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The biopharmaceutical industry is increasingly developing digital twins to digitalize and automate the manufacturing process in response to the growing market demands. However, this shift presents significant challenges for human operators,…

人机交互 · 计算机科学 2025-04-02 Mohammed Aatif Shahab , Francesco Destro , Richard D. Braatz

A digital twin is a virtual replica of a real-world physical phenomena that uses mathematical modeling to characterize and simulate its defining features. By constructing digital twins for disease processes, we can perform in-silico…

Digital Twins (DTs) are computational models that simulate the states and temporal dynamics of real-world systems, playing a crucial role in prediction, understanding, and decision-making across diverse domains. However, existing approaches…

机器学习 · 计算机科学 2024-11-01 Samuel Holt , Tennison Liu , Mihaela van der Schaar

Digital twins (DTs) are redefining healthcare by paving the way for more personalized, proactive, and intelligent medical interventions. As the shift toward personalized care intensifies, there is a growing need for an individual's virtual…

人机交互 · 计算机科学 2025-03-18 Melvin Mokhtari

Chronic diseases constitute the principal burden of morbidity, mortality, and healthcare costs worldwide, yet current health systems remain fragmented and predominantly reactive. Patient Medical Digital Twins (PMDTs) offer a paradigm shift:…

软件工程 · 计算机科学 2026-02-13 Micheal P. Papazoglou , Bernd J. Krämer , Mira Raheem , Amal Elgammal

Digital twins are emerging as a valuable tool for short-term decision-making as well as for long-term strategic planning across numerous domains, including process industry, energy, space, transport, and healthcare. This paper reports on…

Recent technological advances have expanded the availability of high-throughput biological datasets, enabling the reliable design of digital twins of biomedical systems or patients. Such computational tools represent key reaction networks…

定量方法 · 定量生物学 2025-09-03 Clémence Métayer , Annabelle Ballesta , Julien Martinelli

Static solutions don't serve a dynamic mind. Thus, we advocate a shift from static mental health diagnostic assessments to continuous, artificial intelligence (AI)-driven assessment. Focusing on Attention-Deficit/Hyperactivity Disorder…

人工智能 · 计算机科学 2025-10-10 Neil Natarajan , Sruthi Viswanathan , Xavier Roberts-Gaal , Michelle Marie Martel

Digital Twin technology is an emerging concept that has become the centre of attention for industry and, in more recent years, academia. The advancements in industry 4.0 concepts have facilitated its growth, particularly in the…

计算机与社会 · 计算机科学 2020-06-19 Aidan Fuller , Zhong Fan , Charles Day , Chris Barlow

Recently there has been a surge of interest in developing Digital Twins of process flows in healthcare to better understand bottlenecks and areas of improvement. A key challenge is in the validation process. We describe a work in progress…

Healthcare artificial intelligence systems often degrade in performance when deployed across institutions, with documented performance drops and perpetuation of discriminatory patterns embedded in data. This brittleness comes, in part, from…

机器学习 · 计算机科学 2026-03-30 Munib Mesinovic , Max Buhlan , Tingting Zhu

Serving as an emerging and powerful tool, Large Language Model (LLM)-driven Human Digital Twins are showing great potential in healthcare system research. However, its actual simulation ability for complex human psychological traits, such…

人机交互 · 计算机科学 2025-12-11 Yuzhou Wu , Mingyang Wu , Di Liu , Rong Yin , Kang Li

Remarkable success of modern image-based AI methods and the resulting interest in their applications in critical decision-making processes has led to a surge in efforts to make such intelligent systems transparent and explainable. The need…

人工智能 · 计算机科学 2020-11-30 Adriano Lucieri , Muhammad Naseer Bajwa , Andreas Dengel , Sheraz Ahmed

The damage and the impact of natural disasters are becoming more destructive with the increase of urbanization. Today's metropolitan cities are not sufficiently prepared for the pre and post-disaster situations. Digital Twin technology can…

人工智能 · 计算机科学 2021-04-01 Özgür Dogan , Oguzhan Sahin , Enis Karaarslan

As artificial intelligence (AI) becomes increasingly embedded in healthcare delivery, this chapter explores the critical aspects of developing reliable and ethical Clinical Decision Support Systems (CDSS). Beginning with the fundamental…

Recent advancements in AI applications to healthcare have shown incredible promise in surpassing human performance in diagnosis and disease prognosis. With the increasing complexity of AI models, however, concerns regarding their opacity,…

机器学习 · 计算机科学 2023-08-17 Munib Mesinovic , Peter Watkinson , Tingting Zhu

Digital pathology is not only one of the most promising fields of diagnostic medicine, but at the same time a hot topic for fundamental research. Digital pathology is not just the transfer of histopathological slides into digital…

Despite the Digital Twin (DT) concept being in the industry for a long time, it remains ambiguous, unable to differentiate itself from information models, general computing, and simulation technologies. Part of this confusion stems from…

人机交互 · 计算机科学 2022-12-06 Ashwin Agrawal , Vishal Singh , Martin Fischer

Research has shown that the general health and oral health of an individual are closely related. Accordingly, current practice of isolating the information base of medical and oral health domains can be dangerous and detrimental to the…

人工智能 · 计算机科学 2014-04-01 Tejal Shah , Fethi Rabhi , Pradeep Ray , Kerry Taylor

A digital twin is a powerful tool that can help monitor and optimize physical assets in real-time. Simply put, it is a virtual representation of a physical asset, enabled through data and simulators, that can be used for a variety of…

计算机视觉与模式识别 · 计算机科学 2023-03-01 Elias Mohammed Elfarri , Adil Rasheed , Omer San