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Many biological systems can be modeled as a chemical reaction network with unknown parameters. Data available to identify these parameters are often in the form of a stationary distribution, such as that obtained from measurements of a cell…

系统与控制 · 电气工程与系统科学 2023-09-14 Theodore W. Grunberg , Domitilla Del Vecchio

Chemical reaction networks (CRNs) are a standard formalism used in chemistry and biology to reason about the dynamics of molecular interaction networks. In their interpretation by ordinary differential equations, CRNs provide a…

定量方法 · 定量生物学 2020-07-28 Mathieu Hemery , François Fages , Sylvain Soliman

Due to the limitations of Moore's Law and the increasing demand of computing, optical neural network (ONNs) are gradually coming to the stage as an alternative to electrical neural networks. The control of nonlinear activation functions in…

光学 · 物理学 2025-05-13 Zili Cai , Tian Zhang , Jian Dai , Zheng Wang , Kun Xu

Stochastic reaction networks are dynamical models of biochemical reaction systems and form a particular class of continuous-time Markov chains on $\mathbb{N}^n$. Here we provide a fundamental characterisation that connects structural…

概率论 · 数学 2018-05-22 Daniele Cappelletti , Carsten Wiuf

We propose a fully autonomous, thermodynamically consistent set of chemical reactions that implements a spiking neuron. This chemical neuron is able to learn input patterns in a Hebbian fashion. The system is scalable to arbitrarily many…

神经与进化计算 · 计算机科学 2020-09-29 Jakub Fil , Dominique Chu

In this work, we design a type of controller that consists of adding a specific set of reactions to an existing mass-action chemical reaction network in order to control a target species. This set of reactions is effective for both…

分子网络 · 定量生物学 2020-07-27 Jinsu Kim , German Enciso

The coefficient sequences of multivariate rational functions appear in many areas of combinatorics. Their diagonal coefficient sequences enjoy nice arithmetic and asymptotic properties, and the field of analytic combinatorics in several…

符号计算 · 计算机科学 2020-11-19 Stephen Melczer , Bruno Salvy

Neural networks achieve outstanding accuracy in classification and regression tasks. However, understanding their behavior still remains an open challenge that requires questions to be addressed on the robustness, explainability and…

机器学习 · 计算机科学 2021-05-13 Anna-Kathrin Kopetzki , Stephan Günnemann

This paper analyses of a stochastic model of a chemical reaction network with three types of chemical species ${\cal R}$, ${\cal M}$ and ${\cal U}$ that interact to transform a flow of external resources, the chemical species ${\cal Q}$, to…

概率论 · 数学 2025-12-01 Vincent Fromion , Philippe Robert , Jana Zaherddine

Reaction networks have become a major modelling framework in the biological sciences from epidemiology and population biology to genetics and cellular biology. In recent years, much progress has been made on stochastic reaction networks…

概率论 · 数学 2025-08-14 Linard Hoessly , Carsten Wiuf , Panqiu Xia

Networks are fundamental building blocks for representing data, and computations. Remarkable progress in learning in structurally defined (shallow or deep) networks has recently been achieved. Here we introduce evolutionary exploratory…

神经与进化计算 · 计算机科学 2019-11-05 Rise Ooi , Chao-Han Huck Yang , Pin-Yu Chen , Vìctor Eguìluz , Narsis Kiani , Hector Zenil , David Gomez-Cabrero , Jesper Tegnèr

The question of what kind of convolutional neural network (CNN) structure performs well is fascinating. In this work, we move toward the answer with one more step by connecting zero stability and model performance. Specifically, we found…

机器学习 · 计算机科学 2022-06-28 Liangming Chen , Long Jin , Mingsheng Shang

If $(X^N)_{N=1,2,...}$ is a sequence of Markov processes which solve the martingale problems for some operators $(G^N)_{N=1,2,...}$, it is a classical task to derive a limit result as $N\to\infty$, in particular a weak process limit with…

概率论 · 数学 2021-12-01 Timo Enger , Peter Pfaffelhuber

Experiments with networks of discrete reactive bistable electrochemical elements organized in regular and nonregular tree networks are presented to confirm an alternative to the Turing mechanism for the formation of self-organized…

斑图形成与孤子 · 物理学 2016-11-15 N. E. Kouvaris , M. Sebek , A. S. Mikhailov , I. Z. Kiss

This paper is concerned with the utilization of deterministically modeled chemical reaction networks for the implementation of (feed-forward) neural networks. We develop a general mathematical framework and prove that the ordinary…

神经与进化计算 · 计算机科学 2021-03-10 David F. Anderson , Badal Joshi , Abhishek Deshpande

Elicitable functionals and (strictly) consistent scoring functions are of interest due to their utility of determining (uniquely) optimal forecasts, and thus the ability to effectively backtest predictions. However, in practice, assuming…

统计方法学 · 统计学 2026-03-18 Kathleen E. Miao , Silvana M. Pesenti

We present two quantitative behavioral equivalences over species of a chemical reaction network (CRN) with semantics based on ordinary differential equations. Forward CRN bisimulation identifies a partition where each equivalence class…

计算机科学中的逻辑 · 计算机科学 2015-07-16 Luca Cardelli , Mirco Tribastone , Max Tschaikowski , Andrea Vandin

A chemical reaction mechanism (CRM) is a sequence of molecular-level events involving bond-breaking/forming processes, generating transient intermediates along the reaction pathway as reactants transform into products. Understanding such…

化学物理 · 物理学 2024-07-16 Ajnabiul Hoque , Manajit Das , Mayank Baranwal , Raghavan B. Sunoj

Insufficient capability of existing subspace clustering methods to handle data coming from nonlinear manifolds, data corruptions, and out-of-sample data hinders their applicability to address real-world clustering and classification…

计算机视觉与模式识别 · 计算机科学 2020-04-08 Dario Sitnik , Ivica Kopriva

Control barrier functions (CBFs) have been demonstrated as an effective method for safety-critical control of autonomous systems. Although CBFs are simple to deploy, their design remains challenging, motivating the development of…

机器人学 · 计算机科学 2026-03-10 Bojan Derajić , Sebastian Bernhard , Wolfgang Hönig