相关论文: Divergence of detachment forces in the finite Voro…
Voronoi tessellations have been used to model the geometric arrangement of cells in morphogenetic or cancerous tissues, however so far only with flat hypersurfaces as cell-cell contact borders. In order to reproduce the experimentally…
Navigating topological transitions in cellular mechanical systems is a significant challenge for existing simulation methods. While abstract models lack predictive capabilities at the cellular level, explicit network representations…
In this paper, the Discontinuous Cell Method (DCM) is formulated with the objective of simulating cohesive fracture propagation and fragmentation in homogeneous solids without issues relevant to excessive mesh deformation typical of…
The Voronoi-based cellular model is highly successful in describing the motion of two-dimensional confluent cell tissues. In the homogeneous version of this model, the energy of each cell is determined solely by its geometric shape and…
An important open question in the modeling of biological tissues is how to identify the right scale for coarse-graining, or equivalently, the right number of degrees of freedom. For confluent biological tissues, both vertex and Voronoi…
We consider problem of constructing purely Voronoi mesh where the union of uncut Voronoi cells approximates the planar computational domain with piecewise-smooth boundary. Smooth boundary fragments are approximated by the Voronoi edges and…
The dynamics of glassy materials slows down upon cooling, typically showing either Arrhenius or super-Arrhenius behavior. However, it was recently shown that 2D cell-based models for biological tissues can be continuously tuned between…
We study the problem of decomposing a volume bounded by a smooth surface into a collection of Voronoi cells. Unlike the dual problem of conforming Delaunay meshing, a principled solution to this problem for generic smooth surfaces remained…
Unlike other schemes that locally violate the essential stability properties of the analytic parabolic and elliptic problems, Voronoi finite volume methods (FVM) and boundary conforming Delaunay meshes provide good approximation of the…
Voronoi diagrams appear in many areas in science and technology and have numerous applications. They have been the subject of extensive investigation during the last decades. Roughly speaking, they are a certain decomposition of a given…
Computational technologies for the approximate solution of multidimensional boundary value problems often rely on irregular computational meshes and finite-volume approximations. In this framework, the discrete problem represents the…
Tuning cell rearrangements is essential in collective cell movement that underlies cancer progression, wound repair, and embryonic development. A key question is how tissue material properties and morphology emerge from cellular factors…
We use a simple fragmentation model to describe the statistical behavior of the Voronoi cell patterns generated by a set of points in 1D and in 2D. In particular, we are interested in the distribution of sizes of these Voronoi cells. Our…
Vertex models are a popular approach to modeling the mechanical and dynamical properties of dense biological tissues, describing the tissue as a network of connected polygons representing the cells. Recently a class of two-dimensional…
Real complex networks are often characterized by spatial constraints such as the relative position and adjacency of nodes. The present work describes how Voronoi tessellations of the space where the network is embedded provide not only a…
Many methods for modelling spatial processes assume global smoothness properties; such assumptions are often violated in practice. We introduce a method for modelling spatial processes that display heterogeneity or contain discontinuities.…
The Voronoi model is a popular tool for studying confluent living tissues. It exhibits an anomalous glassy behavior even at very low temperatures or weak active self-propulsion, and at zero temperature the model exhibits a disordered solid…
We consider the Voronoi diagram generated by $n$ i.i.d. $\mathbb{R}^{d}$-valued random variables with an arbitrary underlying probability density function $f$ on $\mathbb{R}^{d}$, and analyse the asymptotic behaviours of certain geometric…
Epithelia are confluent cell layers that self-organize into polygonal networks whose geometry encodes their mechanical state. A principal driver is the tunable contractility of the actomyosin cortex, which links cell-junction tension to…
Multicellular rosettes are observed in different situations such as morphogenesis, wound healing, and cancer progression. While some molecular insights have been gained to explain the presence of these assemblies of five or more cells…