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We present a novel and simple method to numerically calculate Fisher Information Matrices for stochastic chemical kinetics models. The linear noise approximation is used to derive model equations and a likelihood function which leads to an…

应用统计 · 统计学 2015-05-27 Michal Komorowski , Maria J. Costa , David A. Rand , Michael Stumpf

Diffusion- and flow-based policies deliver state-of-the-art performance on long-horizon robotic manipulation and imitation learning tasks. However, these controllers employ a fixed inference budget at every control step, regardless of task…

机器人学 · 计算机科学 2025-11-27 Inkook Chun , Seungjae Lee , Michael S. Albergo , Saining Xie , Eric Vanden-Eijnden

In this work (Part I), we study three time-discretization procedures of the Dynamical Low-Rank Approximation (DLRA) of high-dimensional stochastic differential equations (SDEs). Specifically, we consider the Dynamically Orthogonal (DO)…

数值分析 · 数学 2026-01-30 Yoshihito Kazashi , Fabio Nobile , Fabio Zoccolan

Likelihood-based inference in stochastic non-linear dynamical systems, such as those found in chemical reaction networks and biological clock systems, is inherently complex and has largely been limited to small and unrealistically simple…

统计计算 · 统计学 2024-07-08 Ben Swallow , David A. Rand , Giorgos Minas

Sticky diffusion models a Markovian particle experiencing reflection and temporary adhesion phenomena at the boundary. Numerous numerical schemes exist for approximating stopped or reflected stochastic differential equations (SDEs), but…

数值分析 · 数学 2025-08-11 Akash Sharma

We investigate nonequilibrium steady-state dynamics in both continuous- and discrete-state stochastic processes. Our analysis focuses on planar diffusion dynamics and their coarse-grained approximations by discrete-state Markov chains.…

统计力学 · 物理学 2026-05-12 Ramón Nartallo-Kaluarachchi , Renaud Lambiotte , Alain Goriely

Many chemical reactions and molecular processes occur on timescales that are significantly longer than those accessible by direct simulation. One successful approach to estimating dynamical statistics for such processes is to use many short…

计算物理 · 物理学 2024-10-03 Chatipat Lorpaiboon , Spencer C. Guo , John Strahan , Jonathan Weare , Aaron R. Dinner

Noisy quantum simulation is challenging since one has to take into account the stochastic nature of the process. The dominating method for it is the density matrix approach. In this paper, we evaluate conditions for which this method is…

量子物理 · 物理学 2022-10-31 William Berquist , Danylo Lykov , Minzhao Liu , Yuri Alexeev

We study stochastic delay differential equations (SDDE) where the coefficients depend on the moving averages of the state process. As a first contribution, we provide sufficient conditions under which a linear path functional of the…

概率论 · 数学 2013-10-17 Salvatore Federico , Peter Tankov

The stochastic thermodynamics of a dilute, well-stirred mixture of chemically-reacting species is built on the stochastic trajectories of reaction events obtained from the Chemical Master Equation. However, when the molecular populations…

统计力学 · 物理学 2017-07-04 Jordan M. Horowitz

We consider the problem of estimating states and parameters in a model based on a system of coupled stochastic differential equations, based on noisy discrete-time data. Special attention is given to nonlinear dynamics and state-dependent…

统计方法学 · 统计学 2025-04-01 Uffe Høgsbro Thygesen , Kasper Kristensen

Derived from spiking neuron models via the diffusion approximation, the moment activation (MA) faithfully captures the nonlinear coupling of correlated neural variability. However, numerical evaluation of the MA faces significant challenges…

生物物理 · 物理学 2022-12-06 Yang Qi

This study introduces a training-free conditional diffusion model for learning unknown stochastic differential equations (SDEs) using data. The proposed approach addresses key challenges in computational efficiency and accuracy for modeling…

机器学习 · 计算机科学 2024-10-07 Yanfang Liu , Yuan Chen , Dongbin Xiu , Guannan Zhang

Stochastic approximation is a class of algorithms that update a vector iteratively, incrementally, and stochastically, including, e.g., stochastic gradient descent and temporal difference learning. One fundamental challenge in analyzing a…

机器学习 · 计算机科学 2025-11-06 Shuze Daniel Liu , Shuhang Chen , Shangtong Zhang

The diffusion approximation (DA) is widely used in the analysis of stochastic population dynamics, from population genetics to ecology and evolution. DA is an uncontrolled approximation that assumes the smoothness of the calculated quantity…

种群与进化 · 定量生物学 2021-01-04 Jayant Pande , Nadav M. Shnerb

The simulation of complex stochastic network dynamics arising, for instance, from models of coupled biomolecular processes remains computationally challenging. Often, the necessity to scan a models' dynamics over a large parameter space…

定量方法 · 定量生物学 2013-03-14 Tiago Ramalho , Marco Selig , Ulrich Gerland , Torsten A. Enßlin

Computational multi-scale methods capitalize on a large time-scale separation to efficiently simulate slow dynamics over long time intervals. For stochastic systems, one often aims at resolving the statistics of the slowest dynamics. This…

数值分析 · 数学 2021-05-14 Kristian Debrabant , Giovanni Samaey , Przemysław Zieliński

We present explicit methods for simulating diffusions whose generator is self-adjoint with respect to a known (but possibly not normalizable) density. These methods exploit this property and combine an optimized Runge-Kutta algorithm with a…

数值分析 · 数学 2014-06-27 Nawaf Bou-Rabee , Aleksandar Donev , Eric Vanden-Eijnden

Simulating stochastic differential equations (SDEs) in bounded domains, presents significant computational challenges due to particle exit phenomena, which requires accurate modeling of interior stochastic dynamics and boundary…

机器学习 · 统计学 2025-07-23 Minglei Yang , Yanfang Liu , Diego del-Castillo-Negrete , Yanzhao Cao , Guannan Zhang

We develop a new randomized iterative algorithm---stochastic dual ascent (SDA)---for finding the projection of a given vector onto the solution space of a linear system. The method is dual in nature: with the dual being a non-strongly…

数值分析 · 数学 2016-01-29 Robert Mansel Gower , Peter Richtarik