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Boolean networks have been proposed as potentially useful models for genetic control. An important aspect of these networks is the stability of their dynamics in response to small perturbations. Previous approaches to stability have assumed…

分子网络 · 定量生物学 2015-05-13 Andrew Pomerance , Edward Ott , Michelle Girvan , Wolfgang Losert

Using Boolean networks as prototypical examples, the role of symmetry in the dynamics of heterogeneous complex systems is explored. We show that symmetry of the dynamics, especially in critical states, is a controlling feature that can be…

统计力学 · 物理学 2015-06-19 Shabnam Hossein , Matthew D. Reichl , Kevin E. Bassler

Boolean networks have been used in a variety of settings, as models for general complex systems as well as models of specific systems in diverse fields, such as biology, engineering, and computer science. Traditionally, their properties as…

Gene regulatory networks (GRNs) play a central role in cellular decision-making. Understanding their structure and how it impacts their dynamics constitutes thus a fundamental biological question. GRNs are frequently modeled as Boolean…

分子网络 · 定量生物学 2024-01-19 Claus Kadelka , Taras-Michael Butrie , Evan Hilton , Jack Kinseth , Addison Schmidt , Haris Serdarevic

We investigated the properties of Boolean networks that follow a given reliable trajectory in state space. A reliable trajectory is defined as a sequence of states which is independent of the order in which the nodes are updated. We…

生物物理 · 物理学 2011-03-23 Tiago P. Peixoto , Barbara Drossel

Boolean networks (BNs) are widely used to model the qualitative dynamics of biological systems. Besides the logical rules determining the evolution of each component with respect to the state of its regulators, the scheduling of component…

计算机科学中的逻辑 · 计算机科学 2019-06-03 Thomas Chatain , Stefan Haar , Juraj Kolčák , Loïc Paulevé , Aalok Thakkar

We study the dynamics of randomly connected networks composed of binary Boolean elements and those composed of binary majority vote elements. We elucidate their differences in both sparsely and densely connected cases. The quickness of…

无序系统与神经网络 · 物理学 2013-03-06 Shun-ichi Amari , Hiroyasu Ando , Taro Toyoizumi , Naoki Masuda

Boolean Networks have been used to study numerous phenomena, including gene regulation, neural networks, social interactions, and biological evolution. Here, we propose a general method for determining the critical behavior of Boolean…

无序系统与神经网络 · 物理学 2009-11-11 Andre A. Moreira , Luis A. N. Amaral

Random networks are a powerful tool in the analytical modeling of complex networks as they allow us to write approximate mathematical models for diverse properties and behaviors of networks. One notable shortcoming of these models is that…

物理与社会 · 物理学 2023-07-10 Laurent Hébert-Dufresne , Márton Pósfai , Antoine Allard

Boolean networks have been widely used in many areas of science and engineering to represent various dynamical behaviour. In systems biology, they became useful tools to study the dynamical characteristics of large-scale biomolecular…

动力系统 · 数学 2024-01-01 Jongrae Kim , Woojeong Lee , Kwang-Hyun Cho

In this paper we try to end the debate concerning the suitability of different updating schemes in random Boolean networks (RBNs). We quantify for the first time loose attractors in asyncrhonous RBNs, which allows us to analyze the…

适应与自组织系统 · 物理学 2011-11-10 Carlos Gershenson

Effective control of biological systems can often be achieved through the control of a surprisingly small number of distinct variables. We bring clarity to such results using the formalism of Boolean dynamical networks, analyzing the…

分子网络 · 定量生物学 2021-09-13 Enrico Borriello , Bryan C. Daniels

Complex networks describe a wide range of systems in nature and society, much quoted examples including the cell, a network of chemicals linked by chemical reactions, or the Internet, a network of routers and computers connected by physical…

统计力学 · 物理学 2016-08-31 Reka Albert , Albert-Laszlo Barabasi

Boolean networks can be viewed as functions on the set of binary strings of a given length, described via logical rules. They were introduced as dynamic models into biology, in particular as logical models of intracellular regulatory…

Complex systems are often modeled as Boolean networks in attempts to capture their logical structure and reveal its dynamical consequences. Approximating the dynamics of continuous variables by discrete values and Boolean logic gates may,…

分子网络 · 定量生物学 2013-05-29 Johannes Norrell , Joshua E. S. Socolar

This paper reviews a class of generic dissipative dynamical systems called N-K models. In these models, the dynamics of N elements, defined as Boolean variables, develop step by step, clocked by a discrete time variable. Each of the N…

适应与自组织系统 · 物理学 2007-05-23 Leo Kadanoff , Susan Coppersmith , Maximino Aldana

The determination and classification of fixed points of large Boolean networks is addressed in terms of constraint satisfaction problem. We develop a general simplification scheme that, removing all those variables and functions belonging…

无序系统与神经网络 · 物理学 2009-11-10 L. Correale , M. Leone , A. Pagnani , M. Weigt , R. Zecchina

Identifying dynamically influential nodes in biological networks is a central problem in systems biology, particularly for prioritizing intervention targets in gene regulatory networks. In this paper, we propose a Shapley-value-based…

分子网络 · 定量生物学 2026-04-13 Giang Pham , Silvia Giulia Galfrè , Paolo Milazzo

We consider a model for heterogeneous 'gene regulatory networks' that is a generalization of the model proposed by Chatterjee and Durrett (2011) as an "annealed approximation" of Kauffmann's (1969) random Boolean networks. In this model,…

概率论 · 数学 2013-10-17 Shirshendu Chatterjee

A Boolean network (BN) with $n$ components is a discrete dynamical system described by the successive iterations of a function $f:\{0,1\}^n \to \{0,1\}^n$. This model finds applications in biology, where fixed points play a central role.…

组合数学 · 数学 2022-02-10 Florian Bridoux , Amélia Durbec , Kévin Perrot , Adrien Richard