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In this paper, we investigate the fundamental limits on how the inter- spike time of a neuron oscillator can be perturbed by the application of a bounded external control input (a current stimulus) with zero net electric charge…

最优化与控制 · 数学 2012-11-20 Isuru S. Dasanayake , Jr-Shin Li

In this article, we study optimal control problems of spiking neurons whose dynamics are described by a phase model. We design minimum-power current stimuli (controls) that lead to targeted spiking times of neurons, where the cases with…

动力系统 · 数学 2010-11-18 Isuru Dasanayake , Jr-Shin Li

In this paper, we derive the minimum-energy periodic control that entrains an ensemble of structurally similar neural oscillators to a desired frequency. The state space representation of a nominal oscillator is reduced to a phase model by…

神经元与认知 · 定量生物学 2012-02-24 Anatoly Zlotnik , Jr-Shin Li

We use conductance based neuron models and the mathematical modeling of Optogenetics to define controlled neuron models and we address the minimal time control of these affine systems for the first spike from equilibrium. We apply tools of…

最优化与控制 · 数学 2016-07-20 Vincent Renault , Michèle Thieullen , Emmanuel Trélat

Synchronization of oscillations is a phenomenon prevalent in natural, social, and engineering systems. Controlling synchronization of oscillating systems is motivated by a wide range of applications from neurological treatment of…

最优化与控制 · 数学 2015-03-19 Jr-Shin Li , Isuru Dasanayake , Justin Ruths

We derive optimal periodic controls for entrainment of a self-driven oscillator to a desired frequency. The alternative objectives of minimizing power and maximizing frequency range of entrainment are considered. A state space…

混沌动力学 · 物理学 2011-09-27 Anatoly Zlotnik , Jr-Shin Li

Electrical brain stimulation relies on externally applied currents to modulate neural activity, but safety constraints require each stimulation cycle to be charge-balanced, enforcing a zero net injected charge. However, how such…

系统与控制 · 电气工程与系统科学 2025-12-09 Yuzhen Qin , Zonglin Liu , Marcel van Gerven

Periodic pulse train stimulation is generically used to study the function of the nervous system and to counteract disease-related neuronal activity, e.g., collective periodic neuronal oscillations. The efficient control of neuronal…

适应与自组织系统 · 物理学 2020-08-05 Kestutis Pyragas , Augustinas P. Fedaravičius , Tatjana Pyragienė

Excitation-inhibition (E-I) balance is ubiquitously observed in the cortex. Recent studies suggest an intriguing link between balance on fast timescales, tight balance, and efficient information coding with spikes. We further this…

神经元与认知 · 定量生物学 2021-05-04 Qianyi Li , Cengiz Pehlevan

Neurons communicate with downstream systems via sparse and incredibly brief electrical pulses, or spikes. Using these events, they control various targets such as neuromuscular units, neurosecretory systems, and other neurons in connected…

神经元与认知 · 定量生物学 2026-03-17 Paolo Agliati , André Urbano , Pablo Lanillos , Nasir Ahmad , Marcel van Gerven , Sander Keemink

This paper predicts the ability to externally control the firing times of a cortical neuron whose behavior follows the Izhikevich neuron model. The Izhikevich neuron model provides an efficient and biologically plausible method to track a…

神经元与认知 · 定量生物学 2018-09-06 Adam Noel , Shayan Monabbati , Dimitrios Makrakis , Andrew W. Eckford

We study a problem of designing ``robust'' external excitations for control and synchronization of an assembly of homotypic harmonic oscillators representing so-called theta neurons. The model of theta neurons (Theta model) captures, in…

This paper predicts the ability to externally control the firing times of a cortical neuron whose behavior follows the Izhikevich neuron model. The Izhikevich neuron model provides an efficient and biologically plausible method to track a…

神经元与认知 · 定量生物学 2020-04-24 Adam Noel , Shayan Monabbati , Dimitrios Makrakis , Andrew W. Eckford

Dynamical balance of excitation and inhibition is usually invoked to explain the irregular low firing activity observed in the cortex. We propose a robust nonlinear balancing mechanism for a random network of spiking neurons, which works…

无序系统与神经网络 · 物理学 2025-05-29 Antonio Politi , Alessandro Torcini

We investigate the optimal charging processes for several models of quantum batteries, finding how to maximize the energy stored in a given battery with a finite-time modulation of a set of external fields. We approach the problem using…

Precise control of signal propagation in modular neural networks represents a fundamental challenge in computational neuroscience. We establish a framework for identifying optimal control nodes that maximize stimulus transmission between…

神经元与认知 · 定量生物学 2025-08-18 Bulat Batuev , Arsenii Onuchin , Sergey Sukhov

Motivated by deep brain stimulation treatment of neural disorders such as Parkinson's disease, it has been proposed that desynchronization of neural oscillators can be achieved by maximizing the Lyapunov exponent of the phase difference…

最优化与控制 · 数学 2025-09-25 Jeff Moehlis , Michael Zimet , Faranak Rajabi

The excitability property of spiking neurons describes their capability to output an action potential as a real-time response to an input synaptic excitation current and is central to the event-based neuromorphic computing paradigm. The…

统计力学 · 物理学 2025-11-18 Léopold Van Brandt , Grégoire Brandsteert , Denis Flandre

In this paper we deal with a feedback control design for the action potential of a neuronal membrane in relation with the non-linear dynamics of the Hodgkin-Huxley mathematical model. More exactly, by using an external current as a control…

最优化与控制 · 数学 2020-04-22 Cecilia Cavaterra , Denis Enachescu , Gabriela Marinoschi

This article investigates the emergence of phase synchronization in a network of randomly connected neurons by chemical synapses. The study uses the classic Hodgkin-Huxley model to simulate the neuronal dynamics under the action of a train…

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