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Rare events have played an increasing role in molecular phylogenetics as potentially homoplasy-poor characters.In this contribution we analyze the phylogenetic information content from a combinatorial point of view by consid-ering the…

离散数学 · 计算机科学 2017-06-15 Marc Hellmuth , Maribel Hernandez-Rosales , Yangjing Long , Peter F. Stadler

Phylogenomics heavily relies on well-curated sequence data sets that consist, for each gene, exclusively of 1:1-orthologous. Paralogs are treated as a dangerous nuisance that has to be detected and removed. We show here that this severe…

A major problem for inferring species trees from gene trees is that evolutionary processes can sometimes favour gene tree topologies that conflict with an underlying species tree. In the case of incomplete lineage sorting, this phenomenon…

种群与进化 · 定量生物学 2012-12-03 Mike Steel , Simone Linz , Daniel H. Huson , Michael J. Sanderson

Horizontal gene transfer events partition a gene tree $T$ and thus, its leaf set into subsets of genes whose evolutionary history is described by speciation and duplication events alone. Indirect phylogenetic methods can be used to infer…

离散数学 · 计算机科学 2021-12-02 David Schaller , Marc Hellmuth , Peter F. Stadler

Rooted phylogenetic networks provide an explicit representation of the evolutionary history of a set $X$ of sampled species. In contrast to phylogenetic trees which show only speciation events, networks can also accommodate reticulate…

组合数学 · 数学 2021-01-01 Peter L. Erdos , Charles Semple , Mike Steel

Reconciling a gene tree with a species tree is an important task that reveals much about the evolution of genes, genomes, and species, as well as about the molecular function of genes. A wide array of computational tools have been devised…

种群与进化 · 定量生物学 2012-12-11 Yun Yu , Luay Nakhleh

Phylogenetic networks are an extension of phylogenetic trees which are used to represent evolutionary histories in which reticulation events (such as recombination and hybridization) have occurred. A central question for such networks is…

种群与进化 · 定量生物学 2018-03-28 Andrew Francis , Vincent Moulton

Binary relations derived from labeled rooted trees play an import role in mathematical biology as formal models of evolutionary relationships. The (symmetrized) Fitch relation formalizes xenology as the pairs of genes separated by at least…

离散数学 · 计算机科学 2023-06-22 Marc Hellmuth , Carsten R. Seemann , Peter F. Stadler

Estimating phylogenetic trees is an important problem in evolutionary biology, environmental policy and medicine. Although trees are estimated, their uncertainties are discarded by mathematicians working in tree space. Here we explicitly…

统计方法学 · 统计学 2017-10-16 Amy D. Willis , Rayna C. Bell

Phylogenetic trees and networks are graphs used to model evolutionary relationships, with trees representing strictly branching histories and networks allowing for events in which lineages merge, called reticulation events. While the…

种群与进化 · 定量生物学 2026-04-17 Martin Frohn , Niels Holtgrefe , Leo van Iersel , Mark Jones , Steven Kelk

Orthology and paralogy relations are often inferred by methods based on gene similarity, which usually yield a graph depicting the relationships between gene pairs. Such relation graphs are known to frequently contain errors, as they cannot…

数据结构与算法 · 计算机科学 2022-02-16 Mark Jones , Manuel Lafond , Celine Scornavacca

Evolutionary scenarios describing the evolution of a family of genes within a collection of species comprise the mapping of the vertices of a gene tree $T$ to vertices and edges of a species tree $S$. The relative timing of the last common…

种群与进化 · 定量生物学 2023-08-03 David Schaller , Tom Hartmann , Manuel Lafond , Nicolas Wieseke , Peter F. Stadler , Marc Hellmuth

We compare the phylogenetic tensors for various trees and networks for two, three and four taxa. If the probability spaces between one tree or network and another are not identical then there will be phylogenetic tensors that could have…

种群与进化 · 定量生物学 2016-06-24 Jonathan Mitchell

Two genes are xenologs in the sense of Fitch if they are separated by at least one horizontal gene transfer event. Horizonal gene transfer is asymmetric in the sense that the transferred copy is distinguished from the one that remains…

离散数学 · 计算机科学 2018-02-13 Manuela Geiß , John Anders , Peter F. Stadler , Nicolas Wieseke , Marc Hellmuth

In phylogenetics, a central problem is to infer the evolutionary relationships between a set of species $X$; these relationships are often depicted via a phylogenetic tree -- a tree having its leaves univocally labeled by elements of $X$…

数据结构与算法 · 计算机科学 2016-04-12 Julien Baste , Christophe Paul , Ignasi Sau , Celine Scornavacca

As researchers collect increasingly large molecular data sets to reconstruct the Tree of Life, the heterogeneity of signals in the genomes of diverse organisms poses challenges for traditional phylogenetic analysis. A class of phylogenetic…

种群与进化 · 定量生物学 2015-09-11 Liang Liu , Zhenxiang Xi , Shaoyuan Wu , Charles Davis , Scott V. Edwards

Lateral gene transfer (LGT) is a common mechanism of non-vertical evolution where genetic material is transferred between two more or less distantly related organisms. It is particularly common in bacteria where it contributes to adaptive…

概率论 · 数学 2012-06-18 Sebastien Roch , Sagi Snir

In a population with haploid reproduction any individual has a single parent in the previous generation. If all genealogical distances among pairs of individuals (generations from the closest common ancestor) are known it is possible to…

种群与进化 · 定量生物学 2015-05-13 Luce Prignano , Maurizio Serva

Given a gene-tree labeled topology $G$ and a species tree $S$, the "ancestral configurations" at an internal node $k$ of $S$ represent the combinatorially different sets of gene lineages that can be present at $k$ when all possible…

In this study, we investigate the problem of comparing gene trees reconciled with the same species tree using a novel semi-metric, called the Path-Label Reconciliation (PLR) dissimilarity measure. This approach not only quantifies…