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Host-pathogen interactions consist of an attack by the pathogen, frequently a defense by the host and possibly a counter-defense by the pathogen. Here, we present a game-theoretical approach to describing such interactions. We consider a…

定量方法 · 定量生物学 2024-09-10 Shalu Dwivedi , Ravindra Garde , Stefan Schuster

Prokaryotes have evolved various mechanisms to counter viruses, which in their turn developed numerous strategies to avoid defenses of the hosts. Dozens of such defense and counter-defense mechanisms have recently been discovered, yet the…

种群与进化 · 定量生物学 2025-08-04 Yaroslav Ispolatov , Anna Lekontseva , Konstantin Severinov

We introduce a model called Host-Pathogen game for studying biological competitions. Notably, we focus on the invasive dynamics of external agents, like bacteria, within a host organism. The former are mapped to a population of defectors…

种群与进化 · 定量生物学 2018-09-03 Marco Alberto Javarone

Adversarial machine learning, i.e., increasing the robustness of machine learning algorithms against so-called adversarial examples, is now an established field. Yet, newly proposed methods are evaluated and compared under unrealistic…

机器学习 · 计算机科学 2021-09-28 Maximilian Samsinger , Florian Merkle , Pascal Schöttle , Tomas Pevny

We study defense strategies against reward poisoning attacks in reinforcement learning. As a threat model, we consider attacks that minimally alter rewards to make the attacker's target policy uniquely optimal under the poisoned rewards,…

机器学习 · 计算机科学 2021-06-22 Kiarash Banihashem , Adish Singla , Goran Radanovic

The development of reliable methods for restoring susceptibility after antibiotic resistance arises has proven elusive. A greater understanding of the relationship between antibiotic administration and the evolution of resistance is key to…

种群与进化 · 定量生物学 2014-06-09 Portia M. Mira , Kristina Crona , Devin Greene , Juan C. Meza , Bernd Sturmfels , Miriam Barlow

Inspired by scenarios where the strategic network design and defense or immunisation are of the central importance, Goyal et al. [3] defined a new Network Formation Game with Attack and Immunisation. The authors showed that despite the…

计算机科学与博弈论 · 计算机科学 2023-02-13 Carme Àlvarez , Arnau Messegué

The adaptive immune system provides a diverse set of molecules that can mount specific responses against a multitude of pathogens. Memory is a key feature of adaptive immunity, which allows organisms to respond more readily upon…

种群与进化 · 定量生物学 2021-04-14 Oskar H Schnaack , Armita Nourmohammad

One strategy for winning a coevolutionary struggle is to evolve rapidly. Most of the literature on host-pathogen coevolution focuses on this phenomenon, and looks for consequent evidence of coevolutionary arms races. An alternative…

种群与进化 · 定量生物学 2012-11-14 Erick Chastain , Rustom Antia , Carl T. Bergstrom

Adversarial dynamics are a critical facet within the cyber security domain, in which there exists a co-evolution between attackers and defenders in any given threat scenario. While defenders leverage capabilities to minimize the potential…

密码学与安全 · 计算机科学 2014-08-19 Michael L. Winterrose , Kevin M. Carter

In a distributed system with {\it attacks} and {\it defenses,} both {\it attackers} and {\it defenders} are self-interested entities. We assume a {\it reward-sharing} scheme among {\it interdependent} defenders; each defender wishes to…

计算机科学与博弈论 · 计算机科学 2008-12-23 Marios Mavronicolas , Burkhard Monien , Vicky Papadopoulou

One strategy for winning a coevolutionary struggle is to evolve rapidly. Most of the literature on host-pathogen coevolution focuses on this phenomenon, and looks for consequent evidence of coevolutionary arms races. An alternative…

种群与进化 · 定量生物学 2014-12-17 Erick Chastain , Rustom Antia , Carl T. Bergstrom

We establish some properties of a within host mathematical model of malaria proposed by Recker et al which includes the role of the immune system during the infection. The model accounts for the antigenic variation exhibited by the malaria…

细胞行为 · 定量生物学 2007-08-01 Patrick De Leenheer , Sergei S. Pilyugin

We propose a scheme for defending against adversarial attacks by suppressing the largest eigenvalue of the Fisher information matrix (FIM). Our starting point is one explanation on the rationale of adversarial examples. Based on the idea of…

机器学习 · 计算机科学 2019-09-16 Chaomin Shen , Yaxin Peng , Guixu Zhang , Jinsong Fan

As large language models grow increasingly capable, concerns about their safe deployment have intensified. While numerous alignment strategies aim to restrict harmful behavior, these defenses can still be circumvented through carefully…

计算与语言 · 计算机科学 2026-05-05 Xinbo Wu , Huan Zhang , Abhishek Umrawal , Lav R. Varshney

In Stackelberg security games when information about the attacker's payoffs is uncertain, algorithms have been proposed to learn the optimal defender commitment by interacting with the attacker and observing their best responses. In this…

计算机科学与博弈论 · 计算机科学 2019-11-01 Jiarui Gan , Qingyu Guo , Long Tran-Thanh , Bo An , Michael Wooldridge

There are various examples of phenotypic plasticity in ecosystems that serve as the basis for a wide range of inducible defences against predation. These strategies include camouflage, burrowing, mimicry, evasive actions, and even…

种群与进化 · 定量生物学 2025-01-06 Sangeeta Saha , Swadesh Pal , Roderick Melnik

Many microbes live in habitats below their optimum temperature. Retention of metabolic heat by aggregation or insulation would boost growth. Generation of excess metabolic heat may also provide benefit. A cell that makes excess metabolic…

种群与进化 · 定量生物学 2020-10-22 Steven A. Frank

We develop a time and space dependent predator-prey model. The predators' equation is a non local hyperbolic balance law, while the diffusion of prey obeys a parabolic equation, so that predators "hunt" for prey, while prey diffuse. A…

偏微分方程分析 · 数学 2020-04-01 Rinaldo M. Colombo , Elena Rossi

This paper proposes a game-theoretic method to address the problem of optimal detector placement in a networked control system under cyber-attacks. The networked control system is composed of interconnected agents where each agent is…

系统与控制 · 电气工程与系统科学 2023-12-05 Anh Tung Nguyen , Sribalaji C. Anand , André M. H. Teixeira , Alexander Medvedev
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