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We evaluate the efficiency of various heuristic strategies for allocating vaccines against COVID-19 and compare them to strategies found using optimal control theory. Our approach is based on a mathematical model which tracks the spread of…

We present a series of SIR-network models, extended with a game-theoretic treatment of imitation dynamics which result from regular population mobility across residential and work areas and the ensuing interactions. Each considered…

种群与进化 · 定量生物学 2019-11-14 Sheryl L. Chang , Mahendra Piraveenan , Mikhail Prokopenko

As observed during the COVID-19 pandemic, high-income countries, such as the U.S., may exhibit vaccine nationalism during a pandemic: stockpiling doses of vaccine for their own citizens and being reluctant to distribute doses of the vaccine…

种群与进化 · 定量生物学 2024-08-21 Abraham Holleran , Susan E. Martonosi , Michael Veatch

Motivated by the issue of COVID-19 mitigation, in this work we tackle the general problem of optimally controlling an epidemic outbreak of a communicable disease structured by time since exposure, by the aid of two types of control…

种群与进化 · 定量生物学 2024-05-13 Alberto d'Onofrio , Mimmo Iannelli , Piero Manfredi , Gabriela Marinoschi

Massive vaccination against pandemics such as Coronavirus SARS-CoV-2 presents several complexities. The criteria to assess public health policies are fundamental to distribute vaccines in an effective way in order to avoid as many…

最优化与控制 · 数学 2023-12-01 José Luis Sainz-Pardo , José Valero

In this paper we investigate the asymptotic behavior of some SIR models incorporating demography, bounded random transmission coefficient and a time-dependent vaccination strategy targeting the susceptible population. In this setting, we…

种群与进化 · 定量生物学 2025-10-27 Javier López-de-la-Cruz , Susana Merchán , Felipe Rivero , Javier Rodrigo

This work focuses on optimal controls of a class of stochastic SIS epidemic models under regime switching. By assuming that a decision maker can either influence the infectivity period or isolate infected individuals, our aim is to minimize…

最优化与控制 · 数学 2021-01-12 Ky Tran , George Yin

How to prevent the spread of human diseases is a great challenge for the scientific community and so far there are many studies in which immunization strategies have been developed. However, these kind of strategies usually do not consider…

物理与社会 · 物理学 2018-08-22 M. A. Di Muro , L. G. Alvarez-Zuzek , S. Havlin , L. A. Braunstein

In this paper, we consider an optimal distributed control problem for a reaction-diffusion-based SIR epidemic model with human behavioral effects. We develop a model wherein non-pharmaceutical intervention methods are implemented, but a…

偏微分方程分析 · 数学 2025-02-11 Marcelo Bongarti , Christian Parkinson , Weinan Wang

The optimal allocation of vaccines to population subgroups over time is a challenging health care management problem. In the context of a pandemic, the interaction between vaccination policies adopted by multiple agents and the cooperation…

最优化与控制 · 数学 2021-09-22 David Rey , Ahmed W Hammad , Meead Saberi

In this research paper we modify a classical SIR model to better adapt to the dynamics of COVID-19, that is we propose the heterogeneous SQAIRD model where COVID-19 spreads over a population of economic agents, namely: the elderly, adults…

最优化与控制 · 数学 2021-05-19 Elena Gubar , Laura Policardo , Edgar J. Sanchez Carrera , Vladislav Taynitskiy

To understand the impact of vaccination, we consider a SIVR (susceptible-infected-vaccinated-recovered) model which combines impulsive vaccination into the classical SIR model. The final size is firstly defined and estimated, and then the…

种群与进化 · 定量生物学 2024-10-29 Phyu Phyu Win , Zhigui Lin , Mengyun Zhang

Non-pharmacological interventions (NPIs), and in particular social distancing, in conjunction with the advent of effective vaccines at the end of 2020, aspired for the development of a protective immunity shield against the spread of…

We study the problem of optimal control of the stochastic SIR model. Models of this type are used in mathematical epidemiology to capture the time evolution of highly infectious diseases such as COVID-19. Our approach relies on…

种群与进化 · 定量生物学 2020-05-04 Andrew Lesniewski

We propose a versatile model with a flexible choice of control for an early-pandemic outbreak prevention when vaccine/drug is not yet available. At that stage, control is often limited to non-medical interventions like social distancing and…

最优化与控制 · 数学 2024-06-14 Alexandra Smirnova , Xiaojing Ye

This paper deals with an SIR model with saturated incidence rate affected by inhibitory effect and saturated treatment function. Two control functions have been used, one for vaccinating the susceptible population and other for the…

动力系统 · 数学 2018-07-17 Jayanta Kumar Ghosh , Uttam Ghosh , M. H. A. Biswas , Susmita Sarkar

In this research, we develop a framework to analyze the interaction between the economy and the Covid-19 pandemic using an extension of SIR epidemic model. At the outset, we assume there are two health related investments including general…

最优化与控制 · 数学 2022-02-14 Zachariah Sinkala , Vajira Manathunga , Bichaka Fayissa

Understanding the epidemic dynamics, and finding out efficient techniques to control it, is a challenging issue. A lot of research has been done on targeted immunization strategies, exploiting various global network topological properties.…

社会与信息网络 · 计算机科学 2016-01-21 Naveen Gupta , Anurag Singh , Hocine Cherifi

We present a SIR+ASI epidemic model to describe the interaction between human and dengue fever mosquito populations. A control strategy in the form of vaccination, to decrease the number of infected individuals, is used. An optimal control…

最优化与控制 · 数学 2011-09-19 Helena Sofia Rodrigues , M. Teresa T. Monteiro , Delfim F. M. Torres

In this work, we investigate a VS-EIAR epidemiological model that incorporates vaccinated individuals $\{V_i : i = 1, \ldots, n\}$, where $n \in \mathbb{N}^{*}$. The dynamics of the VS-EIAR model are governed by a system of ordinary…

动力系统 · 数学 2025-07-16 Mamadou Abdoul Diop , Mohammed Elghandouri , Khalil Ezzinbi