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Dynamical system models of complex biochemical reaction networks are usually high-dimensional, nonlinear, and contain many unknown parameters. In some cases the reaction network structure dictates that positive equilibria must be unique for…

动力系统 · 数学 2008-09-09 Gheorghe Craciun , J. William Helton , Ruth J. Williams

A method for integrating the chemical equations associated with nuclear combustion at high temperature is presented and extensively checked. Following the idea of E. M\"uller, the feedback between nuclear rates and temperature was taken…

天体物理学 · 物理学 2007-05-23 Ruben M. Cabezon Gomez , Domingo Garcia-Senz , Eduardo Bravo

This study addresses the vital role of data analytics in monitoring fertiliser applications in crop cultivation. Inaccurate fertiliser application decisions can lead to costly consequences, hinder food production, and cause environmental…

机器学习 · 计算机科学 2023-10-19 Usama Ikhlaq , Tahar Kechadi

A detailed understanding of biochemical networks at the molecular level is essential for studying complex cellular processes. In this paper, we provide a comprehensive description of biochemical networks by considering individual atoms and…

分子网络 · 定量生物学 2025-04-08 Hadjar Rahou , Hulda S. Haraldsdottir , Filippo Martinelli , Ines Thiele , Ronan M. T. Fleming

Regular nutrient intake monitoring in hospitalised patients plays a critical role in reducing the risk of disease-related malnutrition (DRM). Although several methods to estimate nutrient intake have been developed, there is still a clear…

Although ordinary differential equations (ODEs) provide insights for designing network architectures, its relationship with the non-residual convolutional neural networks (CNNs) is still unclear. In this paper, we present a novel ODE model…

机器学习 · 统计学 2020-08-18 Zonghan Yang , Yang Liu , Chenglong Bao , Zuoqiang Shi

We define a subclass of Chemical Reaction Networks called Post-Translational Modification systems. Important biological examples of such systems include MAPK cascades and two-component systems which are well-studied experimentally as well…

分子网络 · 定量生物学 2011-07-19 Elisenda Feliu , Carsten Wiuf

Stochastic reaction networks are mathematical models with a wide range of applications in biochemistry, ecology, and epidemiology, and are often complex to analyze. Except for some special cases, it is generally difficult to predict how the…

概率论 · 数学 2026-04-02 Daniele Cappelletti , Giulio Cuniberti , Paola Siri

The inverse problem of supervised reconstruction of depth-variable (time-dependent) parameters in a neural ordinary differential equation (NODE) is considered, that means finding the weights of a residual network with time continuous…

机器学习 · 计算机科学 2022-02-14 George Baravdish , Gabriel Eilertsen , Rym Jaroudi , B. Tomas Johansson , Lukáš Malý , Jonas Unger

Application of nonlinearity continuation method to numerical solution of steady-state groundwater flow in variably saturated conditions is presented. In order to solve the system of nonlinear equations obtained by finite volume…

数值分析 · 数学 2020-08-04 Denis Anuprienko , Ivan Kapyrin

We introduce OS-net (Orbitally Stable neural NETworks), a new family of neural network architectures specifically designed for periodic dynamical data. OS-net is a special case of Neural Ordinary Differential Equations (NODEs) and takes…

动力系统 · 数学 2023-09-27 Marieme Ngom , Carlo Graziani

Living cells display a remarkable capacity to compartmentalize their functional biochemistry. A particularly fascinating example is the cell nucleus. Exchange of macromolecules between the nucleus and the surrounding cytoplasm does not…

亚细胞过程 · 定量生物学 2017-04-19 Ching-Hao Wang , Pankaj Mehta , Michael Elbaum

Increasing the layer number of on-chip photonic neural networks (PNNs) is essential to improve its model performance. However, the successively cascading of network hidden layers results in larger integrated photonic chip areas. To address…

机器学习 · 计算机科学 2023-02-08 Yun Zhao , Hang Chen , Min Lin , Haiou Zhang , Tao Yan , Xing Lin , Ruqi Huang , Qionghai Dai

The continuous dynamics of natural systems has been effectively modelled using Neural Ordinary Differential Equations (Neural ODEs). However, for accurate and meaningful predictions, it is crucial that the models follow the underlying rules…

机器学习 · 计算机科学 2024-03-06 C. Coelho , M. Fernanda P. Costa , L. L. Ferrás

This paper presents a novel framework for the modeling of biological networks. It makes use of recent tools analyzing the robust satisfaction of properties of (hybrid) dynamical systems. The main challenge of this approach as applied to…

计算工程、金融与科学 · 计算机科学 2012-08-22 Nicolas Mobilia , Alexandre Donzé , Jean Marc Moulis , Éric Fanchon

Analyzing qualitative behaviors of biochemical reactions using its associated network structure has proven useful in diverse branches of biology. As an extension of our previous work, we introduce a graph-based framework to calculate steady…

经典分析与常微分方程 · 数学 2014-04-28 Inom Mirzaev , David Matthew Bortz

The detailed balance property is a fundamental property that must be satisfied in all the macroscopic systems with a well defined temperature at each point. On the other hand, many biochemical networks work in non-equilibrium conditions and…

经典分析与常微分方程 · 数学 2025-02-10 E. Franco , J. J. L. Velázquez

Model reduction for fluid flow simulation continues to be of great interest across a number of scientific and engineering fields. Here, we explore the use of Neural Ordinary Differential Equations, a recently introduced family of…

机器学习 · 计算机科学 2021-04-30 Sourav Dutta , Peter Rivera-Casillas , Matthew W. Farthing

In this study, we investigate the complexity of two-phase flow (air/water) in a heterogeneous soil sample by using complex network theory, where the supposed porous media is non-deformable media, under the time-dependent gas pressure. Based…

计算工程、金融与科学 · 计算机科学 2010-08-11 Hamed. O. Ghaffari , Mamdou Fall , Erman. Evgin

We identify the thermodynamic conditions necessary to observe indefinite growth in homogeneous open chemical reaction networks (CRNs) satisfying mass action kinetics. We also characterize the thermodynamic efficiency of growth by…

分子网络 · 定量生物学 2024-12-05 Shesha Gopal Marehalli Srinivas , Francesco Avanzini , Massimiliano Esposito