医学物理
X-ray microtomography is a powerful non-destructive technique allowing 3D virtual histology of resected human tissue. The achievable imaging field-of-view, is however limited by the fixed number of detector elements, enforcing the…
Background: Computed Tomography Angiography (CTA) is crucial for cerebrovascular disease diagnosis. Dynamic CTA is a type of imaging that captures temporal information about the We aim to develop and evaluate two segmentation techniques to…
Quantitative angiography (QA) in two dimensions has been instrumental in assessing neurovascular contrast flow patterns, aiding disease severity and treatment outcome evaluations. However, QA requires high spatio-temporal resolution,…
Intracortical US imaging extends B-mode imaging into bone using a dedicated image reconstruction algorithm that corrects for refraction at the bone-soft tissue interfaces. It has shown promising results in a few healthy, predominantly young…
Modeling the absorbed dose during X-ray imaging is essential for optimizing radiation exposure. Monte Carlo simulations (MCS) are the gold standard for precise 3D dose estimation but require significant computation time. Deep learning…
Spatially discordant alternans (SDA) play a crucial role in cardiac arrhythmogenesis by creating steep repolarization gradients facilitating conduction block and reentry. While traditionally studied using electrical indicators, this work…
Quantifying the myelin sheath radius of myelinated axons in vivo is important for understanding, diagnosing, and monitoring various neurological disorders. Despite advancements in diffusion MRI (dMRI) microstructure techniques, there are…
Objectives: Permissible limits have been established by international guidelines and standards for human protection to electromagnetic field exposure to prevent adverse health effects stemming from electrostimulation in the most sensitive…
The primary objective of helmet design continues to be the prevention of traumatic brain injuries. Yet, achieving an optimal user experience, including aspects such as fit, thermal comfort, breathability, waterproofing, and reusability, is…
With the emergence of CNT (Carbon nanotube), static and instant CT scanning becomes possible. By transforming the traditionally rotated thermal source into a static ring array source composed of multiple CNTs, the imaging system can achieve…
Ultrahigh-field MRI, such as those operating at 7 Tesla, enhances diagnostic capabilities but also presents unique challenges, including the need for advanced RF coil designs to achieve an optimal signal-to-noise ratio and transmit…
This study introduces an advanced multiphysics and multiscale modeling approach to investigate intestinal motility. We propose a generalized electromechanical framework that incorporates contact mechanics, enabling the development of a…
There is an unmet clinical need for developing novel methods to complement and replace the current radiation-emitting imaging-based methods for the detection of loose pedicle screws as a complication after spinal fusion surgery which fail…
Objective: Long-axial field-of-view (LAFOV) positron emission tomography (PET) systems allow higher sensitivity, with an increased number of detected lines of response induced by a larger angle of acceptance. However, this extended angle…
Democratizing biomarker testing at the point-of-care requires innovations that match laboratory-grade sensitivity and precision in an accessible format. Here, we demonstrate high-sensitivity detection of cardiac troponin I (cTnI) through…
Transcranial low-intensity focused ultrasound can deliver energy to the brain in a minimally invasive manner for neuromodulation applications. However, continuous sonication through the skull introduces significant wave interactions,…
Hyperspectral unmixing aims at decomposing a given signal into its spectral signatures and its associated fractional abundances. To improve the accuracy of this decomposition, algorithms have included different assumptions depending on the…
Diffusion models demonstrate state-of-the-art performance on image generation, and are gaining traction for sparse medical image reconstruction tasks. However, compared to classical reconstruction algorithms relying on simple analytical…
Research on ultra-high dose rate (UHDR) radiation therapy has indicated its potential to spare normal tissue while maintaining equivalent tumor control compared to conventional treatments. First clinical trials are underway. The randomized…
Developing new methods for predicting electromagnetic instabilities in cardiac activity is of primary importance. However, we still need a comprehensive view of the heart's magnetic activity at the tissue scale. To fill this gap, we present…