相关论文: Image-Based Modeling of Blood Flow and Oxygen Tran…
We present a new method for modeling tissue perfusion on the capillary scale. The microvasculature is represented by a network of one-dimensional vessel segments embedded in the extra-vascular space. Vascular and extra-vascular space…
Modeling and simulating how oxygen supply shapes neuronal excitability is crucial for advancing the understanding of brain function in pathological scenarios, such as ischemia. This condition is caused by a reduced blood supply, leading to…
Flow of cerebrospinal fluid in perivascular spaces is a key mechanism underlying brain transport and clearance. In this paper, we present a mathematical and numerical formalism for reduced models of pulsatile viscous fluid flow in networks…
A vibrational model of transport properties of dense fluids assumes that solid-like oscillations of atoms around their temporary equilibrium positions dominate the dynamical picture. The temporary equilibrium positions of atoms do not form…
Complex fluids flow in complex ways in complex structures. Transport of water and various organic and inorganic molecules in the central nervous system are important in a wide range of biological and medical processes [C. Nicholson, and S.…
Metabolic substrates, such as oxygen and glucose, are rapidly delivered to the cell through filtration across microvessels walls. Modelling this important process is complicated by the coupling between flow and transport equations, which…
We report a new first-order phase transition preceding capillary condensation and corresponding to the discontinuous formation of a curved liquid meniscus. Using a mean-field microscopic approach based on the density functional theory we…
MRI measurements from a decade-old study of the physical properties of brain tissue observed a dynamic, pulsating fluid flow in the interstitial spaces of the brain attributed to the cardiac cycle. The effects of this cyclic flow pattern on…
The problem of two-phase flow in straight capillaries of polygonal cross section displays many of the dynamic characteristics of rapid interfacial motions associated with pore-scale displacements in porous media. Fluid inertia is known to…
Motivated by observations of saturation overshoot, this paper investigates numerical modeling of two-phase flow incorporating dynamic capillary pressure. The effects of the dynamic capillary coefficient, the infiltrating flux rate and the…
We propose a new phenomenological approach for describing the dynamics of wetting front propagation in porous media. Unlike traditional models, the proposed approach is based on dynamic nature of the relation between capillary pressure and…
Capillary-driven transport offers a simple, self-sustained alternative to externally pumped microfluidic systems, yet achieving precise control of such flows remains challenging. We experimentally and theoretically investigate capillary…
It has been postulated that the delivery of radiotherapy at ultra-high dose rates ("FLASH") reduces normal tissue toxicities by depleting them of oxygen. The fraction of normal tissue and cancer cells surviving radiotherapy depends on dose…
We apply the lubrication approximation to solve for the flow generated by a peristaltic traveling wave in a finite, planar channel, and examine the effect of channel length. Cerebrospinal fluid (CSF) is hypothesized to be peristaltically…
A computationally efficient method to calculate the capillary pressure-saturation relations of immiscible multiphase flow on two-dimensional pore morphologies is presented here. The method is an extension of the Pore Morphology Method that…
Capillary droplets form due to surface tension when two immiscible fluids are mixed. We describe the motion of gravity-driven capillary droplets flowing through narrow constrictions and obstacle arrays in both simulations and experiments.…
In the presented study, a numerical model which predicts the flow-induced collapse within the pharyngeal airway is validated using in vitro measurements. Theoretical simplifications were considered to limit the computation time. Systematic…
Scientists have long sought to understand how vascular networks supply blood and oxygen to cells throughout the body. Recent work focuses on principles that constrain how vessel size changes through branching generations from the aorta to…
Our understanding of both structure and dynamics of adsorbed liquids heavily relies on the capillary wave Hamiltonian, but a thorough test of this model is still lacking. Here we study the capillary wave fluctuations of a liquid film with…
This paper addresses the pulsating motion of cerebrospinal fluid in the aqueduct of Sylvius, a slender canal connecting the third and fourth ventricles of the brain. Specific attention is given to the relation between the instantaneous…