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When estimating a phylogeny from a multiple sequence alignment, researchers often assume the absence of recombination. However, if recombination is present, then tree estimation and all downstream analyses will be impacted, because…

统计方法学 · 统计学 2014-10-08 Peter B. Chi , Sujay Chattopadhyay , Philippe Lemey , Evgeni V. Sokurenko , Vladimir N. Minin

Genomes and genes diversify during evolution; however, it is unclear to what extent genes still retain the relationship among species. Model species for molecular phylogenetic studies include yeasts and viruses whose genomes were sequenced…

基因组学 · 定量生物学 2008-06-09 Yunfeng Shan , Xiu-Qing Li

Recently, much attention has been given to understanding recombination events along a chromosome in a variety of field. For instance, many population genetics problems are limited by the inaccuracy of inferred evolutionary histories of…

定量方法 · 定量生物学 2017-10-31 Jacqueline Kane , Joseph Rusinko , Katherine Thompson

We consider the problem of estimating the evolutionary history of a set of species (phylogeny or species tree) from several genes. It is known that the evolutionary history of individual genes (gene trees) might be topologically distinct…

种群与进化 · 定量生物学 2016-11-18 Gautam Dasarathy , Robert Nowak , Sebastien Roch

Phylogenetic reconstruction aims at finding plausible hypotheses of the evolutionary history of genes or species based on genomic sequence information. The distinction of orthologous genes (genes that having a common ancestry and diverged…

种群与进化 · 定量生物学 2016-02-29 Marc Hellmuth , Nicolas Wieseke

Phylogenetic networks are a type of directed acyclic graph that represent how a set $X$ of present-day species are descended from a common ancestor by processes of speciation and reticulate evolution. In the absence of reticulate evolution,…

组合数学 · 数学 2017-08-11 Andrew Francis , Charles Semple , Mike Steel

The pre-training paradigm fine-tunes the models trained on large-scale datasets to downstream tasks with enhanced performance. It transfers all knowledge to downstream tasks without discriminating which part is necessary or unnecessary,…

机器学习 · 计算机科学 2024-01-17 Fu Feng , Jing Wang , Xin Geng

Reticulate evolutionary processes result in phylogenetic histories that cannot be modeled using a tree topology. Here, we apply methods from topological data analysis to molecular sequence data with reticulations. Using a simple example, we…

定量方法 · 定量生物学 2015-11-05 Kevin Emmett , Raul Rabadan

The phenotype of any organism on earth is, in large part, the consequence of interplay between numerous gene products encoded in the genome, and such interplay between gene products affects the evolutionary fate of the genome itself through…

分子网络 · 定量生物学 2012-01-04 Pan-Jun Kim , Nathan D. Price

In a short article submitted to ArXiv [1], Maddamsetti et al. argue that the variation in the neutral mutation rate among genes in Escherichia coli that we recently reported [2] might be explained by horizontal gene transfer (HGT). To…

种群与进化 · 定量生物学 2012-11-08 Inigo Martincorena , Nicholas M. Luscombe

Phylogenetic networks extend phylogenetic trees to allow for modeling reticulate evolutionary processes such as hybridization. They take the shape of a rooted, directed, acyclic graph, and when parameterized with evolutionary parameters,…

种群与进化 · 定量生物学 2018-08-28 R. A. L. Elworth , H. A. Ogilvie , J. Zhu , L. Nakhleh

As whole genomes become widely available, maximum likelihood and Bayesian phylogenetic methods are demonstrating their limits in meeting the escalating computational demands. Conversely, distance-based phylogenetic methods are efficient,…

种群与进化 · 定量生物学 2025-02-07 Matthew J. Penn , Neil Scheidwasser , Mark P. Khurana , Christl A. Donnelly , David A. Duchêne , Samir Bhatt

The statistical estimation of phylogenies is always associated with uncertainty, and accommodating this uncertainty is an important component of modern phylogenetic comparative analysis. The birth-death polytomy resolver is a method of…

定量方法 · 定量生物学 2015-03-18 Daniel L. Rabosky

Phylogenetic networks are a generalization of phylogenetic trees that are used to represent non-tree-like evolutionary histories that arise in organisms such as plants and bacteria, or uncertainty in evolutionary histories. An…

种群与进化 · 定量生物学 2017-12-08 Andrew Francis , Katharina Huber , Vincent Moulton

Rooted phylogenetic networks are used to describe evolutionary histories that contain non-treelike evolutionary events such as hybridization and horizontal gene transfer. In some cases, such histories can be described by a phylogenetic…

种群与进化 · 定量生物学 2016-10-03 Laura Jetten , Leo van Iersel

A phylogenetic network is a directed acyclic graph that visualises an evolutionary history containing so-called reticulations such as recombinations, hybridisations or lateral gene transfers. Here we consider the construction of a simplest…

种群与进化 · 定量生物学 2008-05-16 Leo van Iersel , Steven Kelk

We consider a birth and death process in which death is due to both `natural death' and to competition between individuals, modelled as a quadratic function of population size. The resulting `logistic branching process' has been proposed as…

概率论 · 数学 2013-10-23 Alison Etheridge , Shidong Wang , Feng Yu

Gene trees are evolutionary trees representing the ancestry of genes sampled from multiple populations. Species trees represent populations of individuals -- each with many genes -- splitting into new populations or species. The coalescent…

种群与进化 · 定量生物学 2010-07-30 Elizabeth S. Allman , James H. Degnan , John A. Rhodes

A large class of phylogenetic networks can be obtained from trees by the addition of horizontal edges between the tree edges. These networks are called tree based networks. Reticulation-visible networks and child-sibling networks are all…

种群与进化 · 定量生物学 2015-09-09 Louxin Zhang

Given overlapping subsets of a set of taxa (e.g. species), and posterior distributions on phylogenetic tree topologies for each of these taxon sets, how can we infer a posterior distribution on phylogenetic tree topologies for the entire…

种群与进化 · 定量生物学 2021-04-23 Michael Karcher , Cheng Zhang , Frederick A Matsen