相关论文: Converting genetic network oscillations into somit…

During tissue development, patterns of gene expression determine the spatial arrangement of cell types. In many cases, gradients of secreted signaling molecules - morphogens - guide this process. The continuous positional information…

Nano structures, namely, nano rings and nanoparticles, comprising two dimensional, crystalline gold atomic discs were produced on a sapphire substrate. Nano rings revealed several remarkable properties, namely, an apparent spatial…

We study a generic model for the polarisation and motility of self-propelled soft objects, biological cells or biomimetic systems, interacting with a viscous substrate. The active forces generated by the cell on the substrate are modelled…

DNA methylation is a primary layer of epigenetic modification that plays a pivotal role in the regulation of development, aging, and cancer. The concurrent activity of opposing enzymes that mediate DNA methylation and demethylation gives…

Oscillations lie at the core of many biological processes, from the cell cycle, to circadian oscillations and developmental processes. Time-keeping mechanisms are essential to enable organisms to adapt to varying conditions in environmental…

Finding the origin of slow and infra-slow oscillations could reveal or explain brain mechanisms in health and disease. Here, we present a biophysically constrained computational model of a neural network where the inclusion of astrocytes…

Animals chain movements into long-lived motor strategies, exhibiting variability across scales that reflects the interplay between internal states and environmental cues. To reveal structure in such variability, we build Markov models of…

Bone remodeling is a complex process involving cell-cell interactions, biochemical signaling and mechanical stimuli. Early models of the biological aspects of remodeling were non-spatial and focused on the local dynamics at a fixed location…

Oscillatory dynamics of complex networks has recently attracted great attention. In this paper we study pattern formation in oscillatory complex networks consisting of excitable nodes. We find that there exist a few center nodes and small…

In neurosciences, the brain processes information via the firing patterns of connected neurons operating across a spectrum of frequencies. To better understand the effects of these frequencies in the neuron dynamics, we have simulated a…

We propose a spatially continuous and temporally discrete model for pattern formation in vertically vibrated granular layers. The grain transfer and the grain mobility transitions are introduced qualitatively, but explicitly. This model…

Many biological tissues are viscoelastic, behaving as elastic solids on short timescales and fluids on long timescales. This collective mechanical behavior enables and helps to guide pattern formation and tissue layering. Here we…

In this paper we propose a "discrete in continuous" mathematical model for the morphogenesis of the posterior lateral line system in zebrafishes. Our model follows closely the results obtained in recent biological experiments. We rely on a…

Fluid mechanics plays a vital role in early vertebrate embryo development, an example being the establishment of left-right asymmetry. Following the dorsal-ventral and anterior-posterior axes, the left-right axis is the last to be…

Spatiotemporal patterns are common in biological systems. For electrically-coupled cells previous studies of pattern formation have mainly used external forcing as the main bifurcation parameter. The purpose of this paper is to show that…

Neurosurgery interventions involve complex tracking systems because a tissue deformation takesplace. The neuronavigation system relies only on preoperative images. In order to overcome the soft tissue deformations and guarantee the accuracy…

Mathematical models of spatial population dynamics typically focus on the interplay between dispersal events and birth/death processes. However, for many animal communities, significant arrangement in space can occur on shorter timescales,…

We discovered generalized structures, named astrocytes due to their shape, that constitute a defined region characterizing regular behavior within the parameter plane (PP) of dynamical systems (DSs). Morphologically, they are characterized…

Spatio-temporal pattern formation over the square and rectangular domain has received significant attention from researchers. A wide range of stationary and non-stationary patterns produced by two interacting populations is abundant in the…

The development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems that display oscillations in protein concentration. Here we review the different mechanisms which can produce…