

统计方法学 · 统计学 2020-07-16 David Arbour , Drew Dimmery , Arjun Sondhi

Measurement error in observational datasets can lead to systematic bias in inferences based on these datasets. As studies based on observational data are increasingly used to inform decisions with real-world impact, it is critical that we…

机器学习 · 统计学 2019-01-29 Roy Adams , Yuelong Ji , Xiaobin Wang , Suchi Saria

Causal inference in observational studies typically requires making comparisons between groups that are dissimilar. For instance, researchers investigating the role of a prolonged duration of breastfeeding on child outcomes may be forced to…

应用统计 · 统计学 2013-12-02 Jennifer Hill , Yu-Sung Su

There is effect modification if the magnitude or stability of a treatment effect varies systematically with the level of an observed covariate. A larger or more stable treatment effect is typically less sensitive to bias from unmeasured…

应用统计 · 统计学 2016-12-12 Kwonsang Lee , Dylan S. Small , Jesse Y. Hsu , Jeffrey H. Silber , Paul R. Rosenbaum

Many observational studies feature irregular longitudinal data, where the observation times are not common across individuals in the study. Further, the observation times may be related to the longitudinal outcome. In this setting, failing…

统计方法学 · 统计学 2024-05-27 Grace Tompkins , Joel A Dubin , Michael Wallace

Childhood obesity is a major public health concern. Multidisciplinary pediatric weight management programs are considered standard treatment for children with obesity and severe obesity who are not able to be successfully managed in the…

机器学习 · 计算机科学 2022-03-08 Hamed Fayyaz , Thao-Ly T. Phan , H. Timothy Bunnell , Rahmatollah Beheshti

Childhood anemia affects around 40% of children aged 6-59 months globally and arises from heterogeneous factors, limiting model generalizability. We evaluate a transformer-based tabular foundation model against classical supervised methods…

Experimental animal evidence and a growing body of observational studies suggest that prenatal exposure to phthalates may be a risk factor for childhood obesity. Using data from the Mount Sinai Children's Environmental Health Study…

统计方法学 · 统计学 2025-10-21 Phuc H. Nguyen , Stephanie M. Engel , Amy H. Herring

Malaria parasites are known to mediate the induction of inflammatory immune responses at the maternal-foetal interface during placental malaria (PM) leading to adverse consequences like pre-term deliveries and abortions. Immunological…