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Complexes of physically interacting proteins constitute fundamental functional units responsible for driving biological processes within cells. A faithful reconstruction of the entire set of complexes is therefore essential to understand…

分子网络 · 定量生物学 2015-05-21 Sriganesh Srihari , Chern Han Yong , Ashwini Patil , Limsoon Wong

The identification of essential proteins can help in understanding the minimum requirements for cell survival and development. Network-based centrality approaches are commonly used to identify essential proteins from protein-protein…

计算工程、金融与科学 · 计算机科学 2023-11-13 Li Pan , Haoyue Wang , Jing Sun , Bin Li , Bo Yang , Wenbin Li

Summary: The ModuLand plug-in provides Cytoscape users an algorithm for determining extensively overlapping network modules. Moreover, it identifies several hierarchical layers of modules, where meta-nodes of the higher hierarchical layer…

Compound graphs are networks in which vertices can be grouped into larger subsets, with these subsets capable of further grouping, resulting in a nesting that can be many levels deep. In several applications, including biological workflows,…

人机交互 · 计算机科学 2024-08-09 Chang Han , Justin Lieffers , Clayton Morrison , Katherine E. Isaacs

Many networks in real-life typically contain parts in which some nodes are more highly connected to each other than the other nodes of the network. The collection of such nodes are usually called clusters, communities, cohesive groups or…

分布式、并行与集群计算 · 计算机科学 2008-06-20 Xiahong Lin , Lin Gao , Kefei Chen , David K. Y. Chiu

We present a novel method for detecting communities in bipartite networks. Based on an extension of the $k$-clique community detection algorithm, we demonstrate how modular structure in bipartite networks presents itself as overlapping…

数据分析、统计与概率 · 物理学 2008-07-22 Sune Lehmann , Martin Schwartz , Lars Kai Hansen

Many complex networks display a mesoscopic structure with groups of nodes sharing many links with the other nodes in their group and comparatively few with nodes of different groups. This feature is known as community structure and encodes…

物理与社会 · 物理学 2009-07-31 Andrea Lancichinetti , Santo Fortunato

Community structure is a typical property of many real-world networks, and has become a key to understand the dynamics of the networked systems. In these networks most nodes apparently lie in a community while there often exists a few nodes…

社会与信息网络 · 计算机科学 2017-12-07 Zhan Weihua , Chen Huahui , Guan Jihong , Jin Guang

Much effort has gone into understanding the modular nature of complex networks. Communities, also known as clusters or modules, are typically considered to be densely interconnected groups of nodes that are only sparsely connected to other…

物理与社会 · 物理学 2012-06-26 James P. Bagrow

Community detection in social graphs has attracted researchers' interest for a long time. With the widespread of social networks on the Internet it has recently become an important research domain. Most contributions focus upon the…

社会与信息网络 · 计算机科学 2014-02-26 Michel Crampes , Michel Plantié

Overlapping communities are key characteristics of the structure and function analysis of complex networks. Shared or overlapping nodes within overlapping communities can form either subcommunities or act as intersections between larger…

社会与信息网络 · 计算机科学 2025-12-19 Vesa Kuikka , Kosti Koistinen , Kimmo K Kaski

Complexes of physically interacting proteins are one of the fundamental functional units responsible for driving key biological mechanisms within the cell. Their identification is therefore necessary not only to understand complex formation…

计算工程、金融与科学 · 计算机科学 2012-11-27 Sriganesh Srihari , Hon Wai Leong

Recent researches have discovered that rich interactions among entities in nature and society bring about complex networks with community structures. Although the investigation of the community structures has promoted the development of…

物理与社会 · 物理学 2008-04-24 Nan Du , Bin Wu , Bai Wang , Yi Wang

This paper presents a new, parallel implementation of clustering and demonstrates its utility in greatly speeding up the process of identifying homologous proteins. Clustering is a technique to reduce the number of comparison needed to find…

分布式、并行与集群计算 · 计算机科学 2019-08-29 Stuart Byma , Akash Dhasade , Adrian Altenhoff , Christophe Dessimoz , James R. Larus

Role discovery is the task of dividing the set of nodes on a graph into classes of structurally similar roles. Modern strategies for role discovery typically rely on graph embedding techniques, which are capable of recognising complex local…

社会与信息网络 · 计算机科学 2022-06-08 Eoghan Cunningham , Derek Greene

Here we present ComPPI, a cellular compartment specific database of proteins and their interactions enabling an extensive, compartmentalized protein-protein interaction network analysis (http://ComPPI.LinkGroup.hu). ComPPI enables the user…

Matrices are two-dimensional data structures allowing one to conceptually organize information. For example, adjacency matrices are useful to store the links of a network; correlation matrices are simple ways to arrange gene co-expression…

无序系统与神经网络 · 物理学 2022-09-29 Flaviano Morone

Complex networks possess a rich, multi-scale structure reflecting the dynamical and functional organization of the systems they model. Often there is a need to analyze multiple networks simultaneously, to model a system by more than one…

物理与社会 · 物理学 2012-11-29 Tom Michoel , Bruno Nachtergaele

Community detection, which focuses on clustering nodes or detecting communities in (mostly) a single network, is a problem of considerable practical interest and has received a great deal of attention in the research community. While being…

机器学习 · 统计学 2017-11-07 Soumendu Sundar Mukherjee , Purnamrita Sarkar , Lizhen Lin

Identification of communities in complex networks has become an effective means to analysis of complex systems. It has broad applications in diverse areas such as social science, engineering, biology and medicine. Finding communities of…

社会与信息网络 · 计算机科学 2013-09-19 Dongxiao He , Di Jin , Weixiong Zhang