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The computer simulation of organ-scale biomechanistic models of cancer personalized via routinely collected clinical and imaging data enables to obtain patient-specific predictions of tumor growth and treatment response over the anatomy of…

The extended Fisher--Kolmogorov (EFK) equation has been used to describe some phenomena in physical, material and biology systems. In this paper, we propose a full-rank splitting scheme and a rank-adaptive splitting approach for this…

数值分析 · 数学 2024-03-20 Yong-Liang Zhao , Xian-Ming Gu

This work presents a structure-preserving, high-order, unconditionally stable numerical method for approximating the solution to the Fisher-Kolmogorov equation on polytopic meshes, with a particular focus on its application in simulating…

数值分析 · 数学 2025-09-25 Paola F. Antonietti , Mattia Corti , Sergio Gómez , Ilaria Perugia

In this work, we consider the discretization of some nonlinear Fokker-Planck-Kolmogorov equations. The scheme we propose preserves the non-negativity of the solution, conserves the mass and, as the discretization parameters tend to zero,…

数值分析 · 数学 2018-01-03 Elisabetta Carlini , Francisco J. Silva

This research introduces a new method for the transition from partial to ordinary differential equations that is based on the Kolmogorov superposition theorem. In this paper, we discuss the numerical implementation of the Kolmogorov theorem…

数值分析 · 数学 2021-11-02 Korney Tomashchuk

This paper deals with the question of how to most effectively conduct experiments in Partially Observed Markov Decision Processes so as to provide data that is most informative about a parameter of interest. Methods from Markov decision…

其他统计学 · 统计学 2018-01-31 Leifur Thorbergsson , Giles Hooker

We develop a new method to solve the Fokker-Planck or Kolmogorov's forward equation that governs the time evolution of the joint probability density function of a continuous-time stochastic nonlinear system. Numerical solution of this…

最优化与控制 · 数学 2018-11-16 Kenneth F. Caluya , Abhishek Halder

Spatiotemporal dynamics of populations may be described by the reaction-diffusion Fisher-Kolmogorov model. In this work we have proposed a new formulation for a control problem of aquatic plants in a temporal dynamics. The solution of this…

最优化与控制 · 数学 2020-06-22 Alexandre Molter , Fabio Silva Botelho

Whilst the partial differential equations that govern the dynamics of our world have been studied in great depth for centuries, solving them for complex, high-dimensional conditions and domains still presents an incredibly large…

机器学习 · 计算机科学 2023-03-07 Edward Small

Physical models in the form of partial differential equations serve as important priors for many under-constrained problems. One such application is tumor treatment planning, which relies on accurately estimating the spatial distribution of…

In this work, we investigate a fractional-order tumor growth model aimed at capturing memory effects and nonlocal temporal dynamics inherent to tumor evolution. The model is formulated using Caputo fractional derivatives and incorporates…

医学物理 · 物理学 2026-03-17 Karen Escutia , Carlos Islas , Pablo Padilla

The work presents a study of the non-linear mathematical model of tumor growth, proposed by Kolev and Zubik-Kowal (2011). The model is described by a system composed of four partial differential equations that represent the evolution of the…

组织与器官 · 定量生物学 2025-06-02 Jesika Maganin , Neyva Maria Lopes Romeiro , Eliandro Rodrigues Cirilo , Paulo Laerte Natti

The numerical solution of partial differential equations (PDEs) is challenging because of the need to resolve spatiotemporal features over wide length and timescales. Often, it is computationally intractable to resolve the finest features…

无序系统与神经网络 · 物理学 2019-08-22 Yohai Bar-Sinai , Stephan Hoyer , Jason Hickey , Michael P. Brenner

Many problems in science and engineering can be represented by a set of partial differential equations (PDEs) through mathematical modeling. Mechanism-based computation following PDEs has long been an essential paradigm for studying topics…

机器学习 · 计算机科学 2022-11-21 Shudong Huang , Wentao Feng , Chenwei Tang , Jiancheng Lv

In this work we consider a Fisher-Kolmogorov equation depending on two exponential functions of the spatial variables. We study this equation from the point of view of symmetry reductions in partial differential equations. Through…

偏微分方程分析 · 数学 2025-02-03 M. S. Bruzón , T. M. Garrido , E. Recio , R. de la Rosa

In this work, we present and analyse a system of coupled partial differential equations, which models tumour growth under the influence of subdiffusion, mechanical effects, nutrient supply, and chemotherapy. The subdiffusion of the system…

偏微分方程分析 · 数学 2021-10-08 Marvin Fritz , Christina Kuttler , Mabel L. Rajendran , Barbara Wohlmuth , Laura Scarabosio

Using the generalized Kolmogorov-Feller equation with long-range interaction, we obtain kinetic equations with fractional derivatives with respect to coordinates. The method of successive approximations with the averaging with respect to…

经典物理 · 物理学 2015-05-13 Vasily E. Tarasov , George M. Zaslavsky

We present an end-to-end framework to learn partial differential equations that brings together initial data production, selection of boundary conditions, and the use of physics-informed neural operators to solve partial differential…

计算物理 · 物理学 2023-08-21 Shawn G. Rosofsky , Hani Al Majed , E. A. Huerta

We derive novel algorithms for optimization problems constrained by partial differential equations describing multiscale particle dynamics, including non-local integral terms representing interactions between particles. In particular, we…

数值分析 · 数学 2021-09-09 Mildred Aduamoah , Benjamin D. Goddard , John W. Pearson , Jonna C. Roden

Partial differential equations are fundamental tools in mathematics,sciences and engineering. This book is mainly an exposition of the various algebraic techniques of solving partial differential equations for exact solutions developed by…

数学物理 · 物理学 2012-05-31 Xiaoping Xu
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