Stability Threshold as a Selection Principle for Protein Design
软凝聚态物质
2009-10-30 v1 q-bio
摘要
The sensitivity of the native states of protein-like heteropolymers to mutations modelled as perturbations in the interaction potential between amino acids is studied. The stability threshold against mutations is shown to be zero for random heteropolymers on a lattice in two dimensions, whereas a design procedure modelling evolution produces a non-zero threshold. We introduce an evolution-like protein design procedure based on an optimization of the stability threshold that is shown to naturally ensure thermodynamic stability as well.
引用
@article{arxiv.cond-mat/9704167,
title = {Stability Threshold as a Selection Principle for Protein Design},
author = {Michele Vendruscolo and Amos Maritan and Jayanth R. Banavar},
journal= {arXiv preprint arXiv:cond-mat/9704167},
year = {2009}
}
备注
4 pages, RevTex, 4 figures included, to appear on Phys. Rev. Lett