相关论文: Emergence of oscillations in a mixed-mechanism pho…

Phosphorylation networks, representing the mechanisms by which proteins are phosphorylated at one or multiple sites, are ubiquitous in cell signalling and display rich dynamics such as unlimited multistability. Dual-site phosphorylation…

Ordered distributive double phosphorylation is a recurrent motif in intracellular signaling and control. It is either sequential (where the site phosphorylated last is dephosphorylated first) or cyclic (where the site phosphorylated first…

This work concerns the question of how two important dynamical properties, oscillations and bistability, emerge in an important biological signaling network. Specifically, we consider a model for dual-site phosphorylation and…

Protein phosphorylation cycles are important mechanisms of the post translational modification of a protein and as such an integral part of intracellular signaling and control. We consider the sequential phosphorylation and…

We study the emergence of periodic oscillations through a Hopf bifurcation in a scalar diffusion equation on the half line coupled to a dynamic boundary condition. Our results quantify the effect of delay through the buffering in the…

Nonlinear phenomena including multiple equilibria and spontaneous oscillations are common in fluid networks containing either multiple phases or constituent flows. In many systems, such behavior might be attributed to the complicated…

In this work we prove occurrence of a super-critical Hopf bifurcation in a model of white blood cell formation structured by three maturation stages. We provide an explicit analytical expression for the bifurcation point depending on model…

We present a result concerning the mean value of orbits emerging from Hopf bifurcations. We then apply this result to identify a new phenomenon termed {\it oscillation-induced gain modulation}. A Hopf bifurcation of a system $\dot{x} = f(x;…

We report an experimental study of the dynamics of an air-fluidized thin granular layer. Near-onset behavior of this shallow fluidized bed was described in the earlier paper (Tsimring et al, 1999). Above the threshold of fluidization the…

Biofilm communities of Bacillus subtilis bacteria have recently been shown to exhibit collective growth-rate oscillations mediated by electrochemical signaling to cope with nutrient starvation. These oscillations emerge once the colony…

In aggregation-fragmentation processes, a steady state is usually reached in the long time limit. This indicates the existence of a fixed point in the underlying system of ordinary differential equations. The next simplest possibility is an…

We consider a model of extracellular signal-regulated kinase (ERK) regulation by dual-site phosphorylation and dephosphorylation, which exhibits bistability and oscillations, but loses these properties in the limit in which the mechanisms…

Hydrodynamic instabilities often cause spatio-temporal pattern formations and transitions between them. We investigate a model experimental system, a density oscillator, where the bifurcation from a resting state to an oscillatory state is…

We study the dynamics of belief formation on multiple interconnected topics in networks of agents with a shared belief system. We establish sufficient conditions and necessary conditions under which sustained oscillations of beliefs arise…

Cluster synchronization is a fundamental phenomenon in systems of coupled oscillators. Here, we investigate clustering patterns that emerge in a unidirectional ring of four delay-coupled electrochemical oscillators. A voltage parameter in…

We investigate the laminar flow of two-fluid mixtures inside a simple network of inter-connected tubes. The fluid system is comprised of two miscible Newtonian fluids of different viscosity which do not mix and remain as nearly distinct…

For many physical systems the transition from a stationary solution to sustained small amplitude oscillations corresponds to a Hopf bifurcation. For systems involving impacts, thresholds, switches, or other abrupt events, however, this…

Polymerization of microtubules is ubiquitous in biological cells and under certain conditions it becomes oscillatory in time. Here simple reaction models are analyzed that capture such oscillations as well as the length distribution of…

We investigate a diffusive, stage-structured epidemic model with the maturation delay and freely-moving delay. Choosing delays and diffusive rates as bifurcation parameters, the only possible way to destabilize the endemic equilibrium is…

We state two sufficient criteria for periodic oscillations in mass action systems. Neither criterion requires a computation of the Hurwitz determinants. Instead, both criteria exploit the linear algebra concepts of $D$-stability and…