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We report a noise induced delay of bifurcation in a simple pulse-coupled neural circuit. We study the behavior of two neural oscillators, each individually governed by saddle-node dynamics, with reciprocal excitatory synaptic connections.…

生物物理 · 物理学 2007-05-23 Boris Gutkin , Tim Hely , Juergen Jost

Neural-network models of high-level brain functions such as memory recall and reasoning often rely on the presence of stochasticity. The majority of these models assumes that each neuron in the functional network is equipped with its own…

We discuss intrinsic noise effects in stochastic multiplicative-noise partial differential equations, which are qualitatively independent of the noise interpretation (Ito vs. Stratonovich), in particular in the context of noise-induced…

统计力学 · 物理学 2009-11-10 O. Carrillo , M. Ibanes , J. Garcia-Ojalvo , J. Casademunt , J. M. Sancho

Multicellular organisms exhibit a high degree of structural organization with specific cell types always occurring in characteristic locations. The conventional framework for describing the emergence of such consistent spatial patterns is…

组织与器官 · 定量生物学 2022-05-11 Chandrashekar Kuyyamudi , Shakti N. Menon , Sitabhra Sinha

Noise through its interaction with the nonlinearity of the living systems can give rise to counter-intuitive phenomena. In this paper we shortly review noise induced effects in different ecosystems, in which two populations compete for the…

种群与进化 · 定量生物学 2016-09-26 D. Valenti , A. Giuffrida , G. Denaro , N. Pizzolato , L. Curcio , B. Spagnolo , S. Mazzola , G. Basilone , A. Bonanno

Recent experiments have shown that stochastic effects exerted at the level of translation contribute a substantial portion of the variation in abundance of proteins expressed at moderate to high levels. This study analyzes translational…

亚细胞过程 · 定量生物学 2014-09-16 Sandip Datta , Brian Seed

Although stochastic optimization is central to modern machine learning, the precise mechanisms underlying its success, and in particular, the precise role of the stochasticity, still remain unclear. Modelling stochastic optimization…

机器学习 · 统计学 2020-06-12 Liam Hodgkinson , Michael W. Mahoney

Some systems cannot be predicted by classical theories and it is required the development of combined deterministic and stochastic theories that make used of noise for dynamical prediction. Noise is not always an interfering signal which…

适应与自组织系统 · 物理学 2019-05-14 Alexandra Pinto Castellanos

Biochemical reaction networks are subjected to large fluctuations attributable to small molecule numbers, yet underlie reliable biological functions. Most theoretical approaches describe them as purely deterministic or stochastic dynamical…

分子网络 · 定量生物学 2013-06-11 Jingkui Wang , Marc Lefranc , Quentin Thommen

Can noise be beneficial to machine-learning prediction of chaotic systems? Utilizing reservoir computers as a paradigm, we find that injecting noise to the training data can induce a stochastic resonance with significant benefits to both…

机器学习 · 计算机科学 2022-11-21 Zheng-Meng Zhai , Ling-Wei Kong , Ying-Cheng Lai

We consider a generic class of gene circuits affected by nonlinear extrinsic noise. To address this nonlinearity we introduce a general perturbative methodology based on assuming timescale separation between noise and genes dynamics, with…

分子网络 · 定量生物学 2023-05-10 Gerardo Aquino , Andrea Rocco

The effect of stochasticity, in the form of Gaussian white noise, in a predator-prey model with two distinct time-scales is presented. A supercritical singular Hopf bifurcation yields a Type II excitability in the deterministic model. We…

动力系统 · 数学 2017-07-20 Susmita Sadhu

We review the mathematical formalism underlying the modelling of stochasticity in biological systems. Beginning with a description of the system in terms of its basic constituents, we derive the mesoscopic equations governing the dynamics…

种群与进化 · 定量生物学 2012-11-05 Alan J. McKane , Tommaso Biancalani , Tim Rogers

In this paper we present a framework for investigating coloured noise in reaction-diffusion systems. We start by considering a deterministic reaction-diffusion equation and show how external forcing can cause temporally correlated or…

定量方法 · 定量生物学 2018-12-03 Michael F Adamer , Heather A Harrington , Eamonn A Gaffney , Thomas E Woolley

Intrinsic stochasticity can induce highly non-trivial effects on dynamical systems, including stochastic and coherence resonance, noise induced bistability, noise-induced oscillations, to name but a few. In this paper we revisit a mechanism…

无序系统与神经网络 · 物理学 2018-07-17 Serena di Santo , Pablo Villegas , Raffaella Burioni , Miguel A. Muñoz

The effect of intrinsic channel noise is investigated for the dynamic response of a neuronal cell with a delayed feedback loop. The loop is based on the so-called autapse phenomenon in which dendrites establish not only connections to…

生物物理 · 物理学 2014-12-22 Yunyun Li , Gerhard Schmid , Peter Hanggi , Lutz Schimansky-Geier

Inferring dynamical models from low-resolution temporal data continues to be a significant challenge in biophysics, especially within transcriptomics, where separating molecular programs from noise remains an important open problem. We…

机器学习 · 计算机科学 2023-10-05 Victor Chardès , Suryanarayana Maddu , Michael J. Shelley

How to induce differentiated cells into pluripotent cells has elicited researchers' interests for a long time since pluripotent stem cells are able to offer remarkable potential in numerous subfields of biological research. However, the…

分子网络 · 定量生物学 2014-12-09 Jiawei Yan , Pu Zheng , Xingjie Pan

We consider the general problem of describing the dynamics of subnetworks of larger biochemical reaction networks, e.g. protein interaction networks involving complex formation and dissociation reactions. We propose the use of model…

定量方法 · 定量生物学 2020-08-26 Barbara Bravi , Katy J. Rubin , Peter Sollich

The chemotaxis pathway in the bacterium Escherichia coli allows cells to detect changes in external ligand concentration (e.g. nutrients). The pathway regulates the flagellated rotary motors and hence the cells' swimming behaviour, steering…

细胞行为 · 定量生物学 2011-03-04 Diana Clausznitzer , Robert G Endres