相关论文: Functional optimization of the arterial network

The structure of networks that provide optimal transport properties has been investigated in a variety of contexts. While many different formulations of this problem have been considered, it is recurrently found that optimal networks are…

Prediction of the blood flow characteristics is of utmost importance for understanding the behavior of the blood arterial network, especially in the presence of vascular diseases such as stenosis. Computational fluid dynamics (CFD) has…

We study network properties of networks evolving in time based on optimal transport principles. These evolve from a structure covering uniformly a continuous space towards an optimal design in terms of optimal transport theory. At…

Cytoskeletons are self-organized networks based on polymerized proteins: actin, tubulin, and driven by motor proteins, such as myosin, kinesin and dynein. Their positive Darwinian evolution enables them to approach optimized functionality…

Knowledge of the mechanical properties of the aorta is essential as important concerns regarding the treatment of aortic pathologies, such as atherosclerosis, aneurysms and dissections, are fundamentally mechanobiological. A comprehensive…

We propose a working hypothesis supported by numerical simulations that brain networks evolve based on the principle of the maximization of their internal information flow capacity. We find that synchronous behavior and capacity of…

Branching in vascular networks and in overall organismic form is one of the most common and ancient features of multicellular plants, fungi, and animals. By combining machine-learning techniques with new theory that relates vascular form to…

The link between atherosclerosis and blood flow-induced haemodynamic luminal shear stresses is well established. However, this understanding has not been translated into clinical practice because of the interdependent effects of the complex…

During pregnancy, oxygen diffuses from maternal to fetal blood through villous trees in the placenta. In this paper, we simulate blood flow and oxygen transfer in feto-placental capillaries by converting three-dimensional representations of…

Complex networks are ubiquitous in nature and play a role of paramount importance in many contexts. Internet and the cyberworld, which permeate our everyday life, are self-organized hierarchical graphs. Urban traffic flows on intricate road…

In this paper, we formulate a geometric theory of the mechanics of arterial growth. An artery is modeled as a finite-length thick shell that is made of an incompressible nonlinear anisotropic solid. An initial radially-symmetric…

The traditional view is that low shear stress of blood flow accelerates atherosclerosis. How does a low shear stress damage the vessel or aggravate atherosclerosis? It is a puzzling question. Furthermore, shear stress of veins is similar to…

As the discovery of non-Poissonian statistics of human mobility trajectories, more attention has been paid to understanding the role of these patterns in different dynamics. In this study, we first introduce the heterogeneous mobility of…

We introduce a methodology to study the possible matter flows of an ecosystem defined by observational biomass data and realistic biological constraints. The flows belong to a polyhedron in a multi dimensional space making statistical…

Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, affecting over 1% of the population. It is usually triggered by irregular electrical impulses that cause the atria to contract irregularly and…

We explore the possible role of elastic mismatch between epidermis and mesophyll as a driving force for the development of leaf venation. The current prevalent 'canalization' hypothesis for the formation of veins claims that the transport…

We discuss the physics of embolic stroke using a minimal model of emboli moving through the cerebral arteries. Our model of the blood flow network consists of a bifurcating tree, into which we introduce particles (emboli) that halt flow on…

Recent experimental and theoretical studies suggest that crystallization and glass-like solidification are useful analogies for understanding cell ordering in confluent biological tissues. It remains unexplored how cellular ordering…

Optimal transportation provides a means of lifting distances between points on a geometric domain to distances between signals over the domain, expressed as probability distributions. On a graph, transportation problems can be used to…

Elucidating the fitness measures optimized during the evolution of complex biological systems is a major challenge in evolutionary theory. We present experimental evidence and an analytical framework demonstrating how biochemical networks…