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To evaluate the nature of the neural code in the cerebral cortex, we have used a combination of theory and experiment to assess how information is represented in a realistic cortical population response. We have shown how a sensory stimulus…

神经元与认知 · 定量生物学 2008-03-28 L. C. Osborne , S. E. Palmer , S. G. Lisberger , W. Bialek

A main concern in cognitive neuroscience is to decode the overt neural spike train observations and infer latent representations under neural circuits. However, traditional methods entail strong prior on network structure and hardly meet…

神经元与认知 · 定量生物学 2019-11-22 Zhijie Chen , Junchi Yan , Longyuan Li , Xiaokang Yang

A key question in neuroscience is at which level functional meaning emerges from biophysical phenomena. In most vertebrate systems, precise functions are assigned at the level of neural populations, while single-neurons are deemed…

神经元与认知 · 定量生物学 2017-03-17 Wieland Brendel , Ralph Bourdoukan , Pietro Vertechi , Christian K. Machens , Sophie Denéve

The relationship between brain structure and function has been probed using a variety of approaches, but how the underlying structural connectivity of the human brain drives behavior is far from understood. To investigate the effect of…

神经元与认知 · 定量生物学 2018-11-15 Kanika Bansal , John D. Medaglia , Danielle S. Bassett , Jean M. Vettel , Sarah F. Muldoon

A body of recent work in modeling neural activity focuses on recovering low-dimensional latent features that capture the statistical structure of large-scale neural populations. Most such approaches have focused on linear generative models,…

神经元与认知 · 定量生物学 2016-10-26 Yuanjun Gao , Evan Archer , Liam Paninski , John P. Cunningham

We derive computationally tractable methods to select a small subset of experiment settings from a large pool of given design points. The primary focus is on linear regression models, while the technique extends to generalized linear models…

机器学习 · 统计学 2017-12-21 Yining Wang , Adams Wei Yu , Aarti Singh

A growing body of research indicates that structural plasticity mechanisms are crucial for learning and memory consolidation. Starting from a simple phenomenological model, we exploit a mean-field approach to develop a theoretical framework…

神经元与认知 · 定量生物学 2024-06-19 Gianmarco Tiddia , Luca Sergi , Bruno Golosio

The retina is a complex nervous system which encodes visual stimuli before higher order processing occurs in the visual cortex. In this study we evaluated whether information about the stimuli received by the retina can be retrieved from…

计算机视觉与模式识别 · 计算机科学 2017-01-18 Matteo Zanotto , Riccardo Volpi , Alessandro Maccione , Luca Berdondini , Diego Sona , Vittorio Murino

In exponentially proliferating populations of microbes, the population typically doubles at a rate less than the average doubling time of a single-cell due to variability at the single-cell level. It is known that the distribution of…

种群与进化 · 定量生物学 2020-07-29 Ethan Levien , Trevor GrandPre , Ariel Amir

We study a system of interacting renewal processes which is a model for neuronal activity. We show that the system possesses an exponentially large number (with respect to the number of neurons in the network) of limiting configurations of…

概率论 · 数学 2007-05-23 Marie Cottrell , Tatiana Turova

Neurons can display highly variable dynamics. While such variability presumably supports the wide range of behaviors generated by the organism, their gene expressions are relatively stable in the adult brain. This suggests that neuronal…

神经元与认知 · 定量生物学 2023-11-07 Lu Mi , Trung Le , Tianxing He , Eli Shlizerman , Uygar Sümbül

Population-based learning paradigms, including evolutionary strategies, Population-Based Training (PBT), and recent model-merging methods, combine fast within-model optimisation with slower population-level adaptation. Despite their…

机器学习 · 计算机科学 2026-03-26 Giacomo Borghi , Hyesung Im , Lorenzo Pareschi

The predictive power of neural networks often costs model interpretability. Several techniques have been developed for explaining model outputs in terms of input features; however, it is difficult to translate such interpretations into…

机器学习 · 计算机科学 2017-08-17 Benjamin J. Lengerich , Sandeep Konam , Eric P. Xing , Stephanie Rosenthal , Manuela Veloso

Maximum entropy methods provide a principled path connecting measurements of neural activity directly to statistical physics models, and this approach has been successful for populations of $N\sim 100$ neurons. As $N$ increases in new…

生物物理 · 物理学 2023-10-18 Christopher W. Lynn , Qiwei Yu , Rich Pang , William Bialek , Stephanie E. Palmer

Human trajectory forecasting in crowds, at its core, is a sequence prediction problem with specific challenges of capturing inter-sequence dependencies (social interactions) and consequently predicting socially-compliant multimodal…

计算机视觉与模式识别 · 计算机科学 2021-05-10 Parth Kothari , Brian Sifringer , Alexandre Alahi

We consider an excitatory population of subthreshold Izhikevich neurons which exhibit noise-induced firings. By varying the coupling strength $J$, we investigate population synchronization between the noise-induced firings which may be used…

神经元与认知 · 定量生物学 2014-03-06 Sang-Yoon Kim , Woochang Lim

Brain function results from communication between neurons connected by complex synaptic networks. Synapses are themselves highly complex and diverse signaling machines, containing protein products of hundreds of different genes, some in…

Foundation models are powerful yet often opaque in their decision-making. A topic of continued interest in both neuroscience and artificial intelligence is whether some neurons behave like grandmother cells, i.e., neurons that are…

机器学习 · 计算机科学 2026-01-08 Ricardo Knauer , Erik Rodner

There has lately been increased interest in describing complex systems not merely as single networks but rather as collections of networks that are coupled to one another. We introduce an analytically tractable model that enables one to…

物理与社会 · 物理学 2019-06-05 Juan Fernández-Gracia , Jukka-Pekka Onnela

Machine Learning techniques have been used to teach computer programs how to play games as complicated as Chess and Go. These were achieved using powerful tools such as Neural Networks and Parallel Computing on Supercomputers. In this…

种群与进化 · 定量生物学 2017-12-01 Pedro M. F. Pereira