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An algorithm is given in this paper for the computation of dynamically equivalent weakly reversible realizations with the maximal number of reactions, for chemical reaction networks (CRNs) with mass action kinetics.

动力系统 · 数学 2015-03-19 Gabor Szederkenyi , Katalin M. Hangos , Zsolt Tuza

Networks of model neurons with balanced recurrent excitation and inhibition produce irregular and asynchronous spiking activity. We extend the analysis of balanced networks to include the known dependence of connection probability on the…

神经元与认知 · 定量生物学 2014-06-02 Robert Rosenbaum , Brent Doiron

A multistationarity region is the part of a reaction network's parameter space that gives rise to multiple steady states. Mathematically, this region consists of the positive parameters for which a parametrized family of polynomial…

动力系统 · 数学 2024-04-08 Allison McClure , Anne Shiu

Motivated by recent progress on the interplay between graph theory, dynamics, and systems theory, we revisit the analysis of chemical reaction networks described by mass action kinetics. For reaction networks possessing a thermodynamic…

最优化与控制 · 数学 2012-06-19 Arjan van der Schaft , Shodhan Rao , Bayu Jayawardhana

We present three examples of chemical reaction networks whose ordinary differential equation scaling limit are almost identical and in all cases stable. Nevertheless, the Markov jump processes associated to these reaction networks display…

概率论 · 数学 2018-10-16 Andrea Agazzi , Jonathan C. Mattingly

The quantitative convergence to equilibrium for reaction-diffusion systems arising from complex balanced chemical reaction networks with mass action kinetics is studied by using the so-called entropy method. In the first part of the paper,…

偏微分方程分析 · 数学 2016-11-11 Laurent Desvillettes , Klemens Fellner , Bao Quoc Tang

We consider scaling laws for maximal energy efficiency of communicating a message to all the nodes in a wireless network, as the number of nodes in the network becomes large. Two cases of large wireless networks are studied -- dense random…

信息论 · 计算机科学 2009-05-26 Aman Jain , Sanjeev R. Kulkarni , Sergio Verdu

The optimal coordination rates are determined in three primary settings of multi-user quantum networks, thus characterizing the minimal resources required in order to simulate a joint quantum state among multiple parties. We study the…

量子物理 · 物理学 2025-02-28 Hosen Nator , Uzi Pereg

Stochasticity plays important roles in molecular networks when molecular concentrations are in the range of $0.1 \mu$M to $10 n$M (about 100 to 10 copies in a cell). The chemical master equation provides a fundamental framework for studying…

分子网络 · 定量生物学 2013-03-14 Youfang Cao , Jie Liang

In systems and synthetic biology, much research has focused on the behavior and design of single pathways, while, more recently, experimental efforts have focused on how cross-talk (coupling two or more pathways) or inhibiting molecular…

动力系统 · 数学 2019-08-15 Elizabeth Gross , Heather A Harrington , Nicolette Meshkat , Anne Shiu

Quantum coherence is a key element in topical research on quantum resource theories and a primary facilitator for design and implementation of quantum technologies. However, the resourcefulness of quantum coherence is severely restricted by…

量子物理 · 物理学 2015-06-01 Uttam Singh , Manabendra Nath Bera , Himadri Shekhar Dhar , Arun Kumar Pati

Under mass-action kinetics, complex-balanced systems emerge from biochemical reaction networks and exhibit stable and predictable dynamics. For a reaction network $G$, the associated dynamical system is called $\textit{disguised toric}$ if…

分子网络 · 定量生物学 2024-12-04 Gheorghe Craciun , Abhishek Deshpande , Jiaxin Jin

External flows of energy, entropy, and matter can cause sudden transitions in the stability of biological and industrial systems, fundamentally altering their dynamical function. How might we control and design these transitions in chemical…

分子网络 · 定量生物学 2023-06-19 Zachary G. Nicolaou , Schuyler B. Nicholson , Adilson E. Motter , Jason R. Green

We define a subclass of Chemical Reaction Networks called Post-Translational Modification systems. Important biological examples of such systems include MAPK cascades and two-component systems which are well-studied experimentally as well…

分子网络 · 定量生物学 2011-07-19 Elisenda Feliu , Carsten Wiuf

Based on the theory of stochastic chemical kinetics, the inherent randomness and stochasticity of biochemical reaction networks can be accurately described by discrete-state continuous-time Markov chains. The analysis of such processes is,…

数值分析 · 数学 2014-10-14 Andreychenko Alexander , Mikeev Linar , Wolf Verena

Complex networks, comprised of individual elements that interact with each other through reaction channels, are ubiquitous across many scientific and engineering disciplines. Examples include biochemical, pharmacokinetic, epidemiological,…

数学物理 · 物理学 2013-06-14 John Goutsias , Garrett Jenkinson

Many reaction networks arising in applications are multistationary, that is, they have the capacity for more than one steady state; while some networks exhibit absolute concentration robustness (ACR), which means that some species…

动力系统 · 数学 2024-11-20 Nidhi Kaihnsa , Tung Nguyen , Anne Shiu

We present a computational procedure to characterize the signs of sensitivities of steady states to parameter perturbations in chemical reaction networks.

定量方法 · 定量生物学 2013-12-31 Eduardo D. Sontag

The stability of a complex system generally decreases with increasing system size and interconnectivity, a counterintuitive result of widespread importance across the physical, life, and social sciences. Despite recent interest in the…

种群与进化 · 定量生物学 2020-05-20 A. Bradley Duthie

Higher cumulants of conserved charges are sensitive observables of quantum chromodynamics phase transitions. The sample of mixed events provides a background to estimate non-critical effects of cumulants. Four possible methods for…

高能物理 - 唯象学 · 物理学 2019-09-04 Fan Zhang , Zhiming Li , Lizhu Chen , Xue Pan , Mingmei Xu , Yeyin Zhao , Yu Zhou , Yuanfang Wu