医学物理
Purpose: Provide a closed-form solution to the sinusoidal coil sensitivity model proposed by Kern et al. Solution allows for the precise computations of varied, simulated bias fields which can be directly applied onto raw intensity…
Pathological diagnosis relies on the visual inspection of histologically stained thin tissue specimens, where different types of stains are applied to bring contrast to and highlight various desired histological features. However, the…
Photoacoustic Remote Sensing (PARS) microscopy is an emerging label-free optical absorption imaging modality. PARS operates by capturing nanosecond-scale optical perturbations generated by photoacoustic pressures. These time-domain (TD)…
Proton computed tomography (CT) is similar to x-ray CT but relies on protons rather than photons to form an image. In its most common operation mode, the measured quantity is the amount of energy that a proton has lost while traversing the…
Photoacoustic imaging (PAI) is a promising approach to realize in vivo transcranial cerebral vascular imaging. However, the strong attenuation and distortion of the photoacoustic wave caused by the thick porous skull greatly affect the…
Intra-frame motion blurring, as a major challenge in free-breathing dynamic MRI, can be reduced if high temporal resolution can be achieved. To address this challenge, this work proposes a highly-accelerated 4D (3D+time) real-time MRI…
Purpose: The set of linear attenuation coefficients that belong to materials in the human body is commonly assumed to be spanned by two basis functions in the range of clinical x-ray energies, even though there is evidence that the…
Segmentation of lymphoma lesions is challenging due to their varied sizes and locations in whole-body PET scans. This work presents a fully-automated segmentation technique using a multi-center dataset of diffuse large B-cell lymphoma…
Purpose: To evaluate a proposed method to reconstruct CT numbers that accurately mimic conventional CT numbers from spectral CT data, as would have been produced by a conventional system without effects of beam hardening. Approach: We…
Objective: Soft-tissue sarcoma spreads preferentially along muscle fibers. We explore the utility of deriving muscle fiber orientations from diffusion tensor MRI (DT-MRI) for defining the boundary of the clinical target volume in muscle…
Purpose: In this study, we present the creation of an anthropomorphic, head and neck, nuclear medicine phantom and its characterization for the validation of a Monte Carlo, SPECT image based, Iodine-131 RPT dosimetry workflow. Methods: 3D…
Photon-counting CT (PCCT) offers improved diagnostic performance through better spatial and energy resolution, but developing high-quality image reconstruction methods that can deal with these large datasets is challenging. Model-based…
The quality of the inverse approach in electroencephalography (EEG) source analysis is - among other things - depending on the accuracy of the forward modeling approach, i.e., the simulation of the electric potential for a known dipole…
Fast Fourier Transform (FFT) relies on the HRV frequency-domain analysis techniques. It requires re-sampling of the inherently unevenly sampled heartbeat time-series (RR tachogram) to produce an evenly sampled time series of the heartbeat.…
Electrocorticography (ECoG) or intracranial electroencephalography (iEEG) monitors electric potential directly on the surface of the brain and can be used to inform treatment planning for epilepsy surgery when paired with numerical…
Description of purpose: Contrast-enhanced spectral mammography can be used to guide needle biopsies. However, in vertical approach the compressed breast is deformed generating a so-called bump in the paddle aperture, which may interfere…
The formation of amyloid plaques in the cortical and hippocampal brain regions caused by abnormal deposition of extracellular amyloid \b{eta}-protein (A\b{eta}) is a characteristic pathological hallmark of early Alzheimer's disease (AD),…
We apply the superiorization methodology to the intensity-modulated radiation therapy (IMRT) treatment planning problem. In superiorization, linear voxel dose inequality constraints are the fundamental modeling tool within which a…
The paper proposes a novel medical device based on a 9 dof IMU to help health professionals performing more precisely the electrode placement task in EEG exams. The tool precisely tells the operator if the 10-20 electrode placement system…
Spectral computed tomography (CT) is an emerging technology, that generates a multienergy attenuation map for the interior of an object and extends the traditional image volume into a 4D form. Compared with traditional CT based on…