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Cryo-electron microscopy (cryo-EM) is a widely used technique for recovering the 3-D structure of biological molecules from a large number of experimentally generated noisy 2-D tomographic projection images of the 3-D structure, taken from…

数值分析 · 数学 2025-11-17 Jeremy Hoskins , Yuehaw Khoo , Oscar Mickelin , Amit Singer , Yuguan Wang

We develop a novel real-space renormalization group (RG) scheme which accurately estimates correlation length exponent $\nu$ near criticality of higher-dimensional quantum Ising and Potts models in a transverse field. Our method is…

统计力学 · 物理学 2014-02-05 Aleksander Kubica , Beni Yoshida

Identifying when different images are of the same object despite changes caused by imaging technologies, or processes such as growth, has many applications in fields such as computer vision and biological image analysis. One approach to…

计算机视觉与模式识别 · 计算机科学 2016-08-12 Stephen Marsland , Robert McLachlan

We develop a novel method for detection of signals and reconstruction of images in the presence of random noise. The method uses results from percolation theory. We specifically address the problem of detection of multiple objects of…

应用统计 · 统计学 2013-12-02 Mikhail Langovoy , Michael Habeck , Bernhard Schölkopf

Invariance to nuisance transformations is one of the desirable properties of effective representations. We consider transformations that form a \emph{group} and propose an approach based on kernel methods to derive local group invariant…

机器学习 · 计算机科学 2017-05-25 Anant Raj , Abhishek Kumar , Youssef Mroueh , P. Thomas Fletcher , Bernhard Schölkopf

Cryo-electron microscopy (cryo-EM) is an emerging experimental method to characterize the structure of large biomolecular assemblies. Single particle cryo-EM records 2D images (so-called micrographs) of projections of the three-dimensional…

应用统计 · 统计学 2013-12-02 Mikhail Langovoy , Michael Habeck , Bernhard Schoelkopf

The problem of learning structural equation models (SEMs) from data is a fundamental problem in causal inference. We develop a new algorithm --- which is computationally and statistically efficient and works in the high-dimensional regime…

机器学习 · 计算机科学 2019-01-30 Asish Ghoshal , Jean Honorio

We consider the multi-target detection problem of recovering a set of signals that appear multiple times at unknown locations in a noisy measurement. In the low noise regime, one can estimate the signals by first detecting occurrences, then…

信息论 · 计算机科学 2020-01-08 Tamir Bendory , Nicolas Boumal , William Leeb , Eitan Levin , Amit Singer

Single-particle electron cryomicroscopy is an essential tool for high-resolution 3D reconstruction of proteins and other biological macromolecules. An important challenge in cryo-EM is the reconstruction of non-rigid molecules with parts…

图像与视频处理 · 电气工程与系统科学 2021-05-31 Amit Moscovich , Amit Halevi , Joakim Andén , Amit Singer

Tomographic reconstruction of a binary image from few projections is considered. A novel {\em heuristic} algorithm is proposed, the central element of which is a nonlinear transformation $\psi(p)=\log(p/(1-p))$ of the probability $p$ that a…

经典物理 · 物理学 2013-09-05 Stephane Roux , Hugo Leclerc , François Hild

Non-conservative uncertainty bounds are key for both assessing an estimation algorithm's accuracy and in view of downstream tasks, such as its deployment in safety-critical contexts. In this paper, we derive a tight, non-asymptotic…

机器学习 · 计算机科学 2026-01-16 Amon Lahr , Johannes Köhler , Anna Scampicchio , Melanie N. Zeilinger

Cryo-electron microscopy (cryo-EM) is an imaging modality that provides unique insights into the dynamics of proteins and other building blocks of life. The algorithmic challenge of jointly estimating the poses, 3D structure, and…

计算机视觉与模式识别 · 计算机科学 2022-10-17 Axel Levy , Gordon Wetzstein , Julien Martel , Frederic Poitevin , Ellen D. Zhong

A proof-of-concept framework for identifying molecules of unknown elemental composition and structure using experimental rotational data and probabilistic deep learning is presented. Using a minimal set of input data determined…

化学物理 · 物理学 2020-07-01 Michael C. McCarthy , Kin Long Kelvin Lee

The generalized phase retrieval problem over compact groups aims to recover a set of matrices -- representing an unknown signal -- from their associated Gram matrices. This framework generalizes the classical phase retrieval problem, which…

信号处理 · 电气工程与系统科学 2025-11-20 Tal Amir , Tamir Bendory , Nadav Dym , Dan Edidin

Cryo-electron tomography (cryoET) is a technique that captures images of biological samples at different tilts, preserving their native state as much as possible. Along with the partial tilt series and noise, one of the major challenges in…

信号处理 · 电气工程与系统科学 2023-07-26 Vinith Kishore , Valentin Debarnot , Ivan Dokmanić

Cryo-electron microscopy (cryo-EM) enables single-particle analysis of biological macromolecules under strict low-dose imaging conditions, but the resulting micrographs often exhibit extremely low signal-to-noise ratios and weak particle…

计算机视觉与模式识别 · 计算机科学 2026-04-21 Xiaoqi Wu , Xueying Zhan , Wen Li , Junhao Wu , Xin Huang , Min Xu

Many geometric estimation problems take the form of synchronization over the special Euclidean group: estimate the values of a set of poses given noisy measurements of a subset of their pairwise relative transforms. This problem is…

机器人学 · 计算机科学 2017-02-13 David M. Rosen , Luca Carlone , Afonso S. Bandeira , John J. Leonard

The expectation-maximization (EM) algorithm is an iterative method for finding maximum likelihood estimates when data are incomplete or are treated as being incomplete. The EM algorithm and its variants are commonly used for parameter…

统计计算 · 统计学 2013-06-26 Ryan P. Browne , Sanjeena Subedi , Paul McNicholas

We introduced and analyzed robust recovery-based a posteriori error estimators for various lower order finite element approximations to interface problems in [9, 10], where the recoveries of the flux and/or gradient are implicit (i.e.,…

数值分析 · 数学 2014-07-17 Zhiqiang Cai , Shun Zhang

Single-particle cryo-electron microscopy (cryo-EM) is an emerging imaging modality capable of visualizing proteins and macro-molecular complexes at near-atomic resolution. The low electron-doses used to prevent sample radiation damage,…

图像与视频处理 · 电气工程与系统科学 2020-11-24 Qinwen Huang , Ye Zhou , Xiaochen Du , Reed Chen , Jianyou Wang , Cynthia Rudin , Alberto Bartesaghi