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We find a statistical mechanism that can adjust orientations of intracellular filaments to cell geometry in absence of organizing centers. The effect is based on random and isotropic filament (de-)polymerization dynamics and is independent…

生物物理 · 物理学 2015-05-28 Philip Greulich , Ludger Santen

The collective dynamics of $N$ weakly coupled processive molecular motors are considered theoretically. We show, using a discrete lattice model, that the velocity-force curves strongly depend on the effective dynamic interactions between…

亚细胞过程 · 定量生物学 2009-11-11 O. Campas , Y. Kafri , K. B. Zeldovich , J. Casademunt , J. -F. Joanny

Trying to enumerate all of the walks in a 2D lattice is a fun combinatorial problem and there are numerous applications, from polymers to sports. Computers provide a wonderful tool for analyzing these walks; we provide a Maple package for…

组合数学 · 数学 2018-04-18 Bryan Ek

Intracellular transport processes driven by molecular motors can be described by stochastic lattice models of self-driven particles. Here we focus on bidirectional transport models excluding the exchange of particles on the same track. We…

生物物理 · 物理学 2015-05-27 M. Ebbinghaus , C. Appert-Rolland , L. Santen

We investigate the dynamics of several slender rigid bodies moving in a flow driven by the three-dimensional steady Stokes system in presence of a smooth background flow. More precisely we consider the limit where the thickness of these…

偏微分方程分析 · 数学 2024-12-31 Richard M. Höfer , Christophe Prange , Franck Sueur

Within the framework of variational modelling we derive a one-phase moving boundary problem describing the motion of a semipermeable membrane enclosing a viscous liquid, driven by osmotic pressure and surface tension of the membrane. For…

偏微分方程分析 · 数学 2019-02-20 Friedrich Lippoth , Mark A. Peletier , Georg Prokert

We consider a generalization of a one-dimensional stochastic process known in the physical literature as L\'evy-Lorentz gas. The process describes the motion of a particle on the real line in the presence of a random array of marked points,…

Motor-driven cytoskeletal remodeling in cellular systems can often be accompanied by a diffusive-like effect at local scales, but distinguishing the contributions of the ordering process, such as active contraction of a network, from this…

Reconstituted filamentous actin networks with myosin motor proteins form active gels, in which motor proteins generate forces that drive the network far from equilibrium. This motor activity can also strongly affect the network elasticity;…

软凝聚态物质 · 物理学 2010-09-21 C. P. Broedersz , F. C. MacKintosh

We discuss a two-dimensional model for the dynamics of axonemal deformations driven by internally generated forces of molecular motors. Our model consists of an elastic filament pair connected by active elements. We derive the dynamic…

生物物理 · 物理学 2009-11-06 Sebastien Camalet , Frank Julicher

Many cellular processes rely on the cell's ability to transport material to and from the nucleus. Networks consisting of many microtubules and actin filaments are key to this transport. Recently, the inhibition of intracellular transport…

亚细胞过程 · 定量生物学 2020-05-06 Shawn D. Ryan , Zachary McCarthy , Mykhailo Potomkin

Motor-proteins are responsible for transport inside cells. Harnessing their activity is key towards developing new nano-technologies, or functional biomaterials. Cytoskeleton-like networks, recently tailored in vitro, result from the…

软凝聚态物质 · 物理学 2016-06-21 Pau Guillamat , Jordi Ignés-Mullol , Francesc Sagués

Generation of mechanical oscillation is ubiquitous to wide variety of intracellular processes. We show that catchbonding behaviour of motor proteins provides a generic mechanism of generating spontaneous oscillations in motor-cytoskeletal…

亚细胞过程 · 定量生物学 2021-11-11 Sougata Guha , MIthun K. Mitra , Ignacio Pagonabarraga , Sudipto Muhuri

Dynamics of molecular motor dimers, consisting of rigidly bound particles that move along two parallel lattices and interact with underlying molecular tracks, is investigated theoretically by analyzing discrete-state stochastic…

统计力学 · 物理学 2009-11-13 Alexander Yu. Morozov , Anatoly B. Kolomeisky

The forces that mixtures of motorized and passive crosslinking proteins collectively generate between cytoskeletal filaments within our cells are the key drivers of active cellular mechanics. Despite their importance, a unified theory to…

软凝聚态物质 · 物理学 2026-02-23 Cedrik Barutel , Sebastian Fürthauer

Sums of walks for charged particles (e.g. Hofstadter electrons) on a square lattice in the presence of a magnetic field are evaluated. Returning loops are systematically added to directed paths to obtain the unrestricted propagators.…

凝聚态物理 · 物理学 2009-10-22 Thomas Blum , Yonathan Shapir

In eukaryotic cells, motor proteins (MP) bind to cytoskeletal filaments and move along them in a directed manner generating active stresses. During cell division a spindle structure of overlapping antiparallel microtubules (MT) form whose…

Active matter consists of self-propelled elements exhibits fascinating collective motions ranging from biological to artificial systems. Among wide varieties of active matter systems, reconstituted bio-filaments moving on molecular motor…

We consider a discrete-time random walk on the nodes of an unbounded hexagonal lattice. We determine the probability generating functions, the transition probabilities and the relevant moments. The convergence of the stochastic process to a…

概率论 · 数学 2019-09-16 Antonio Di Crescenzo , Claudio Macci , Barbara Martinucci , Serena Spina

We use colloidal suspensions encapsulated in emulsion droplets to model confined glass-forming liquids with tunable boundary mobility. We show dynamics in these idealized systems are governed by physical interactions with the boundary.…

软凝聚态物质 · 物理学 2014-05-29 Gary L. Hunter , Kazem V. Edmond , Eric R. Weeks