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Beyond prompt irradiation, Cs-137 is likely to be the most biologically important agent released in many accidental (or malicious) radiation exposure scenarios. Cs-137 either can enter the food chain or be consumed or if present in the…

Robotic telesurgical systems are one of the most complex medical cyber-physical systems on the market, and have been used in over 1.75 million procedures during the last decade. Despite significant improvements in design of robotic surgical…

Adaptive radiotherapy is a growing field of study in cancer treatment due to it's objective in sparing healthy tissue. The standard of care in several institutions includes longitudinal cone-beam computed tomography (CBCT) acquisitions to…

计算机视觉与模式识别 · 计算机科学 2023-03-08 William Trung Le , Chulmin Bang , Philippine Cordelle , Daniel Markel , Phuc Felix Nguyen-Tan , Houda Bahig , Samuel Kadoury

Quantitative extraction of high-dimensional mineable data from medical images is a process known as radiomics. Radiomics is foreseen as an essential prognostic tool for cancer risk assessment and the quantification of intratumoural…

The problem of detecting a nuclear weapon smuggled in an ocean-going cargo container has not been solved, and the detonation of such a device in a large city could produce casualties and property damage exceeding those of September 11, 2001…

物理与社会 · 物理学 2012-05-22 J. I. Katz , G. S. Blanpied , K. N. Borozdin , C. Morris

Radioactive ion beams (RIB) are a key focus of current research in nuclear physics. Already long ago it was proposed that they could have applications in cancer therapy. In fact, while charged particle therapy is potentially the most…

Cardiotoxicity induced by cancer treatment has become a major clinical concern, affecting the long-term survival and quality of life of cancer patients. Effective clinical decision-making, including the detection of cancer treatment-induced…

人机交互 · 计算机科学 2024-08-08 Siyi Wu , Weidan Cao , Shihan Fu , Bingsheng Yao , Ziqi Yang , Changchang Yin , Varun Mishra , Daniel Addison , Ping Zhang , Dakuo Wang

We evaluated the viability of using a Large Language Model (LLM) to extract patient-specific specific toxicity and progression outcomes from unstructured radiology reports. We retrospectively extracted 160 follow-up CT and PET/CT electronic…

医学物理 · 物理学 2026-03-02 Justin Pijanowski , Yakout Mezgueldi , Alan Lee , Drew Moghanaki , Ricky R. Savjani , James Lamb

In this work, we focus on the analytical and numerical study of a mathematical model for brain tumors with radiotherapy influence. Under certain assumptions on the given data in the model, we prove existence and uniqueness of a weak…

偏微分方程分析 · 数学 2024-09-27 Marina Chugunova , Hangjie Ji , Roman Taranets , Nataliya Vasylyeva

In oncology, treating cancer with a beam of photons is a well established therapeutic technique, developed over 100 years, and today over 50% of cancer patients will undergo traditional X-ray radiotherapy. However, ionizing radiation…

医学物理 · 物理学 2016-02-08 Mersini Makropoulou

To improve the quality of cancer treatment with protons, a translation of X-ray Computed Tomography (CT) images into a map of the proton stopping powers needs to be more accurate. Proton stopping powers determined from CT images have…

Recent developments for the delivery of proton and ion beam therapy have been significant, and a number of technological solutions now exist for the creation and utilisation of these particles for the treatment of cancer. In this paper we…

加速器物理 · 物理学 2015-06-17 Hywel Owen , David Holder , Jose Alonso , Ranald MacKay

Diffusing alpha-emitters Radiation Therapy (Alpha DaRT) enables the use of alpha particles for the treatment of solid tumors. It employs interstitial sources carrying a few uCi of Ra-224, designed to release its short-lived progeny, which…

医学物理 · 物理学 2023-11-16 Lior Epstein , Guy Heger , Arindam Roy , Israel Gannot , Itzhak Kelson , Lior Arazi

Radiomics is a nascent field in quantitative imaging that uses advanced algorithms and considerable computing power to describe tumor phenotypes, monitor treatment response, and assess normal tissue toxicity quantifiably. Remarkable…

医学物理 · 物理学 2019-11-26 Jiwoong Jeong , Arif Ali , Tian Liu , Hui Mao , Walter J. Curran , Xiaofeng Yang

This paper deals with the classic radiotherapy dose fractionation problem for cancer tumors concerning the following goals: a) To maximize the effect of radiation on the tumor, restricting the effect produced to the organs at risk (healing…

最优化与控制 · 数学 2021-02-17 Luis Alberto Fernández , Lucía Fernández

Boron Neutron Capture Therapy (BNCT) is a neutron radiotherapy used to treat tumours cells previously doping with Boron-10. This therapy requires an epithermal neutron beam for the treatment of deep tumours and a thermal beam for shallow…

仪器与探测器 · 物理学 2021-06-02 M. Macías , B. Fernández , J. Praena

In biomedical research and the practice of cancer therapy, gold nanoparticles have been used to visualize malignant tumors, as the heated bodies for hyperthermia of cancer cells, as drug carriers to deliver drugs to a cancer cell, but, to…

Dose distribution (depthwise and laterally) to organs outside the radiotherapy treatment field can be significant and therefore is of clinical interest from the radiation protection point of view. In the present work, measurements were…

医学物理 · 物理学 2012-03-19 Md. Farid Ahmed , S. Roy , G. U. Ahmed , F. K. Miah

External beam X-ray therapy (XRT) and proton therapy (PT) are effective and widely accepted forms of treatment for many types of cancer. However, the procedures require extensive computerized planning. Current planning systems for both XRT…

图形学 · 计算机科学 2018-11-30 Felix G. Hamza-Lup , Shane Farrar , Erik Leon

Rapid technological advances in radiation therapy have significantly improved dose delivery and tumor control for head and neck cancers. However, treatment-related toxicities caused by high-dose exposure to critical structures remain a…