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Consider the problem of simultaneously testing null hypotheses H_1,...,H_s. The usual approach to dealing with the multiplicity problem is to restrict attention to procedures that control the familywise error rate (FWER), the probability of…

统计理论 · 数学 2007-06-13 E. L. Lehmann , Joseph P. Romano

Consider the multiple testing problem of testing null hypotheses $H_1,...,H_s$. A classical approach to dealing with the multiplicity problem is to restrict attention to procedures that control the familywise error rate ($\mathit{FWER}$),…

统计理论 · 数学 2007-06-13 Joseph P. Romano , Azeem M. Shaikh

Consider the problem of testing multiple null hypotheses. A classical approach to dealing with the multiplicity problem is to restrict attention to procedures that control the familywise error rate ($FWER$), the probability of even one…

统计理论 · 数学 2007-06-13 Joseph P. Romano , Azeem M. Shaikh

When simultaneously testing multiple hypotheses, the usual approach in the context of confirmatory clinical trials is to control the familywise error rate (FWER), which bounds the probability of making at least one false rejection. In many…

统计方法学 · 统计学 2021-05-20 David S. Robertson , James M. S. Wason , Frank Bretz

A classical approach for dealing with the multiple testing problem is to restrict attention to procedures that control the familywise error rate (FWER), the probability of at least one false rejection. In many applications, one might be…

统计理论 · 数学 2008-10-29 Wenge Guo , M. Bhaskara Rao

In many applications of multiple hypothesis testing where more than one false rejection can be tolerated, procedures controlling error rates measuring at least $k$ false rejections, instead of at least one, for some fixed $k\ge 1$ can…

统计理论 · 数学 2008-12-18 Sanat K. Sarkar

This paper presents a survey on some recent advances for the type I error rate control in multiple testing methodology. We consider the problem of controlling the $k$-family-wise error rate (kFWER, probability to make $k$ false discoveries…

统计方法学 · 统计学 2011-03-15 Etienne Roquain

In a multiple testing problem where one is willing to tolerate a few false rejections, procedure controlling the familywise error rate (FWER) can potentially be improved in terms of its ability to detect false null hypotheses by…

统计理论 · 数学 2008-12-18 Sanat K. Sarkar

The concept of $k$-FWER has received much attention lately as an appropriate error rate for multiple testing when one seeks to control at least $k$ false rejections, for some fixed $k\ge 1$. A less conservative notion, the $k$-FDR, has been…

统计理论 · 数学 2009-06-18 Sanat K. Sarkar , Wenge Guo

Improved procedures, in terms of smaller missed discovery rates (MDR), for performing multiple hypotheses testing with weak and strong control of the family-wise error rate (FWER) or the false discovery rate (FDR) are developed and studied.…

统计理论 · 数学 2011-03-10 Edsel A. Peña , Joshua D. Habiger , Wensong Wu

A resurgence of interest in multiple hypothesis testing has occurred in the last decade. Motivated by studies in genomics, microarrays, DNA sequencing, drug screening, clinical trials, bioassays, education and psychology, statisticians have…

统计理论 · 数学 2007-06-13 Arthur Cohen , Harold B. Sackrowitz

We present a unifying approach to multiple testing procedures for sequential (or streaming) data by giving sufficient conditions for a sequential multiple testing procedure to control the familywise error rate (FWER), extending to the…

统计方法学 · 统计学 2015-02-25 Jay Bartroff , Jinlin Song

When many (m) null hypotheses are tested with a single dataset, the control of the number of false rejections is often the principal consideration. Two popular controlling rates are the probability of making at least one false discovery…

统计方法学 · 统计学 2013-07-11 Djalel Eddine Meskaldji , Jean-Philippe Thiran , Stephan Morgenthaler

Biological research often involves testing a growing number of null hypotheses as new data is accumulated over time. We study the problem of online control of the familywise error rate (FWER), that is testing an apriori unbounded sequence…

统计方法学 · 统计学 2020-03-10 Jinjin Tian , Aaditya Ramdas

In this paper, we consider the problem of simultaneously testing many two-sided hypotheses when rejections of null hypotheses are accompanied by claims of the direction of the alternative. The fundamental goal is to construct methods that…

统计理论 · 数学 2017-03-21 Anjana Grandhi , Wenge Guo , Joseph P. Romano

The probability of false discovery proportion (FDP) exceeding $\gamma\in[0,1)$, defined as $\gamma$-FDP, has received much attention as a measure of false discoveries in multiple testing. Although this measure has received acceptance due to…

统计理论 · 数学 2014-06-03 Wenge Guo , Li He , Sanat K. Sarkar

Modern biomedical research frequently involves testing multiple related hypotheses, while maintaining control over a suitable error rate. In many applications the false discovery rate (FDR), which is the expected proportion of false…

统计方法学 · 统计学 2018-09-27 David S. Robertson , James M. S. Wason

The $\gamma$-FDP and $k$-FWER multiple testing error metrics, which are tail probabilities of the respective error statistics, have become popular recently as less-stringent alternatives to the FDR and FWER. We propose general and flexible…

统计方法学 · 统计学 2016-12-20 Jay Bartroff

The introduction of the false discovery rate (FDR) by Benjamini and Hochberg has spurred a great interest in developing methodologies to control the FDR in various settings. The majority of existing approaches, however, address the FDR…

统计方法学 · 统计学 2016-06-09 Kasra Alishahi , Ahmad Reza Ehyaei , Ali Shojaie

Despite the popularity of the false discovery rate (FDR) as an error control metric for large-scale multiple testing, its close Bayesian counterpart the local false discovery rate (lfdr), defined as the posterior probability that a…

统计方法学 · 统计学 2023-09-22 Jake A. Soloff , Daniel Xiang , William Fithian
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