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A plethora of computational models have been developed in recent decades to account for the morphogenesis of complex biological fluid networks, such as capillary beds. Contemporary adaptation models are based on optimization schemes where…

组织与器官 · 定量生物学 2021-11-16 Felix Kramer , Carl D. Modes

A stochastic reaction-diffusion model is studied on a networked support. In each patch of the network two species are assumed to interact following a non-normal reaction scheme. When the interaction unit is replicated on a directed linear…

We study the dynamics of a simple adaptive system in the presence of noise and periodic damping. The system is composed by two paths connecting a source and a sink, the dynamics is governed by equations that usually describe food search of…

统计力学 · 物理学 2021-12-23 Frederic Folz , Kurt Mehlhorn , Giovanna Morigi

We show that a neural network originally designed for language processing can learn the dynamical rules of a stochastic system by observation of a single dynamical trajectory of the system, and can accurately predict its emergent behavior…

统计力学 · 物理学 2022-02-18 Corneel Casert , Isaac Tamblyn , Stephen Whitelam

The influence of an intramolecular proton transfer reaction on the conductance of a molecular junction is investigated employing a generic model, which includes the effects of the electric field of the gate and leads electrodes and the…

介观与纳米尺度物理 · 物理学 2017-03-08 Chriszandro Hofmeister , Pedro B. Coto , Michael Thoss

The concept of control is crucial for effectively understanding and applying biological network models. Key structural features relate to control functions through gene regulation, signaling, or metabolic mechanisms, and computational…

Ferromagnetic substrates can significantly influence the electromagnetic response of a coated conductor to an external magnetic field and transport current. This study analyzes this response theoretically using the thin shell…

超导电性 · 物理学 2025-04-22 Vladimir Sokolovsky , Leonid Prigozhin

Predicting cellular metabolic states is a central problem in biophysics. Conventional approaches, however, sensitively depend on the microscopic details of individual metabolic systems. In this Letter, we derived a universal linear…

分子网络 · 定量生物学 2023-07-26 Jumpei F. Yamagishi , Tetsuhiro S. Hatakeyama

Robustness of biochemical systems has become one of the central questions in systems biology although it is notoriously difficult to formally capture its multifaceted nature. Maintenance of normal system function depends not only on the…

分子网络 · 定量生物学 2012-03-28 Jost Neigenfind , Sergio Grimbs , Zoran Nikoloski

Chemical reaction rates must increasingly be determined in systems that evolve under the control of external stimuli. In these systems, when a reactant population is induced to cross an energy barrier through forcing from a temporally…

化学物理 · 物理学 2015-05-01 Galen T. Craven , Thomas Bartsch , Rigoberto Hernandez

The response of nonlinear resonators to multifrequency driving reveals rich dynamics beyond conventional single-tone theory. We study a Duffing resonator under bichromatic excitation and identify a competition between the two drives,…

介观与纳米尺度物理 · 物理学 2026-03-17 Soumya S. Kumar , Javier del Pino , Letizia Catalini , Alexander Eichler , Oded Zilberberg

Changing some of its parameters over time is a paradigmatic way of driving an otherwise isolated many-body quantum system out of equilibrium, and a vital ingredient for building quantum computers and simulators. Here, we further develop a…

量子物理 · 物理学 2024-11-06 Lennart Dabelow , Peter Reimann

The ubiquity of modules in biological networks may result from an evolutionary benefit of a modular organization. For instance, modularity may increase the rate of adaptive evolution, because modules can be easily combined into new…

分子网络 · 定量生物学 2011-08-26 Areejit Samal , Andreas Wagner , Olivier C. Martin

By a refinement of the technique used by Johnson and Zumbrun to show stability under localized perturbations, we show that spectral stability implies nonlinear modulational stability of periodic traveling-wave solutions of reaction…

偏微分方程分析 · 数学 2015-05-28 Mathew Johnson , Pascal Noble , L. Miguel Rodrigues , Kevin Zumbrun

Many biological molecular motors and machines are driven by chemical reactions that occur in specific catalytic sites. We study whether the arrival of molecules to such an active site can be accelerated by the presence of a nearby inactive…

统计力学 · 物理学 2025-01-06 Hila Katznelson , Saar Rahav

Stochastic models of biochemical reaction networks are widely used to capture intrinsic noise in cellular systems. The typical formulation of these models are based on Markov processes for which there is extensive research on efficient…

分子网络 · 定量生物学 2025-12-03 Thomas P. Steele , David J. Warne

We study electron pumping in the strong coupling and non-Markovian regime. Our model is a single quantum dot with periodically modulated energy and tunnelling amplitudes. We identify four parameters to control the direction of the current:…

量子物理 · 物理学 2019-08-27 Sebastian Restrepo , Sina Böhling , Javier Cerrillo , Gernot Schaller

This study proposes an effective theoretical framework for non-adiabatic parametric excitation in structured media, incorporating a nonlinear frequency regulator U as a stabilizing mechanism. We introduce the non-adiabaticity parameter as a…

介观与纳米尺度物理 · 物理学 2026-05-19 A. M. Tishin

Gene regulatory circuits show significant stochastic fluctuations in their circuit signals due to the low copy number of transcription factors. When a gene circuit component is connected to an existing circuit, the dynamic properties of the…

定量方法 · 定量生物学 2009-10-30 Kyung Hyuk Kim , Herbert M. Sauro

Understanding the function of network motifs in an attempt to gain insight into how their combinations create larger reaction networks that drive cellular functions, has been a longstanding pursuit of systems biology. One specific objective…

分子网络 · 定量生物学 2025-09-24 Nguyen H. N. Tran , Federico Frascoli , Andrew H. A. Clayton