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This work presents a population genetic model of evolution, which includes haploid selection, mutation, recombination, and drift. The mutation-selection equilibrium can be expressed exactly in closed form for arbitrary fitness functions…

种群与进化 · 定量生物学 2023-02-28 Jenny M. Poulton , Lee Altenberg , Chris Watkins

We address the problem of identifying functional interactions among stochastic neurons with variable-length memory from their spiking activity. The neuronal network is modeled by a stochastic system of interacting point processes with…

应用统计 · 统计学 2025-07-01 Ricardo F. Ferreira , Matheus E. Pacola , Vitor G. Schiavone , Rodrigo F. O. Pena

Understanding specifically where a model focuses on within an image is critical for human interpretability of the decision-making process. Deep learning-based solutions are prone to learning coincidental correlations in training datasets,…

计算机视觉与模式识别 · 计算机科学 2024-10-22 Aidan Boyd , Mohamed Trabelsi , Huseyin Uzunalioglu , Dan Kushnir

The characterization of coordinated activity in neuronal populations has received renewed interest in the light of advancing experimental techniques which allow recordings from multiple units simultaneously. Across both in vitro and in vivo…

神经元与认知 · 定量生物学 2015-06-16 Feraz Azhar , William S. Anderson

Population dynamics deals with the collective phenomena of living organisms, and it has attracted much attention since it is expected to explain how not only living organisms but also human beings have been adapted to varying environments.…

统计力学 · 物理学 2019-04-23 Hideyuki Miyahara

Our knowledge of the organisation of the human brain at the population-level is yet to translate into power to predict functional differences at the individual-level, limiting clinical applications, and casting doubt on the generalisability…

Novel experimental techniques reveal the simultaneous activity of larger and larger numbers of neurons. As a result there is increasing interest in the structure of cooperative -- or correlated -- activity in neural populations, and in the…

神经元与认知 · 定量生物学 2015-05-30 James Trousdale , Yu Hu , Eric Shea-Brown , Krešimir Josić

Synaptic plasticity and neuron cross-talk are some of the important key mechanisms underlying formation of dynamic clusters of active neurons. The essence of this study is to model and decipher the mechanism of emergence of a task-specific…

神经元与认知 · 定量生物学 2021-08-03 Jasleen Gund , R. K. Brojen Singh

In the intricate architecture of the mammalian central nervous system, neurons form populations. Axonal bundles communicate between these clusters using spike trains. However, these neuron populations' precise encoding and operations have…

神经元与认知 · 定量生物学 2024-01-02 Martin N. P. Nilsson

Numerous studies have shown that neuronal responses are modulated by stimulus properties, and also by the state of the local network. However, little is known about how activity fluctuations of neuronal populations modulate the sensory…

神经元与认知 · 定量生物学 2017-11-07 Iñigo Arandia-Romero , Seiji Tanabe , Jan Drugowitsch , Adam Kohn , Rubén Moreno-Bote

Living neuronal networks in dissociated neuronal cultures are widely known for their ability to generate highly robust spatiotemporal activity patterns in various experimental conditions. These include neuronal avalanches satisfying the…

适应与自组织系统 · 物理学 2022-05-17 I. Y. Tyukin , D. Iudin , F. Iudin , T. Tyukina , V. Kazantsev , I. Mukhina , A. N. Gorban

Systems neuroscience relies on two complementary views of neural data, characterized by single neuron tuning curves and analysis of population activity. These two perspectives combine elegantly in neural latent variable models that…

We investigate the dynamics of a network consisting of an array of identical cortical units with nearest neighbor interactions under periodic arousal. Each unit consists of two interconnected populations of neurons tuned to a state in which…

神经元与认知 · 定量生物学 2019-02-12 Leandro M. Alonso

We propose a scalable semiparametric Bayesian model to capture dependencies among multiple neurons by detecting their co-firing (possibly with some lag time) patterns over time. After discretizing time so there is at most one spike at each…

应用统计 · 统计学 2015-06-22 Babak Shahbaba , Bo Zhou , Shiwei Lan , Hernando Ombao , David Moorman , Sam Behseta

Neural generative models can be used to learn complex probability distributions from data, to sample from them, and to produce probability density estimates. We propose a computational framework for developing neural generative models…

机器学习 · 计算机科学 2022-01-06 Alexander Ororbia , Daniel Kifer

The collective dynamics of neural populations are often characterized in terms of correlations in the spike activity of different neurons. Open questions surround the basic nature of these correlations. In particular, what leads to…

神经元与认知 · 定量生物学 2013-06-25 David Leen , Eric Shea-Brown

This paper aims to develop practical applications of the model for the highly technical measure-valued populations developed by the authors in \cite{FanEtal20}. We consider the problem of estimation of parameters in the general age and…

统计理论 · 数学 2025-06-30 Jie Yen Fan , Kais Hamza , Fima C. Klebaner , Ziwen Zhong

Coupling is a widely used technique in the theoretical study of interacting stochastic processes. In this paper I present an example demonstrating its usefulness also in the efficient computer simulation of such processes. I first describe…

种群与进化 · 定量生物学 2012-04-16 Ilmari Karonen

Humans and animals can recognize latent structures in their environment and apply this information to efficiently navigate the world. However, it remains unclear what aspects of neural activity contribute to these computational…

神经元与认知 · 定量生物学 2024-04-12 Albert J. Wakhloo , Will Slatton , SueYeon Chung

Much progress has been made in uncovering the computational capabilities of spiking neural networks. However, spiking neurons will always be more expensive to simulate compared to rate neurons because of the inherent disparity in time…

神经元与认知 · 定量生物学 2013-10-31 Michael A. Buice , Carson C. Chow