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Biological cells embedded in fibrous matrices have been observed to form inter-cellular bands of dense and aligned fibers, through which they mechanically interact over long distances. Such matrix-mediated cellular interactions have been…

Shearing stresses can change the volume of a material via a nonlinear effect known as shear dilatancy. We calculate the elastic dilatancy coefficient of soft sphere packings and random spring networks, two canonical models of marginal…

软凝聚态物质 · 物理学 2016-07-06 Brian P. Tighe

During development and under normal physiological conditions, biological tissues are continuously subjected to substantial mechanical stresses. In response to large deformations cells in a tissue must undergo multicellular rearrangements in…

生物物理 · 物理学 2025-04-08 Anh Q. Nguyen , Junxiang Huang , Dapeng Bi

This paper introduces Stress-Aware Learning, a resilient neural training paradigm in which deep neural networks dynamically adjust their optimization behavior - whether under stable training regimes or in settings with uncertain dynamics -…

机器学习 · 计算机科学 2025-08-04 Ashkan Shakarami , Yousef Yeganeh , Azade Farshad , Lorenzo Nicole , Stefano Ghidoni , Nassir Navab

Collagen forms the structural scaffold of connective tissues in all mammals. Tissues are remarkably resistant against mechanical deformations because collagen molecules hierarchically self-assemble in fibrous networks that stiffen with…

We explore the concept of memory in scalar active matter, focusing on the collective dynamics of particles whose interactions depend on their evolutionary history rather than solely on their current configuration. We introduce the idea of…

软凝聚态物质 · 物理学 2026-03-25 Vaishnavi Gajendragad , Suropriya Saha

Collagen fibrils are the building block of many biological tissues, which viability depend on the fibrils properties. Altered properties of collagen fibrils are central to the appearance of many diseases, while physiological or native…

软凝聚态物质 · 物理学 2026-05-08 Konstantinos Steiakakis , Alan Pichard , Maxime Vassaux

We explore the link between soft vibrational modes and local relaxation events in polymer glasses during physical aging, active deformation at constant strain rate, and subsequent recovery. A softness field is constructed out of the…

软凝聚态物质 · 物理学 2015-11-18 Anton Smessaert , Joerg Rottler

The aim of this work is to develop a neural network for modelling incompressible hyperelastic behaviour with isotropic damage, the so-called Mullins effect. This is obtained through the use of feed-forward neural networks with special…

计算物理 · 物理学 2024-11-21 Martin Zlatić , Marko Čanađija

A growing body of research indicates that structural plasticity mechanisms are crucial for learning and memory consolidation. Starting from a simple phenomenological model, we exploit a mean-field approach to develop a theoretical framework…

神经元与认知 · 定量生物学 2024-06-19 Gianmarco Tiddia , Luca Sergi , Bruno Golosio

Memory-forming properties introduce a new paradigm to the design of adaptive materials. In dense suspensions, an adaptive response is enabled by non-Newtonian rheology; however, typical suspensions have little memory, which implies rapid…

软凝聚态物质 · 物理学 2025-03-13 Hojin Kim , Samantha M. Livermore , Stuart J. Rowan , Heinrich M. Jaeger

Photoelastic techniques have a long tradition in both qualitative and quantitative analysis of the stresses in granular materials. Over the last two decades, computational methods for reconstructing forces between particles from their…

计算机视觉与模式识别 · 计算机科学 2021-08-04 Renat Sergazinov , Miroslav Kramar

Tuning of active prestress e.g. through activity of molecular motors constitutes a powerful cellular tool to adjust cellular stiffness through nonlinear material properties. Understanding this tool is an important prerequisite for our…

软凝聚态物质 · 物理学 2018-08-24 Elisabeth Fischer-Friedrich

Stochastic network-dynamics are typically assumed to be memory-less. Involving prolonged dwells interrupted by instantaneous transitions between nodes such Markov networks stand as a coarse-graining paradigm for chemical reactions, gene…

统计力学 · 物理学 2021-12-15 David Hartich , Aljaž Godec

The predominant structural protein in vertebrates is collagen, which plays a key role in extracellular matrix and connective tissue mechanics. Despite its prevalence and physical importance in biology, the mechanical properties of molecular…

生物物理 · 物理学 2018-11-14 Naghmeh Rezaei , Aaron Lyons , Nancy R. Forde

During the last decade, network approaches became a powerful tool to describe protein structure and dynamics. Here, we describe first the protein structure networks of molecular chaperones, then characterize chaperone containing…

分子网络 · 定量生物学 2014-04-28 David M. Gyurko , Csaba Soti , Attila Stetak , Peter Csermely

Memory systems can store vastly different amounts of information despite similar hardware constraints. Here, we show that superior spatial memory emerges from a discrete stiffening of hippocampal population geometry-a transition from…

神经元与认知 · 定量生物学 2026-05-19 Prashant C. Raju

Slow dynamics in disordered materials prohibits direct simulation of their rich nonequilibrium behavior at large scales. "Patchwork dynamics" is introduced to mimic relaxation over a very broad range of time scales by equilibrating or…

无序系统与神经网络 · 物理学 2009-06-30 Creighton K. Thomas , Olivia L. White , A. Alan Middleton

The rheological properties of fibrin networks have been of long-standing interest. As such there is a wealth of studies of their shear and tensile responses, but their compressive behavior remains unexplored. Here, by characterization of…

软凝聚态物质 · 物理学 2015-08-27 O. V. Kim , Xiaojun Liang , Rustem I. Litvinov , John W. Weisel , Mark S. Alber , Prashant K. Purohit

We study conductivity of strongly disordered amorphous antimony films under high bias voltages. We observe non-linear current-voltage characteristic, where the conductivity value at zero bias is one of two distinct values, being determined…

介观与纳米尺度物理 · 物理学 2020-05-11 N. N. Orlova , S. I. Bozhko , E. V. Deviatov