相关论文: Homogenization Model for Aberrant Crypt Foci
Cancer results from a sequence of genetic and epigenetic changes which lead to a variety of abnormal phenotypes including increased proliferation and survival of somatic cells, and thus, to a selective advantage of pre-cancerous cells. The…
Tumorigenesis is an evolutionary process which involves a significant number of genomic rearrangements typically coupled with changes in the gene copy number profiles of numerous cells. Fluorescence in situ hybridization (FISH) is a…
The phenotypic equilibrium, i.e. heterogeneous population of cancer cells tending to a fixed equilibrium of phenotypic proportions, has received much attention in cancer biology very recently. In previous literature, some theoretical models…
Nuclei Identification and Counting is the most important morphological feature of cancers, especially in the colon. Many deep learning-based methods have been proposed to deal with this problem. In this work, we construct an extension of…
A topology preserving skeleton is a synthetic representation of an object that retains its topology and many of its significant morphological properties. The process of obtaining the skeleton, referred to as skeletonization or thinning, is…
Recently, there has been a resurgence of interest in rigorous algorithms for the inference of cancer progression from genomic data. The motivations are manifold: (i) growing NGS and single cell data from cancer patients, (ii) need for novel…
In this project, we used formalin-fixed paraffin-embedded (FFPE) tissue samples to measure thousands of spectra per tissue core with Fourier transform mid-infrared spectroscopy using an FT-IR imaging system. These cores varied between…
Circulating tumor cells (CTCs) are cancer cells found in the bloodstream that serve as biomarkers for early cancer detection, prognostication, and disease monitoring. However, CTC detection remains challenging due to low cell abundance and…
The aim of this paper is to investigate the asymptotic behavior of a biphase tumor fluid flow derived by 2-scale homogenisation techniques in recent works. This biphase fluid flow model accounts for the capillary wall permeability, and the…
Intra-tumour phenotypic heterogeneity limits accuracy of clinical diagnostics and hampers the efficiency of anti-cancer therapies. Dealing with this cellular heterogeneity requires adequate understanding of its sources, which is extremely…
Apart from regular, low-level stochastic variability, some AGN occasionally show exceptionally large changes in the luminosity, spectral shape, and/or X-ray absorption. The most notable are the changes of the spectral type when the source…
Heterogeneity is a hallmark of all cancers. Tumor heterogeneity is found at different levels -- interpatient, intrapatient, and intratumor heterogeneity. All of them pose challenges for clinical treatments. The latter two scenarios can also…
Assessment of the density of mitotic figures (MFs) in histologic tumor sections is an important prognostic marker for many tumor types, including breast cancer. Recently, it has been reported in multiple works that the quantity of MFs with…
Colonoscopy screening effectively identifies and removes polyps before they progress to colorectal cancer (CRC), but current follow-up guidelines rely primarily on histopathological features, overlooking other important CRC risk factors.…
Colorectal cancer is a deadly disease that has become increasingly prevalent in recent years. Early detection is crucial for saving lives, but traditional diagnostic methods such as colonoscopy and biopsy have limitations. Colonoscopy…
Imaging demonstrates that preclinical and human tumors are heterogeneous, i.e. a single tumor can exhibit multiple regions that behave differently during both normal development and also in response to treatment. The large variations…
Artificial Intelligence (AI) can potentially support histopathologists in the diagnosis of a broad spectrum of cancer types. In colorectal cancer (CRC), AI can alleviate the laborious task of characterization and reporting on resected…
Mining gene expression profiles has proven valuable for identifying signatures serving as surrogates of cancer phenotypes. However, the similarities of such signatures across different cancer types have not been strong enough to conclude…
Asymptotic homogenisation is used to systematically derive reduced-order macroscopic models of conductive behaviour in spirally-wound layered materials in which the layers have very different conductivities. The problem is motivated by the…
We present the properties of accretion disk corona (ADC) models, where the radiation field, the temperature, and the total opacity of the corona are determined self-consistently. We use a non-linear Monte Carlo code to perform the…