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Cryo-electron microscopy is a revolutionary technique that can provide 3D density maps at near-atomic resolution. However, map validation is still an open issue in the field. Despite several efforts from the community, it is possible to…

Single-particle cryo-electron microscopy (cryo-EM) is a leading technology to resolve the structure of molecules. Early in the process, the user detects potential particle images in the raw data. Typically, there are many false detections…

图像与视频处理 · 电气工程与系统科学 2023-03-08 Gili Weiss-Dicker , Amitay Eldar , Yoel Shkolinsky , Tamir Bendory

We consider an uncertain linear inverse problem as follows. Given observation $\omega=Ax_*+\zeta$ where $A\in {\bf R}^{m\times p}$ and $\zeta\in {\bf R}^{m}$ is observation noise, we want to recover unknown signal $x_*$, known to belong to…

统计理论 · 数学 2025-02-07 Yannis Bekri , Anatoli Juditsky , Arkadi Nemirovski

The relationship between mappings of sets and renormalization group transformations is established, and renormalization group invariants of such mappings are found. These results are valid both for continuous and discrete mappings and for…

数学物理 · 物理学 2007-05-23 Gennady N. Nikolaev

In the context of agent based modeling and network theory, we focus on the problem of recovering behavior-related choice information from origin-destination type data, a topic also known under the name of network tomography. As a basis for…

物理与社会 · 物理学 2015-08-24 Tiziano Squartini , Enrico Ser-Giacomi , Diego Garlaschelli , George Judge

Understanding protein flexibility and its dynamic interactions with other molecules is essential for studying protein function. Although cryogenic electron microscopy(cryo-EM) provides an opportunity to observe macromolecular dynamics…

计算机视觉与模式识别 · 计算机科学 2026-02-03 Bintao He , Yiran Cheng , Hongjia Li , Xiang Gao , Xin Gao , Fa Zhang , Renmin Han

We revisit the topic of common lines between projection images in single particle cryo-electron microscopy (cryo-EM). We derive a novel low-rank constraint on a certain $2n \times n$ matrix storing properly-scaled basis vectors for the…

最优化与控制 · 数学 2024-06-10 Tommi Muller , Adriana L. Duncan , Eric J. Verbeke , Joe Kileel

In Gaussian graphical model selection, noise-corrupted samples present significant challenges. It is known that even minimal amounts of noise can obscure the underlying structure, leading to fundamental identifiability issues. A recent line…

机器学习 · 统计学 2024-05-09 Abrar Zahin , Rajasekhar Anguluri , Lalitha Sankar , Oliver Kosut , Gautam Dasarathy

Cryogenic electron microscopy (cryo-EM) provides a unique opportunity to study the structural heterogeneity of biomolecules. Being able to explain this heterogeneity with atomic models would help our understanding of their functional…

Low-rank matrix recovery problems involving high-dimensional and heterogeneous data appear in applications throughout statistics and machine learning. The contribution of this paper is to establish the fundamental limits of recovery for a…

机器学习 · 统计学 2022-03-22 Joshua K. Behne , Galen Reeves

Packing and covering problems for metric spaces, and graphs in particular, are of essential interest in combinatorics and coding theory. They are formulated in terms of metric balls of vertices. We consider a new problem in graph theory…

组合数学 · 数学 2011-10-25 Vladimir Levenshtein , Johannes Siemons

This paper considers the model problem of reconstructing an object from incomplete frequency samples. Consider a discrete-time signal $f \in \C^N$ and a randomly chosen set of frequencies $\Omega$ of mean size $\tau N$. Is it possible to…

数值分析 · 数学 2007-05-23 Emmanuel Candes , Justin Romberg , Terence Tao

The population recovery problem is a basic problem in noisy unsupervised learning that has attracted significant research attention in recent years [WY12,DRWY12, MS13, BIMP13, LZ15,DST16]. A number of different variants of this problem have…

数据结构与算法 · 计算机科学 2017-03-07 Anindya De , Ryan O'Donnell , Rocco Servedio

We consider the problem of recovering linear image $Bx$ of a signal $x$ known to belong to a given convex compact set ${\cal X}$ from indirect observation $\omega=Ax+\xi$ of $x$ corrupted by random noise $\xi$ with finite covariance matrix.…

统计理论 · 数学 2019-03-19 Anatoli Juditsky , Arkadi Nemirovski

Characterising the noise of an airborne electromagnetic (AEM) system is critical in correctly imaging the earth's subsurface conductivity. Deterministic and probabilistic geophysical inversion algorithms require foreknowledge of the system…

地球物理 · 物理学 2026-05-06 Tim Scarr , Anandaroop Ray , Ross C. Brodie

Motivated by the problem of determining the atomic structure of macromolecules using single-particle cryo-electron microscopy (cryo-EM), we study the sample and computational complexities of the sparse multi-reference alignment (MRA) model:…

信息论 · 计算机科学 2021-09-27 Tamir Bendory , Oscar Mickelin , Amit Singer

We introduce $Recursive~Jigsaw~Reconstruction$, a technique for analyzing reconstructed particle interactions in the presence of kinematic and combinatoric unknowns associated with unmeasured and indistinguishable particles, respectively.…

高能物理 - 唯象学 · 物理学 2017-12-27 Paul Jackson , Christopher Rogan

This paper considers the problem of estimating an unknown high dimensional signal from noisy linear measurements, {when} the signal is assumed to possess a \emph{group-sparse} structure in a {known,} fixed dictionary. We consider signals…

Multi-reference alignment (MRA) is the problem of recovering a signal from its multiple noisy copies, each acted upon by a random group element. MRA is mainly motivated by single-particle cryo-electron microscopy (cryo-EM) that has recently…

信息论 · 计算机科学 2023-08-15 Tamir Bendory , Dan Edidin

We suggest a new algorithm to estimate representations of compact Lie groups from finite samples of their orbits. Different from other reported techniques, our method allows the retrieval of the precise representation type as a direct sum…

最优化与控制 · 数学 2025-09-23 Henrique Ennes , Raphaël Tinarrage