DNA sequence from the unzipping force? : one mutation problem
统计力学
2009-11-07 v2 软凝聚态物质
q-bio
摘要
The possibility of detecting mutations in a DNA from force measurements (as a first step towards sequence analysis) is discussed theoretically based on exact calculations. The force signal is associated with the domain wall separating the zipped from the unzipped regions. We propose a comparison method (``differential force microscope'') to detect mutations. Two lattice models are treated as specific examples.
关键词
引用
@article{arxiv.cond-mat/0106110,
title = {DNA sequence from the unzipping force? : one mutation problem},
author = {Somendra M. Bhattacharjee and D. Marenduzzo},
journal= {arXiv preprint arXiv:cond-mat/0106110},
year = {2009}
}
备注
11 pages, 4 figures. Revised version with minor changes. Paragraph with discussion on experiments added. Accepted for publication in J. Phys. A as a Letter to the Editor